Gefitinib and methotrexate to resolve tubal ectopic pregnancy: the GEM3 RCT

Autor: Moakes Catherine A, Tong Stephen, Middleton Lee J, Duncan W Colin, Mol Ben W, Whitaker Lucy H R, Jurkovic Davor, Coomarasamy Arri, Nunes Natalie, Holland Tom, Clarke Fiona, Sutherland Lauren C, Doust Ann M, Daniels Jane P, Horne Andrew W

Publikováno v: Efficacy and Mechanism Evaluation, Vol 10, Iss 01 (2023)

Background Tubal ectopic pregnancies can cause significant morbidity or even death. Current treatment is with methotrexate or surgery. However, methotrexate treatment can fail in approximately 30% of women. Gefitinib, an epidermal growth factor recep

Externí odkaz: https://doaj.org/article/7d03bbd52580498aa201def74ae60531

Using a decline in serum hCG between days 0–4 to predict ectopic pregnancy treatment success after single-dose methotrexate: a retrospective cohort study

Autor: Skubisz Monika, Dutton Philip, Duncan William Colin, Horne Andrew W, Tong Stephen

Publikováno v: BMC Pregnancy and Childbirth, Vol 13, Iss 1, p 30 (2013)

Abstract Background The current measure of treatment efficacy of single-dose methotrexate for ectopic pregnancy, is a fall in serum hCG of ≥15% between days 4–7 of treatment, which has a positive predictive value of 93% for treatment success. Two

Externí odkaz: https://doaj.org/article/72c1c9de3fd04a939f0d968250b97f3f

Has increased clinical experience with methotrexate reduced the direct costs of medical management of ectopic pregnancy compared to surgery?

Autor: Westaby Daniel T, Wu Olivia, Duncan W, Critchley Hilary OD, Tong Stephen, Horne Andrew W

Publikováno v: BMC Pregnancy and Childbirth, Vol 12, Iss 1, p 98 (2012)

Abstract Background There is a debate about the cost-efficiency of methotrexate for the management of ectopic pregnancy (EP), especially for patients presenting with serum human chorionic gonadotrophin levels of >1500 IU/L. We hypothesised that furth

Externí odkaz: https://doaj.org/article/2b20804a66a849dea4644005f80819f5

Rapid Determination of Trace Ethylene Glycol and Diethylene Glycol in Propylene Glycol-Contained Syrups by Ultrahigh-Performance Supercritical Fluid Chromatography-Mass Spectrometry after Precolumn Derivatization.

Autor: Zheng ST; Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, Nanjing 210009, China; Jiangsu Institute for Food and Drug Control, Nanjing 210019, China; NMPA Key Laboratory for Impurity Profile of Chemical Drugs, Nanjing 210019, China., Wang ZY; Jiangsu Institute for Food and Drug Control, Nanjing 210019, China; NMPA Key Laboratory for Impurity Profile of Chemical Drugs, Nanjing 210019, China., Liu Z; Nanjing Institute for Food and Drug Control, Nanjing 211198, China., Du Y; Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, Nanjing 210009, China. Electronic address: yingxiangdu@163.com., Cao L; Center for Inspection of Jiangsu Medical Products Administration, Nanjing 210019, China., Tang S; Department School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, China., Lee HK; Department School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, China; Department of Chemistry, National University of Singapore, Singapore 117543, Singapore. Electronic address: chmleehk@nus.edu.sg., Yuan Y; Jiangsu Institute for Food and Drug Control, Nanjing 210019, China; NMPA Key Laboratory for Impurity Profile of Chemical Drugs, Nanjing 210019, China., Shi HW; Jiangsu Institute for Food and Drug Control, Nanjing 210019, China; NMPA Key Laboratory for Impurity Profile of Chemical Drugs, Nanjing 210019, China. Electronic address: germain0906@gmail.com.

Publikováno v: Journal of chromatography. A [J Chromatogr A] 2024 Nov 22; Vol. 1737, pp. 465433. Date of Electronic Publication: 2024 Oct 10.

Past Is Prologue: The Essential Role of Advocacy in Shaping the Future of Family Medicine Research.

Autor: Liaw W; From the Department of Health Systems and Population Health Sciences, University of Houston Tilman J. Fertitta Family College of Medicine, Houston, TX (WL); Department of Family Medicine, University of Washington, Seattle, Washington (STT); Council of Academic Family Medicine, Washington, DC (ND). winstonrliaw@gmail.com., Tong ST; From the Department of Health Systems and Population Health Sciences, University of Houston Tilman J. Fertitta Family College of Medicine, Houston, TX (WL); Department of Family Medicine, University of Washington, Seattle, Washington (STT); Council of Academic Family Medicine, Washington, DC (ND)., DeJonghe N; From the Department of Health Systems and Population Health Sciences, University of Houston Tilman J. Fertitta Family College of Medicine, Houston, TX (WL); Department of Family Medicine, University of Washington, Seattle, Washington (STT); Council of Academic Family Medicine, Washington, DC (ND)., Wittenberg HR; From the Department of Health Systems and Population Health Sciences, University of Houston Tilman J. Fertitta Family College of Medicine, Houston, TX (WL); Department of Family Medicine, University of Washington, Seattle, Washington (STT); Council of Academic Family Medicine, Washington, DC (ND).

Publikováno v: Journal of the American Board of Family Medicine : JABFM [J Am Board Fam Med] 2024 Nov 15. Date of Electronic Publication: 2024 Nov 15.