Zobrazeno 1 - 10 of 61 pro vyhledávání: '"Ton de Wit"'
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Akademický článek
Specificity protein 2 (Sp2) is essential for mouse development and autonomous proliferation of mouse embryonic fibroblasts.
Autor: Frank Baur, Kerstin Nau, Dennis Sadic, Lena Allweiss, Hans-Peter Elsässer, Nynke Gillemans, Ton de Wit, Imme Krüger, Marion Vollmer, Sjaak Philipsen, Guntram Suske
Publikováno v: PLoS ONE, Vol 5, Iss 3, p e9587 (2010)
BACKGROUND: The zinc finger protein Sp2 (specificity protein 2) is a member of the glutamine-rich Sp family of transcription factors. Despite its close similarity to Sp1, Sp3 and Sp4, Sp2 does not bind to DNA or activate transcription when expressed
Externí odkaz: https://doaj.org/article/9310873f1b3943e4bef3e5cde6692409
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3
Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia
Autor: Michiel Coesmans, Najaf Amin, Christian G. Bouwkamp, Aviva Nijburg, Timothy Wu, Maarouf Baghdadi, H. Berna Beverloo, Nilhan Gunhanlar, Guido J. Breedveld, Bas Lendemeijer, Veerle Bergink, P. Roberto Bakker, Carolyn D. Langen, Edwin Mientjes, Witte J.G. Hoogendijk, Ype Elgersma, Frans W. Verheijen, A.T. Spijker, André G. Uitterlinden, Simone Olgiati, Femke M.S. de Vrij, M. Arfan Ikram, Ton de Wit, Vincenzo Bonifati, Henning Tiemeier, Loes M. Olde Loohuis, Dan Cohen, Cornelia M. van Duijn, Rob M. Kok, Guy Shpak, Mehrnaz Ghazvini, Tonya White, P. M. Judith Haffmans, Meike W. Vernooij, Tracy Li, Erik Hoencamp, Marialuisa Quadri, Albert Hofman, Ben Distel, Joost Gribnau, Shreekara Gopalakrishna, Steven A. Kushner, Jacob A. S. Vorstman
Publikováno v: Molecular Psychiatry, 24(5), 757-771. Nature Publishing Group
Molecular psychiatry, 24, 757-771. Nature Publishing Group
Molecular Psychiatry
Schizophrenia is highly heritable, yet its underlying pathophysiology remains largely unknown. Among the most well-replicated findings in neurobiological studies of schizophrenia are deficits in myelination and white matter integrity; however, direct
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47c11de95e90cc589d840a6752d3ce2
https://pure.eur.nl/en/publications/995aa584-ec6f-4e06-81d1-54836f7e439e
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4
The human desmin locus: Gene organization and LCR-mediated transcriptional control
Autor: Kostas Triantaphyllopoulos, Helen Todd, Eleni Makrinou, Michael Antoniou, Ton de Wit, Frank Grosveld, Terence A. Partridge, Jennifer L.Y. Tam, Jennifer E. Morgan, Selina Raguz
Publikováno v: Genomics, 87(6), 733-746. Academic Press
Locus control regions (LCRs) are defined by their ability to confer reproducible physiological levels of transgene expression in mice and therefore thought to possess the ability to generate dominantly a transcriptionally active chromatin structure.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baab9ed57c22718dea93e1a12ba44d3c
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5
Expression of theLy-6A(Sca-1)lacZtransgene in mouse haematopoietic stem cells and embryos
Autor: John Kong-a-San, Ton de Wit, Marella F. T. R. de Bruijn, Xiaoqian Ma, Marian Peeters, Corne Snoijs, Catherine Robin, Elaine Dzierzak
Publikováno v: British Journal of Haematology. 116:401-408
Summary. The Sca-1 surface glycoprotein is used routinely as a marker for haematopoietic stem cell enrichment. Two allelic genes, Ly-6A and Ly-6E, encode this marker and appear to be differentially regulated in haematopoietic cells and haematopoietic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1e1472f57a0f22d64b9f5e689f5108b
https://doi.org/10.1046/j.1365-2141.2002.03250.x
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6
[Untitled]
Autor: Dubravka Drabek, Ton de Wit, Frank Grosveld
Publikováno v: Transgenic Research. 11:305-310
Double-stranded RNA (dsRNA) has been shown to interfere with the function of specific genes in various invertebrate species. The application of dsRNA interference (RNAi) in vertebrates (zebrafish and mouse) is still limited to embryos and it is not c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80c3b5f5c57e3752f0653755b7eda74b
https://doi.org/10.1023/a:1015687008357
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7
Altered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the beta-globin locus control region in vivo
Autor: Rita Tewari, Frank Grosveld, Robbert J. Rottier, Sjaak Philipsen, Ton de Wit, Nynke Gillemans, Fokke Lindeboom, Mark Wijgerde
Publikováno v: Genes & Development, 12, 2863-2873. Cold Spring Harbor Laboratory Press
The locus control region of the β-globincluster contains five DNase I hypersensitive sites (5′HS1–5) required for locus activation. 5′HS3 contains six G-rich motifs that are essential for its activity. Members of a protein family, characterize
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be477132c361e9e38832f88ba94aeaf
https://pure.eur.nl/en/publications/eb945d88-cf74-4fd7-8b8b-fdf229c6b9a2
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8
Correction of the X-linked immunodeficiency phenotype by transgenic expression of human Bruton tyrosine kinase under the control of the class II major histocompatibility complex Ea locus control region
Autor: Huub F. J. Savelkoul, Dubravka Drabek, Frank Grosveld, Rudolf W. Hendriks, Ton de Wit, Gemma M. Dingjan, Selina Raguz
Publikováno v: Proceedings of the National Academy of Sciences of the United States of Ame, 94, 610-615. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 94(2), 610-615
Proceedings of the National Academy of Sciences of the United States of America 94 (1997) 2
Bruton tyrosine kinase (Btk) is essential for the development of pre-B cells to mature B cell stages.Btk-deficient mice manifest an X-linked immunodeficiency (xid) defect characterized by a reduction of peripheral IgMlowIgDhighB cells, a lack of peri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1148428f083a21c11adced55a0b0691b
https://hdl.handle.net/1765/73808
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9
Intracellularly expressed single-domain antibody against p15 matrix protein prevents the production of porcine retroviruses
Autor: Sylvia Dekker, Frank Grosveld, George Panayotou, Wendy Toussaint, Ton de Wit, Pim Visser, Dubravka Drabek
Publikováno v: Journal of Virology, 77(22), 12132-12139. American Society for Microbiology
The presence of porcine endogenous retroviruses presents a potential risk of transmission of infectious diseases (xenozoonosis) if tissues and organs from genetically modified pigs are to be used in xenotransplantation. Here, we report that intracell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904ac818b20b0481728417ddc55f4ddd
https://pubmed.ncbi.nlm.nih.gov/14581550
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10
Expression of the Ly-6A (Sca-1) lacZ transgene in mouse haematopoietic stem cells and embryos
Autor: Xiaoqian, Ma, Marella, de Bruijn, Catherine, Robin, Marian, Peeters, John, Kong-A-San, Ton, de Wit, Corne, Snoijs, Elaine, Dzierzak
Publikováno v: British journal of haematology. 116(2)
The Sca-1 surface glycoprotein is used routinely as a marker for haematopoietic stem cell enrichment. Two allelic genes, Ly-6A and Ly-6E, encode this marker and appear to be differentially regulated in haematopoietic cells and haematopoietic stem cel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5cee520ae8b395924469ba2e5a9263ef
https://pubmed.ncbi.nlm.nih.gov/11841445
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