A 28-day oral dose toxicity study enhanced to detect endocrine effects of a purified technical pentabromodiphenyl ether (pentaBDE) mixture in Wistar rats

Autor: Helen Håkansson, Leo T.M. van der Ven, Ton van de Kuil, Pim E.G. Leonards, Josephus G. Vos, Wout Slob, Theo J. Visser, Aldert H. Piersma, Yvonne Fery, Rocío F. Cantón, Sabina Litens, Timo Hamers, Aart Verhoef, Silke Germer, Dieter Schrenk, Martin van den Berg

Publikováno v: van der Ven, L T M, van de Kuil, T, Verhoef, A, Leonards, P E G, Slob, W, Canton, R F, Germer, S, Hamers, T, Visser, T J, Litens, S, Hakansson, H, Fery, Y, Schrenk, D, van den Berg, M, Piersma, A H & Vos, J G 2008, ' A 28-day oral dose toxicity study enhanced to detect endocrine effects of a purified technical pentabromodiphenyl ether (pentaBDE) mixture in Wistar rats ', Toxicology, vol. 245, pp. 109-122 . https://doi.org/10.1016/j.tox.2007.12.016
Toxicology, 245(1-2), 109-122. Elsevier Ireland Ltd
Toxicology, 245, 109-122. Elsevier Ireland Ltd

A 28-day subacute oral toxicity study was performed in Wistar rats with a purified preparation of the commercial pentabromodiphenyl ether (pentaBDE), DE-71. The applied OECD407 protocol was enhanced for endocrine and immune parameters, and to enable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c573f472f917f0243ff405d3f471c808
https://doi.org/10.1016/j.tox.2007.12.016

Endocrine effects of tetrabromobisphenol-A (TBBPA) in Wistar rats as tested in a one-generation reproduction study and a subacute toxicity study

Autor: Cynthia M. Verwer, Frank H. de Jong, Martin van den Berg, Sabina Litens, Natalia Stern, Wout Slob, Josephus G. Vos, Pim E.G. Leonards, Rocío F. Cantón, Ute M.D. Schauer, Helen Håkansson, Hellmuth Lilienthal, Wolfgang Dekant, Aart Verhoef, Theo J. Visser, Aldert H. Piersma, Leo T.M. van der Ven, Ton van de Kuil

Publikováno v: Toxicology, 245(1-2), 76-89. Elsevier Ireland Ltd
van der Ven, L T M, van de Kuil, T, Verhoef, A, Verwer, C M, Lilienthal, H, Leonards, P E G, Schauer, U M D, Canton, R F, Litens, S, de Jong, F H, Visser, T J, Dekant, W, Stern, N, Hakansson, H, Slob, W, van den Berg, M, Vos, J G & Piersma, A H 2008, ' Endocrine effects of tetrabromobisphenol-A (TBBPA) in Wistar rats as tested in a one-generation reproduction study and a subacute toxicity study ', Toxicology, vol. 245, no. 1-2, pp. 76-89 . https://doi.org/10.1016/j.tox.2007.12.009

Endocrine effects of the brominated flame retardant tetrabromobisphenol-A (TBBPA) were studied in a one-generation reproduction assay in Wistar rats via repeated dietary exposure, applying eight dose groups at 0-3-10-30-100-300-1000-3000 mg/kg body w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b0d41ed1f1ddff4a74e83d64d11c9c
https://doi.org/10.1016/j.tox.2007.12.009

Increased frequencies of diploid sperm detected by multicolour FISH after treatment of rats with carbendazim without micronucleus induction in peripheral blood erythrocytes

Autor: Joyce M. de Stoppelaar, Mirjam Bedaf, Jan van Benthem, Wout Slob, Barbara Hoebee, Georges R. Mohn, Henny W. Verharen, Ton van de Kuil

Publikováno v: Mutagenesis. 14:621-632

The purpose of the present study was to determine the effect of a single oral dose of carbendazim (CARB) on the frequencies of numerical chromosome aberrations in sperm and on micronuclei in peripheral blood erythrocytes of rats. Dual colour FISH on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da16094f7b0d7e0007227c9a6461075
https://doi.org/10.1093/mutage/14.6.621

A 28-day oral dose toxicity study enhanced to detect endocrine effects of hexabromocyclododecane in wistar rats

Autor: Maria Herlin, Ton van de Kuil, Aldert H. Piersma, Aart Verhoef, Timo Hamers, Helen Håkansson, Theo J. Visser, Wout Slob, Leo T.M. van der Ven, Hanna Olausson, Josephus G. Vos, Pim E.G. Leonards

Publikováno v: Toxicological Sciences, 94(2), 281-292. Oxford University Press
van der Ven, L T M, Verhoef, A, van de Kuil, T, Slob, W, Leonards, P E G, Visser, T J, Hamers, T, Herlin, M, Hakansson, H, Olausson, H, Piersma, A H & Vos, J G 2006, ' A 28-day oral dose toxicity study enhanced to detect endocrine effects of hexabromocyclododecane in wistar rats ', Toxicological Sciences, vol. 94, no. 2, pp. 281-292 . https://doi.org/10.1093/toxsci/kfl113

A 28-day repeated dose study in rats (OECD407) enhanced for endocrine and immune parameters was performed with hexabromocyclododecane (HBCD). Rats were exposed by daily gavage to HBCD dissolved in corn oil in 8 dose groups with doses ranging between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0590435c0fb58d2da00496f829b39e
https://research.vu.nl/en/publications/fe8237e7-01ce-4367-9a5b-da8cb2a2ee8e

Pertussis toxin-induced histamine sensitisation: an aspecific phenomenon independent from the nitric oxide system?

Autor: Ton van de Kuil, Cornelia E. van Meijeren, Coenraad F.M. Hendriksen, Wim Vleeming, Dick J. De Wildt, Anne-Loes Gerards

Publikováno v: European journal of pharmacology. 493(1-3)

Mechanisms were studied initially to develop an in vitro safety test for detecting pertussis toxin toxicity in acellular pertussis vaccines based on the histamine sensitisation test. Maximal contractions and sensitivities to different agonists and ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0025c748bea5e76ccba1a24d7c786f41
https://pubmed.ncbi.nlm.nih.gov/15189775