Výsledky vyhledávání - "Tong Tong, Zou"

Regulation of adherens junctions and epithelial paracellular permeability: a novel function for polyamines

Autor: Douglas J. Turner, Xin Guo, Lan Liu, Jian Ying Wang, Barbara L. Bass, Tong Tong Zou, Jaladanki N. Rao

Publikováno v: American Journal of Physiology-Cell Physiology. 285:C1174-C1187

Maintenance of intestinal mucosal epithelial integrity requires polyamines that are involved in the multiple signaling pathways controlling gene expression and different epithelial cell functions. Integrity of the intestinal epithelial barrier depend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6282cb6e1bcd26d78ec57f84a106f9d
https://doi.org/10.1152/ajpcell.00015.2003

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Mutation of hMSH3 and hMSH6 mismatch repair genes in genetically unstable human colorectal and gastric carcinomas

Autor: Stanley R. Hamilton, Joanne P. Young, Dehe Kong, Haruhiko Sugimura, Suna Wang, Tong Tong Zou, John M. Abraham, Jing Yin, Steven M. Powell, Kara N. Smolinski, Rhonda F. Souza, Patrick M. Lynch, Stephen J. Meltzer

Publikováno v: Human Mutation. 10:474-478

Mutations within microsatellite sequences, consisting of additions or deletions of repeat units, are known as the replication/repair error positive (RER+) phenotype or micorsatellite instability (MI). Microsatellite instability has been demonstrated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27df46ef6562f6e2c1dfa7515cc5143a
https://doi.org/10.1002/(sici)1098-1004(1997)10:6<474::aid-humu9>3.3.co

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An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma

Autor: Fumiaki Sato, Menghong Sun, Martha Kimos, Tong Tong Zou, Elena Deacu, John M. Abraham, Jing Yin, Yan Xu, David Shibata, Bruce D. Greenwald, Kellie Perry, Suna Wang, Ying Chang Shi, Andreea Olaru, Stephen J. Meltzer, Yuriko Mori, Florin M. Selaru

Publikováno v: Oncogene. 22(3)

Frequent loss of heterozygosity (LOH) on human chromosome 7q31 has been reported in numerous malignancies. Suppressor of tumorigenicity 7 (ST7) has been identified as a candidate tumor suppressor gene in this region. To identify whether 7q31 and gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d74a6fcc7fd1f76c26558dee656e87
https://pubmed.ncbi.nlm.nih.gov/12545169

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Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers

Autor: Yuriko, Mori, Fumiaki, Sato, Florin M, Selaru, Andreea, Olaru, Kellie, Perry, Martha C, Kimos, Gen, Tamura, Nagahide, Matsubara, Suna, Wang, Yan, Xu, Jing, Yin, Tong-Tong, Zou, Barbara, Leggett, Joanne, Young, Toshihiro, Nukiwa, O Colin, Stine, John M, Abraham, David, Shibata, Stephen J, Meltzer

Publikováno v: Cancer research. 62(13)

Microsatellite instability (MSI) within coding regions causes frameshift mutations (FSMs). This type of mutation may inactivate tumor suppressor genes in cancers with frequent MSI (MSI-H cancers). To identify novel FSMs in gastric carcinogenesis in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fb108cd6877bf836c45c599c77814ea8
https://pubmed.ncbi.nlm.nih.gov/12097267

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Artificial neural networks and gene filtering distinguish between global gene expression profiles of Barrett's esophagus and esophageal cancer

Autor: Yan, Xu, Florin M, Selaru, Jing, Yin, Tong Tong, Zou, Valentina, Shustova, Yuriko, Mori, Fumiaki, Sato, Thomas C, Liu, Andreea, Olaru, Suna, Wang, Martha C, Kimos, Kellie, Perry, Kena, Desai, Bruce D, Greenwald, Mark J, Krasna, David, Shibata, John M, Abraham, Stephen J, Meltzer

Publikováno v: Cancer research. 62(12)

cDNAmicroarrays, combined with bioinformatics analyses, are becomingincreasingly used in current medical research. Existing analytic methods,particularly those that are unsupervised, often have difficulty recognizing subtle differences among predefin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2e03152d7353c945db63a7955f3d6b0
https://pubmed.ncbi.nlm.nih.gov/12067993

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Activation of the esophagin promoter during esophageal epithelial cell differentiation

Autor: Stephen J. Meltzer, Yan Xu, John M. Abraham, A. Steven Fleisher, Suna Wang, Jing Yin, Dehe Kong, Rhonda F. Souza, Tong Tong Zou, Kara N. Smolinski

Publikováno v: Genomics. 79(6)

Esophagin is a member of the small proline-rich protein family of cell envelope precursor proteins, which are expressed during squamous cell differentiation. Esophagin is expressed at high levels in normal esophageal epithelium, but its expression is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d4777623c8b3c964dde54614ab5ff8
https://pubmed.ncbi.nlm.nih.gov/12036303

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Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon

Autor: John M. Abraham, Jing Yin, Elena Deacu, Thomas C. Liu, Tong Tong Zou, Stephen J. Meltzer, Valentina Shustova, Yuriko Mori, David Shibata, Florin M. Selaru, Andreea Olaru, Fumiaki Sato, Yan Xu, Suma Wang

Publikováno v: Oncogene. 21(31)

In order to discover global gene expression patterns characterizing subgroups of colon cancer, microarrays were hybridized to labeled RNAs obtained from seventeen colonic specimens (nine carcinomas and eight normal samples). Using a hierarchical aggl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e033b4a5a302f251ab1fcc32f6ab3f5f
https://pubmed.ncbi.nlm.nih.gov/12101425

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Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia

Autor: Jing Yin, James G. Herman, O. Colin Stine, Tong Tong Zou, John M. Abraham, Gen Tamura, Dehe Kong, Stephen J. Meltzer, A. Steven Fleisher, Asma Rashid, Satoshi Nishizuka, Keith T. Wilson, Stephen P. James, Manel Esteller

Publikováno v: Oncogene. 20(3)

A significant portion of gastric cancers exhibit defective DNA mismatch repair, manifested as microsatellite instability (MSI). High-frequency MSI (MSI-H) is associated with hypermethylation of the human mut-L homologue 1 (hMLH1) mismatch repair gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f4c4beb47fa302a164f206c3a784ab
https://pubmed.ncbi.nlm.nih.gov/11313962

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