Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Tong-Lan Ngiam"'
Publikováno v:
European Journal of Pharmaceutical Sciences. 6:19-26
The synthesis, physicochemical characterization and in vitro antimalarial activity of a series of indolo[3,2-c]quinolines (9a-f) are described. There is only a poor correlation between the activity and hydrophobicity. In contrast, 33% of the observed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e763f26178297f6137890844269a055a
https://doi.org/10.1016/s0928-0987(97)00064-x
https://doi.org/10.1016/s0928-0987(97)00064-x
Autor:
Mei-Lin Go, Tong Lan Ngiam
Publikováno v:
Chemical and Pharmaceutical Bulletin. 45:2055-2060
The antimalarial drug mefloquine binds avidly to phospholipids in biomembranes. The thermodynamics of the partitioning process in dimyristoylphosphatidylcholine (DMPC) bilayers was investigated to give some insight into the drug-phospholipid interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8449874a8f81197cff0c5d2282535b70
https://doi.org/10.1248/cpb.45.2055
https://doi.org/10.1248/cpb.45.2055
Publikováno v:
Chemical and Pharmaceutical Bulletin. 43:289-294
The thermodynamics of the partitioning of 7-chloro-4-(4'-methoxy)anilinoquinoline (I) and its cyclized analogue, 3-chloro-8-methoxy-11H-indolo[3, 2-c]quinoline (II) have been determined in octanol-buffer and liposome systems.Under the conditions of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c17f21ad681843b7454c893fa579143
https://doi.org/10.1248/cpb.43.289
https://doi.org/10.1248/cpb.43.289
Autor:
M. J. O'Neill, D. C. Warhurst, G. C. Kirby, H. L. Koh, Tong Lan Ngiam, M. L. Go, J. D. Phillipson
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9bbec0c760db120d1f822a291804587
https://doi.org/10.1002/chin.199244210
https://doi.org/10.1002/chin.199244210
Publikováno v:
European Journal of Medicinal Chemistry. 27:391-394
A series of indolo[3,2-c]quinolines (1b–e) was synthesized by Fischer indolization of 7-chloro-1,2,3,4-tetrahydroquinolin-4-one with the appropriate hydrazines (7b–e). Evaluation of in vitro antimalarial activity was carried out against a chloroq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ccbc185c357b42bf6928ece3d8200d8
https://doi.org/10.1016/0223-5234(92)90152-q
https://doi.org/10.1016/0223-5234(92)90152-q
Publikováno v:
Steroids. 56:30-32
Alternative methods that can be used to synthesize certain key intermediary compounds in the preparation of 1 alpha-hydroxylated vitamin D have been described. These methods are simple and give higher yields than the reported procedures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8afb74e5c99a3ed8aa2f6101f3657c9
https://doi.org/10.1016/0039-128x(91)90111-8
https://doi.org/10.1016/0039-128x(91)90111-8
Publikováno v:
Chemicalpharmaceutical bulletin. 42(5)
The molecular geometry, acid dissociation constants and partition coefficients of the anilinoquinoline (I), indolo[3,2-c]quinoline (II) and tetrahydroindolo[3,2-d] [1]benzazepine (III) ring systems have been determined using representative compounds:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3baec64d21e1fa7db390fa35ac6f5de6
https://pubmed.ncbi.nlm.nih.gov/8069960
https://pubmed.ncbi.nlm.nih.gov/8069960
Publikováno v:
Biologicalpharmaceutical bulletin. 16(7)
The effects of the antimalarial agent, (+/-)-erythro-mefloquine and related compounds [(+/-)-threo-mefloquine, (+/-)-erythro-N-methylmefloquine and its N-oxide, quinine, WR 184806 and halofanthrine] on the isolated mouse phrenic nerve diaphragm prepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8333aa8a7b7f0365bf43877c28226673
https://pubmed.ncbi.nlm.nih.gov/8401399
https://pubmed.ncbi.nlm.nih.gov/8401399
Autor:
Mei-Lin Go, Tong Lan Ngiam
Publikováno v:
Chemical and Pharmaceutical Bulletin. 36:1393-1398
The change in hydrophobicity on N-oxidation of the ring nitrogen of quinoline and its 4-amino derivatives was determined by the shake-flask method and reverse phase liquid chromatography (RPLC), buffered at an appropriate pH. Hydrophobicity was expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a257e2270e688b83a3bc0126b0da110f
https://doi.org/10.1248/cpb.36.1393
https://doi.org/10.1248/cpb.36.1393
Autor:
Mei Lin Go, Tong Lan Ngiam
Publikováno v:
Chemical and Pharmaceutical Bulletin. 35:409-412
Mefloquine enantiomers (+) -1, (-) -1 were found to be stereospecific in their inhibition of acetylcholinesterase and butyrylcholinesterase, (-) -1 being the more potent inhibitor in both cases. Similar observations were also made with respect to (-)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858b798d7002672c74b597aadbb5d388
https://doi.org/10.1248/cpb.35.409
https://doi.org/10.1248/cpb.35.409