Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Tongli Zhang"'
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Introduction: This study explores using Neural Ordinary Differential Equations (NODEs) to analyze hormone dynamics in the hypothalamicpituitary-adrenal (HPA) axis during Trier Social Stress Tests (TSST) to classify patients with Major Depressive Diso
Externí odkaz:
https://doaj.org/article/64a6b24490a74437bed24834e27d6556
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 6, Pp 669-672 (2022)
Externí odkaz:
https://doaj.org/article/cef587722d9649b09e4afcd5c1361126
Autor:
Tongli Zhang
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Heterogeneity among individual patients presents a fundamental challenge to effective treatment, since a treatment protocol working for a portion of the population often fails in others. We hypothesize that a computational pipeline integrating mathem
Externí odkaz:
https://doaj.org/article/ae7df39bc3b44934b09e93ea598c569f
Publikováno v:
Entropy, Vol 24, Iss 12, p 1747 (2022)
In order for mathematical models to make credible contributions, it is essential for them to be verified and validated. Currently, verification and validation (V&V) of these models does not meet the expectations of the system biology and systems phar
Externí odkaz:
https://doaj.org/article/29231794f9104484bfca32516df5782f
Autor:
Tomoyuki U. Tanaka, Tongli Zhang
Publikováno v:
Cells, Vol 11, Iss 9, p 1462 (2022)
For correct chromosome segregation in mitosis, eukaryotic cells must establish chromosome biorientation where sister kinetochores attach to microtubules extending from opposite spindle poles. To establish biorientation, any aberrant kinetochore–mic
Externí odkaz:
https://doaj.org/article/a3cc65d27e6441b69899f1c65819dd17
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Biological processes are dynamic. As a result, temporal analyses are necessary to fully understand the complex interactions that occurs within these systems. One example of a multifaceted biological process is restitution: the initial step in complex
Externí odkaz:
https://doaj.org/article/2558dad24a2147ceaa65a4acf0253778
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract When chemotherapy drugs are applied to tumor cells with the same or similar genotypes, some cells are killed, while others survive. This fractional killing contributes to drug resistance in cancer. Through an incoherent feedforward loop, che
Externí odkaz:
https://doaj.org/article/ae89e0aee4dd4bcc96569fe1115175e6
Publikováno v:
Journal of Inequalities and Applications, Vol 2017, Iss 1, Pp 1-16 (2017)
Abstract This article presents a new approximation algorithm for globally solving a class of generalized fractional programming problems (P) whose objective functions are defined as an appropriate composition of ratios of affine functions. To solve t
Externí odkaz:
https://doaj.org/article/bba78971fca042649d2a740e6a01fe14
Autor:
Yin Zhang, Julie M Huynh, Guan-Sheng Liu, Richard Ballweg, Kayenat S Aryeh, Andrew L Paek, Tongli Zhang
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 9, p e1007158 (2019)
Chemotherapy resistance is a major challenge to the effective treatment of cancer. Thus, a systematic pipeline for the efficient identification of effective combination treatments could bring huge biomedical benefit. In order to facilitate rational d
Externí odkaz:
https://doaj.org/article/f501b1749c324b698edad8e4e09907c9
Autor:
Julia E Sero, Heba Zuhair Sailem, Rico Chandra Ardy, Hannah Almuttaqi, Tongli Zhang, Chris Bakal
Publikováno v:
Molecular Systems Biology, Vol 11, Iss 3, Pp 1-16 (2015)
Abstract Although a great deal is known about the signaling events that promote nuclear translocation of NF‐κB, how cellular biophysics and the microenvironment might regulate the dynamics of this pathway is poorly understood. In this study, we us
Externí odkaz:
https://doaj.org/article/9e159c8842f1468e860ed1768eef723e