Zobrazeno 1 - 10
of 1 456
pro vyhledávání: '"Ton N"'
Autor:
Kaspar Bresser, Benoit P. Nicolet, Anita Jeko, Wei Wu, Fabricio Loayza-Puch, Reuven Agami, Albert J.R. Heck, Monika C. Wolkers, Ton N. Schumacher
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114418- (2024)
Externí odkaz:
https://doaj.org/article/fc2ad68cdcef48c484d105aeedaca262
Autor:
Jos Urbanus, Jason Cosgrove, Joost B. Beltman, Yuval Elhanati, Rafael A. Moral, Cecile Conrad, Jeroen W. van Heijst, Emilie Tubeuf, Arno Velds, Lianne Kok, Candice Merle, Jens P. Magnusson, Léa Guyonnet, Jonas Frisén, Silvia Fre, Aleksandra M. Walczak, Thierry Mora, Heinz Jacobs, Ton N. Schumacher, Leïla Perié
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Ageing is associated with changes in the cellular composition of the immune system. During ageing, hematopoietic stem and progenitor cells (HSPCs) that produce immune cells are thought to decline in their regenerative capacity. However, HSPC
Externí odkaz:
https://doaj.org/article/59862cc7f88545bf963a5cd524bcd9f4
Autor:
Lisanne M. Roelofsen, Paula Voabil, Marjolein de Bruijn, Petra Herzig, Alfred Zippelius, Ton N. Schumacher, Daniela S. Thommen
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102282- (2023)
Summary: The lack of suitable models currently hampers our understanding of how the tumor microenvironment responds to immunotherapy treatment. Here, we present a protocol for ex vivo culture of patient-derived tumor fragments (PDTFs). We describe th
Externí odkaz:
https://doaj.org/article/c2276a0502114ffd841cacb2749b9c77
Autor:
Joris L. Vos, Joris B. W. Elbers, Oscar Krijgsman, Joleen J. H. Traets, Xiaohang Qiao, Anne M. van der Leun, Yoni Lubeck, Iris M. Seignette, Laura A. Smit, Stefan M. Willems, Michiel W. M. van den Brekel, Richard Dirven, M. Baris Karakullukcu, Luc Karssemakers, W. Martin C. Klop, Peter J. F. M. Lohuis, Willem H. Schreuder, Ludi E. Smeele, Lilly-Ann van der Velden, I. Bing Tan, Suzanne Onderwater, Bas Jasperse, Wouter V. Vogel, Abrahim Al-Mamgani, Astrid Keijser, Vincent van der Noort, Annegien Broeks, Erik Hooijberg, Daniel S. Peeper, Ton N. Schumacher, Christian U. Blank, Jan Paul de Boer, John B. A. G. Haanen, Charlotte L. Zuur
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Immune checkpoint blockade has become standard care for patients with recurrent metastatic head and neck squamous cell carcinoma (HNSCC). Here the authors present the results of a non-randomized phase Ib/IIa trial, reporting safety and efficacy of ne
Externí odkaz:
https://doaj.org/article/761c20eac4bf4e0f8dc9495fdeadff61
Autor:
Kaspar Bresser, Meike E. W. Logtenberg, Mireille Toebes, Natalie Proost, Justin Sprengers, Bjorn Siteur, Manon Boeije, Lona J. Kroese, Ton N. Schumacher
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
The enzyme glutaminyl-peptide cyclotransferase-like protein (QPCTL) catalyzes the formation of pyroglutamate residues at the NH2-terminus of proteins, thereby influencing their biological properties. A number of studies have implicated QPCTL in the r
Externí odkaz:
https://doaj.org/article/47981d31c5594a39bf65905b145da91d
Autor:
Anastasia Gangaev, Steven L. C. Ketelaars, Olga I. Isaeva, Sanne Patiwael, Anna Dopler, Kelly Hoefakker, Sara De Biasi, Lara Gibellini, Cristina Mussini, Giovanni Guaraldi, Massimo Girardis, Cami M. P. Talavera Ormeno, Paul J. M. Hekking, Neubury M. Lardy, Mireille Toebes, Robert Balderas, Ton N. Schumacher, Huib Ovaa, Andrea Cossarizza, Pia Kvistborg
