Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Tong Ihn Lee"'
Autor:
Jurian Schuijers, John Colonnese Manteiga, Abraham Selby Weintraub, Daniel Sindt Day, Alicia Viridiana Zamudio, Denes Hnisz, Tong Ihn Lee, Richard Allen Young
Publikováno v:
Cell Reports, Vol 23, Iss 2, Pp 349-360 (2018)
Summary: Transcriptional dysregulation of the MYC oncogene is among the most frequent events in aggressive tumor cells, and this is generally accomplished by acquisition of a super-enhancer somewhere within the 2.8 Mb TAD where MYC resides. We find t
Externí odkaz:
https://doaj.org/article/550f4fbbf19649f2abe725687a117283
Autor:
Akdes Serin Harmancı, Mark W. Youngblood, Victoria E. Clark, Süleyman Coşkun, Octavian Henegariu, Daniel Duran, E. Zeynep Erson-Omay, Leon D. Kaulen, Tong Ihn Lee, Brian J. Abraham, Matthias Simon, Boris Krischek, Marco Timmer, Roland Goldbrunner, S. Bülent Omay, Jacob Baranoski, Burçin Baran, Geneive Carrión-Grant, Hanwen Bai, Ketu Mishra-Gorur, Johannes Schramm, Jennifer Moliterno, Alexander O. Vortmeyer, Kaya Bilgüvar, Katsuhito Yasuno, Richard A. Young, Murat Günel
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Meningiomas are mostly benign brain tumours with the potential for becoming atypical or malignant. Here, the authors show that primary atypical meningiomas are epigenetically and genetically distinct from benign and progressed tumours, highlighting p
Externí odkaz:
https://doaj.org/article/d27c23c5f6b847e4a5ce5684ebe1b356
Autor:
Brian J. Abraham, Denes Hnisz, Abraham S. Weintraub, Nicholas Kwiatkowski, Charles H. Li, Zhaodong Li, Nina Weichert-Leahey, Sunniyat Rahman, Yu Liu, Julia Etchin, Benshang Li, Shuhong Shen, Tong Ihn Lee, Jinghui Zhang, A. Thomas Look, Marc R. Mansour, Richard A. Young
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Sequencing initiatives have detected multiple types of mutations in cancer. Here the authors, analysing enhancer-targeting sequence data, show that small insertions in transcriptional enhancers are frequently found near oncogenes, and demonstrate how
Externí odkaz:
https://doaj.org/article/83aabc930e7b4c009b32aff780ab64f2
Autor:
Ana C. D’Alessio, Zi Peng Fan, Katherine J. Wert, Petr Baranov, Malkiel A. Cohen, Janmeet S. Saini, Evan Cohick, Carol Charniga, Daniel Dadon, Nancy M. Hannett, Michael J. Young, Sally Temple, Rudolf Jaenisch, Tong Ihn Lee, Richard A. Young
Publikováno v:
Stem Cell Reports, Vol 5, Iss 5, Pp 763-775 (2015)
Hundreds of transcription factors (TFs) are expressed in each cell type, but cell identity can be induced through the activity of just a small number of core TFs. Systematic identification of these core TFs for a wide variety of cell types is current
Externí odkaz:
https://doaj.org/article/047995cce35243f7b90bc348980aa00d
Autor:
Akdes Serin Harmancı, Mark W. Youngblood, Victoria E. Clark, Süleyman Coşkun, Octavian Henegariu, Daniel Duran, E. Zeynep Erson-Omay, Leon D. Kaulen, Tong Ihn Lee, Brian J. Abraham, Matthias Simon, Boris Krischek, Marco Timmer, Roland Goldbrunner, S. Bülent Omay, Jacob Baranoski, Burçin Baran, Geneive Carrión-Grant, Hanwen Bai, Ketu Mishra-Gorur, Johannes Schramm, Jennifer Moliterno, Alexander O. Vortmeyer, Kaya Bilgüvar, Katsuhito Yasuno, Richard A. Young, Murat Günel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
Nature Communications 8: Article number: 14433 (2017) Published online 14 February 2017; Updated 20 April 2018 In this Article, a subset of the H3K27ac ChIP-seq data (15 benign meningiomas and 2 dura samples (Sample IDs: MN-297, MN-288, MN-292, MN-16
