Výsledky vyhledávání - "Ton Rullmann"

Autor: Ton Rullmann, Wynand Alkema, Andrea van Elsas

Publikováno v: Expert Opinion on Therapeutic Targets, 10(5), 635-638. Ashley

Genomics has multiplied the number of targets for new therapeutic interventions, but this has not yet lead to a marked increase of pharma pipeline outputs. The complexity of protein function in higher order biological systems is often underestimated.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b51fefc1d64f1d7d58d817e0d35722
https://doi.org/10.1517/14728222.10.5.635

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Autor: Jurgen F. Doreleijers, Ton Rullmann, Robert Kaptein, Mia L. Raves

Publikováno v: Journal of Biomolecular NMR. 14:123-132

The completeness of experimentally observed NOE restraints of a set of 97 NMR protein structures deposited in the PDB has been assessed. Completeness is defined as the ratio of the number of experimentally observed NOEs and the number of 'expected NO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b25ef921240226bb1edb3852066c57a6
https://doi.org/10.1023/a:1008335423527

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Identification of new biomarker candidates for glucocorticoid induced insulin resistance using literature mining

Autor: Stefan Verhoeven, René C. van Schaik, Jacob de Vlieg, Wynand Alkema, Wilco W. M. Fleuren, Tim Hulsen, Erik J M Toonen, Ton Rullmann, Raoul Frijters

Publikováno v: BioData Mining
BioData Mining, 6(1). BioMed Central
BioData Mining, Vol 6, Iss 1, p 2 (2013)
Biodata Mining, 6, 1, pp. 2
Biodata Mining, 6, 2

Background Glucocorticoids are potent anti-inflammatory agents used for the treatment of diseases such as rheumatoid arthritis, asthma, inflammatory bowel disease and psoriasis. Unfortunately, usage is limited because of metabolic side-effects, e.g.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d66a5074bfc550ffebc4de1a1292854
https://hdl.handle.net/2066/111355

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Assessing the metabolic effects of prednisolone in healthy volunteers using urine metabolic profiling

Autor: Age K. Smilde, Thomas Hankemeier, Ton Rullmann, Thijs Mp van Iersel, Ruud Berger, Wynand Alkema, Raymond Ramaker, Ewa Szymańska, Wim H. A. Dokter, Sandrine Ellero-Simatos

Publikováno v: Genome Medicine, 4(11). BioMed Central
Genome Medicine, 4
Genome Medicine

BACKGROUNDGlucocorticoids, such as prednisolone, are widely used anti-inflammatory drugs, but therapy is hampered by a broad range of metabolic side effects including skeletal muscle wasting and insulin resistance. Therefore, development of improved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7bfdb59cb14bd61396fe98e6c7ba072
https://doi.org/10.1186/gm395

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Autor: Jan Polman, Rob Jelier, Antoine Veldhoven, Stefan Verhoeven, Guido Jenster, Sjozef van Baal, Ton Rullmann, Blaise T. F. Alako

Publikováno v: BMC Bioinformatics. 6:51

High throughput microarray analyses result in many differentially expressed genes that are potentially responsible for the biological process of interest. In order to identify biological similarities between genes, publications from MEDLINE were iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dcf8c6ae08934a9909e5b672c329dec6
https://doi.org/10.1186/1471-2105-6-51

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