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Many viral antigens have been identified in patients with COVID-19 patients, but which of these result in meaningful immune responses is unclear. Here the authors identify a range of SARS-CoV-2 CD8+ T cell responses across patients including a respon
Externí odkaz:
https://doaj.org/article/2ce4c1ed10aa40a0a43f6286be3ee6c6
Autor:
Elisa Matas-Rico, Elselien Frijlink, Irene van der Haar Àvila, Apostolos Menegakis, Maaike van Zon, Andrew J. Morris, Jan Koster, Fernando Salgado-Polo, Sander de Kivit, Telma Lança, Antonio Mazzocca, Zoë Johnson, John Haanen, Ton N. Schumacher, Anastassis Perrakis, Inge Verbrugge, Joost H. van den Berg, Jannie Borst, Wouter H. Moolenaar
Publikováno v:
Cell Reports, Vol 37, Iss 7, Pp 110013- (2021)
Summary: Autotaxin (ATX; ENPP2) produces lysophosphatidic acid (LPA) that regulates multiple biological functions via cognate G protein-coupled receptors LPAR1-6. ATX/LPA promotes tumor cell migration and metastasis via LPAR1 and T cell motility via
Externí odkaz:
https://doaj.org/article/e9e9408a389a42bbba3e0b1045703cf7
Autor:
Francisco Caiado, Diogo Maia-Silva, Carolina Jardim, Nina Schmolka, Tânia Carvalho, Cláudia Reforço, Rita Faria, Branka Kolundzija, André E. Simões, Tuncay Baubec, Christopher R. Vakoc, Maria Gomes da Silva, Markus G. Manz, Ton N. Schumacher, Håkan Norell, Bruno Silva-Santos
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The development of post-chemotherapy resistance is a significant issue in the management of AML. Here, Caiado et al. suggest that the issue might be circumvented via upfront combination with hypomethylating agents that shape the clonal dynamics and t
Externí odkaz:
https://doaj.org/article/b7dfc820cd8046b7b9099018be4d92e6
Autor:
Annelies Jorritsma-Smit, Michel W J M Wouters, Bianca Heemskerk, Nienke van Rooij, Pia Kvistborg, John B A G Haanen, Joost H van den Berg, Raquel Gomez-Eerland, Samira Michels, Maaike van Zon, Renate de Boer, Noor A M Bakker, Marit M van Buuren, Hergen Spits, Remko Schotte, Henk Mallo, Matthias Karger, Joris A van der Hage, Loes M Pronk, Marnix H Geukes Foppen, Christian U Blank, Jos H Beijnen, Bastiaan Nuijen, Ton N Schumacher
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Purpose Execute a phase I/II feasibility study with TIL therapy in metastatic melanoma at the Netherlands Cancer Institute, with the goal to assess feasibility and potential value of a randomized phase III trial.Experimental Ten patients were treated
Externí odkaz:
https://doaj.org/article/dcfa2791fafa4572a3dce6276ee8be68
Autor:
Annegien Broeks, Ines Pires da Silva, Sarah Warren, Pia Kvistborg, Georgina V Long, Richard A Scolyer, Christian U Blank, Esmee P Hoefsmit, Elisa A Rozeman, Trieu My Van, Petros Dimitriadis, Jordan W Conway, Jacqueline E van der Wal, Steven L C Ketelaars, Kaspar Bresser, Ron M Kerkhoven, Jason W Reeves, Ellen W Kapiteijn, Ton N M Schumacher
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background The profound disparity in response to immune checkpoint blockade (ICB) by cutaneous melanoma (CM) and uveal melanoma (UM) patients is not well understood. Therefore, we characterized metastases of CM and UM from the same metastatic site (l
Externí odkaz:
https://doaj.org/article/57566697358f40ef905dd40c8195aef6