Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Tong H. Lee"'
Publikováno v:
Behavioural Brain Research. 262:42-46
Cocaine abuse is associated with a high prevalence of nicotine dependence. In animals, nicotinic antagonists have been reported to block the development of cocaine behavioral sensitization and to attenuate cocaine place preference or self-administrat
Autor:
William C. Wetsel, Tong H. Lee, Paolo Mannelli, Steven T. Szabo, Ashwin A. Patkar, O. Barry Mangum, J. Corey Fowler, Wayne F. Beyer
Publikováno v:
Drug and Alcohol Dependence. 124:11-18
Psychostimulant abuse continues to present legal, socioeconomic and medical challenges as a primary psychiatric disorder, and represents a significant comorbid factor in major psychiatric and medical illnesses. To date, monotherapeutic drug treatment
Publikováno v:
Behavioural Brain Research. 223:227-232
Psychostimulant abuse represents a psychiatric disorder and societal concern that has been largely unamenable to therapeutic interventions. We have previously demonstrated that the 5-HT 3 antagonist ondansetron or non-selective 5-HT 2A/2C antagonist
Autor:
Qiang Chen, Tong H. Lee, Xiuwu Zhang, William C. Wetsel, Yangzhong Huang, Yingmiao Liu, Qi-An Sun, Bruce A. Sullenger, Gregory A. Michelotti
Publikováno v:
Journal of Neurochemistry. 108:147-157
Phosphorylation at glutamate receptor subunit 1(GluR1) Ser845 residue has been widely accepted to involve in GluR1-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking, but the in vivo evidence has not yet b
Publikováno v:
Brain Research. 1248:184-190
In traditional medicine, Panax ginseng has been used to treat various behavioral effects of psychostimulants (e.g., cocaine) and other drugs of abuse and to ameliorate withdrawal symptoms. The neurochemical bases for this efficacy, however, remain to
Publikováno v:
Journal of Neurochemistry. 107:679-689
Behavioral sensitization of psychostimulants was accompanied by alterations in a variety of biochemical molecules in different brain regions. However, which change is actually related to drug-produced sensitization lacks of accurate clarification. In
Autor:
Xiuwu Zhang, Qi An Sun, Yingmiao Liu, Xueying Xiong, Qiang Chen, Tong H. Lee, William C. Wetsel
Publikováno v:
Journal of Neuroscience Methods. 173:208-214
In this study we established conditional silencing of integrin-linked kinase (ILK) expression in Sprague-Dawley rat brain by microinjection of rAAV-2-carrying, Tet-On-regulated siRNA expression cassette into nucleus accumbens (NAc) core and induction
Autor:
Cindy Lazarus, Xueying Xiong, Tong H. Lee, Colin Davidson, Xiuwn Zhang, Qiang Chen, Everett H. Ellinwood
Publikováno v:
European Journal of Pharmacology. 573:100-110
Deprenyl, used clinically in Parkinson's disease, has multiple pharmacological effects which make it a good candidate to treat neurotoxicity. Thus, we investigated deprenyl's ability to attenuate methamphetamine-induced dopamine neurotoxicity. We als
Autor:
Ashwin A. Patkar, Everett H. Ellinwood, Rupa Gopalan, G. Daniel Weese, Cassandra Ahn, Qiang Chen, Colin Davidson, Tong H. Lee, Paolo Mannelli
Publikováno v:
European Journal of Pharmacology. 565:113-118
We have previously found the 5-HT 3 receptor antagonist ondansetron to be useful in reducing cocaine self-administration and cocaine induced sensitization in rats when given during cocaine withdrawal. More recently we have found the combination of th
Autor:
Tong H. Lee, William C. Wetsel, Yingmiao Liu, Everett H. Ellinwood, Qi An Sun, Xiuwu Zhang, Colin Davidson, Xueying Xiong, Qiang Chen
Publikováno v:
Biochemical and Biophysical Research Communications. 356:733-738
We have recently shown in rats that cocaine-induced behavioral sensitization can be reversed by a 5-day treatment with ondansetron given 3.5 h after daily pergolide injections. In this study we further investigated the molecular/neurochemical alterat