Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Tongju Guan"'
Autor:
Urikhan Sanzhaeva, Helen Boyd-Pratt, Philip T. R. Bender, Thamaraiselvi Saravanan, Scott B. Rhodes, Tongju Guan, Neil Billington, Shannon E. Boye, Christopher L. Cunningham, Charles T. Anderson, Visvanathan Ramamurthy
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-18 (2024)
Abstract Microtubules are essential for various cellular processes. The functional diversity of microtubules is attributed to the incorporation of various α- and β-tubulin isotypes encoded by different genes. In this work, we investigated the funct
Externí odkaz:
https://doaj.org/article/2bce1a002054404696b0451fc39c920b
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Prominin 1 (PROM1) is a pentaspan transmembrane glycoprotein localized on the nascent photoreceptor discs. Mutations in PROM1 are linked to various retinal diseases. In this study, we assessed the role of PROM1 in photoreceptor biology and p
Externí odkaz:
https://doaj.org/article/8279a39f068b49c4bea5da400431c024
Autor:
Hao Zhang, Xigang Jing, Yang Shi, Hao Xu, Jianhai Du, Tongju Guan, Dorothee Weihrauch, Deron W. Jones, Weiling Wang, David Gourlay, Keith T. Oldham, Cheryl A. Hillery, Kirkwood A. Pritchard, Jr.
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 11, Pp 3016-3029 (2013)
Myeloperoxidase (MPO) plays important roles in disease by increasing oxidative and nitrosative stress and oxidizing lipoproteins. Here we report N-acetyl lysyltyrosylcysteine amide (KYC) is an effective inhibitor of MPO activity. We show KYC inhibits
Externí odkaz:
https://doaj.org/article/ea916cdff05b4e8b905ac1c011947594
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33991 (2012)
GTP cyclohydrolase I (GCH1) is the rate-limiting enzyme for tetrahydrobiopterin biosynthesis and has been shown to be a promising therapeutic target in ischemic heart disease, hypertension, atherosclerosis and diabetes. The endogenous GCH1-interactin
Externí odkaz:
https://doaj.org/article/4214e65414884f09aaeca691ec243b83
Autor:
Daniella Munezero, Hunter Aliff, Ezequiel Salido, Thamaraiselvi Saravanan, Urikhan Sanzhaeva, Tongju Guan, Visvanathan Ramamurthy
Publikováno v:
Journal of Biological Chemistry. :104809
Autor:
Elizabeth Gregor, Quan Shi, Andrew F.X. Goldberg, Jianhai Du, Nancy J. Philp, James B. Hurley, Daniel Lohner, Joseph Murphy, Michelle Yam, Yekai Wang, Jonathan D. Linton, Allison Hauer, Allison Grenell, Siyan Zhu, Aditi Swarup, Tongju Guan, Visvanathan Ramamurthy, Saravanan Kolandaivelu, Tanya L. Dilan
Glucose metabolism in vertebrate retinas is dominated by aerobic glycolysis (the “Warburg Effect”), which allows only a small fraction of glucose-derived pyruvate to enter mitochondria. Here, we report evidence that the small fraction of pyruvate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a07d891e72a6b41f45c4d531c1897e
https://europepmc.org/articles/PMC6397593/
https://europepmc.org/articles/PMC6397593/
Autor:
Xigang Jing, David M. Gourlay, Yang Shi, Weiling Wang, Deron W. Jones, Kirkwood A. Pritchard, Dorothee Weihrauch, Hao Zhang, Tongju Guan, Cheryl A. Hillery, Jianhai Du, Keith T. Oldham, Hao Xu
Publikováno v:
Journal of Lipid Research. 54:3016-3029
Myeloperoxidase (MPO) plays important roles in disease by increasing oxidative and nitrosative stress and oxidizing lipoproteins. Here we report N-acetyl lysyltyrosylcysteine amide (KYC) is an effective inhibitor of MPO activity. We show KYC inhibits
Autor:
Scott R. Welak, Annie Eis, Tongju Guan, Ru-Jeng Teng, Girija G. Konduri, Jianhai Du, Yang Shi
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 302:L651-L663
Autophagy is a process for cells to degrade proteins or entire organelles to maintain a balance in the synthesis, degradation, and subsequent recycling of cellular products. Increased reactive oxygen species formation is known to induce autophagy. We
Publikováno v:
Shock. 37:325-332
Recently, we reported that Brown Norway (BN) rats were more resistant to lipopolysaccharide (LPS)-induced myocardial dysfunction than Dahl S (SS) rats. This differential sensitivity was exemplified by reduced production of proinflammatory cytokines a
Publikováno v:
American Journal of Physiology-Cell Physiology. 302:C383-C391
Angiogenesis plays critical roles in the recovery phase of ischemic heart disease and peripheral vascular disease. An increase in autophagy is protective under hypoxic and chronic ischemic conditions. In the present study we determined the role of au