Externí odkaz:
https://doaj.org/article/6f63b2d4e7c84e9b9c9b5b660f84a4ca
Autor:
Brian J. Abraham, Denes Hnisz, Abraham S. Weintraub, Nicholas Kwiatkowski, Charles H. Li, Zhaodong Li, Nina Weichert-Leahey, Sunniyat Rahman, Yu Liu, Julia Etchin, Benshang Li, Shuhong Shen, Tong Ihn Lee, Jinghui Zhang, A. Thomas Look, Marc R. Mansour, Richard A. Young
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 8: Article number:14385 (2017); Published: 9 February 2017; Updated: 1 June 2017 In the original version of Supplementary Data 1 associated with this Article, the list of predicted enhancer-associated insertions was inadvertentl
Externí odkaz:
https://doaj.org/article/a5144bbffd064084a1cb968c0fb0bb7e
Publikováno v:
Diabetes. 71
Insulin receptor (IR) signaling is central to normal metabolic control and is dysregulated in metabolic diseases such as type 2 diabetes. We have found that IR is incorporated into biomolecular condensates during the response to insulin stimulation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b64880dbe3c5e9095a727146542138e7
https://doi.org/10.2337/db22-1305-p
https://doi.org/10.2337/db22-1305-p
Autor:
Xin Tang, Gary LeRoy, Alicia V. Zamudio, Alessandra Dall’Agnese, Richard A. Young, Emile Wogram, Jurian Schuijers, Nancy M. Hannett, Jonathan E. Henninger, Tenzin Lungjangwa, Tong Ihn Lee, Jesse M. Platt, Eliot L. Coffey, Ozgur Oksuz, X. Shawn Liu, Styliani Markoulaki, Charles H. Li, Lena K. Afeyan, Rudolf Jaenisch, Devon S. Svoboda
Publikováno v:
Nature
Methyl CpG binding protein 2 (MeCP2) is a key component of constitutive heterochromatin, which is crucial for chromosome maintenance and transcriptional silencing1–3. Mutations in the MECP2 gene cause the progressive neurodevelopmental disorder Ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f51fc72bdd6c60ff1b8c95fcbf6cd08
https://doi.org/10.1038/s41586-020-2574-4
https://doi.org/10.1038/s41586-020-2574-4
Autor:
Yang Eric Guo, Brian J. Abraham, Tim-Michael Decker, Dylan J. Taatjes, Jenna K. Rimel, Phillip A. Sharp, Tong Ihn Lee, Charli B. Fant, John C. Manteiga, Krishna Shrinivas, Lena K. Afeyan, Benjamin R. Sabari, Richard A. Young, Jan-Hendrik Spille, Jonathan E. Henninger, Alessandra Dall’Agnese, Alicia V. Zamudio, Nancy M. Hannett, Ann Boija, Ibrahim I Cisse
Publikováno v:
Nature
The synthesis of pre-mRNA by RNA polymerase II (Pol II) involves the formation of a transcription initiation complex, and a transition to an elongation complex1–4. The large subunit of Pol II contains an intrinsically disordered C-terminal domain t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd05b7c69848ab64e299895bb7068c6d
https://doi.org/10.1038/s41586-019-1464-0
https://doi.org/10.1038/s41586-019-1464-0
Autor:
Salman F. Banani, Lena K. Afeyan, Susana W. Hawken, Jonathan E. Henninger, Alessandra Dall’Agnese, Victoria E. Clark, Jesse M. Platt, Ozgur Oksuz, Nancy M. Hannett, Ido Sagi, Tong Ihn Lee, Richard A. Young
Publikováno v:
Developmental cell. 57(14)
A multitude of cellular processes involve biomolecular condensates, which has led to the suggestion that diverse pathogenic mutations may dysregulate condensates. Although proof-of-concept studies have identified specific mutations that cause condens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2393c181b9a6d827d7a6e2e8d74f44e
https://pubmed.ncbi.nlm.nih.gov/35901780
https://pubmed.ncbi.nlm.nih.gov/35901780