Zobrazeno 1 - 10
of 314
pro vyhledávání: '"Tomoyuki Yoshida"'
Autor:
Lin-Yu Li, Ayako Imai, Hironori Izumi, Ran Inoue, Yumie Koshidaka, Keizo Takao, Hisashi Mori, Tomoyuki Yoshida
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-14 (2024)
Abstract Neuroligin (NLGN) 3 is a postsynaptic cell adhesion protein organizing synapse formation through two different types of transsynaptic interactions, canonical interaction with neurexins (NRXNs) and a recently identified noncanonical interacti
Externí odkaz:
https://doaj.org/article/2f5b6e36fa4e4ebf92091db9bfc84fd5
Developmental synapse pathology triggered by maternal exposure to the herbicide glufosinate ammonium
Autor:
Hironori Izumi, Maina Demura, Ayako Imai, Ryohei Ogawa, Mamoru Fukuchi, Taisaku Okubo, Toshihide Tabata, Hisashi Mori, Tomoyuki Yoshida
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Environmental and genetic factors influence synapse formation. Numerous animal experiments have revealed that pesticides, including herbicides, can disturb normal intracellular signals, gene expression, and individual animal behaviors. However, the m
Externí odkaz:
https://doaj.org/article/d626179b6d5848d5b44a78364229ed82
Autor:
Xiance Ni, Ran Inoue, Yi Wu, Tomoyuki Yoshida, Keisuke Yaku, Takashi Nakagawa, Takashi Saito, Takaomi C. Saido, Keizo Takao, Hisashi Mori
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
BackgroundNeurodegenerative processes in Alzheimer’s disease (AD) are associated with excitotoxicity mediated by the N-methyl-D-aspartate receptor (NMDAR). D-Serine is an endogenous co-agonist necessary for NMDAR-mediated excitotoxicity. In the mam
Externí odkaz:
https://doaj.org/article/37bb76bd23ec431084d78931faea5334
Autor:
Keisuke Yaku, Sailesh Palikhe, Hironori Izumi, Tomoyuki Yoshida, Keisuke Hikosaka, Faisal Hayat, Mariam Karim, Tooba Iqbal, Yasuhito Nitta, Atsushi Sato, Marie E. Migaud, Katsuhiko Ishihara, Hisashi Mori, Takashi Nakagawa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nicotinamide riboside (NR) is a NAD + precursor exhibiting beneficial effects against aging. Here the authors demonstrate that orally administered NR increases NAD + levels in a diphasic manner and that bone marrow stromal cell antigen 1 plays a cruc
Externí odkaz:
https://doaj.org/article/a876a5bfafc342e5ae46b26347552ed1
Autor:
Tomoyuki Yoshida, Atsushi Yamagata, Ayako Imai, Juhyon Kim, Hironori Izumi, Shogo Nakashima, Tomoko Shiroshima, Asami Maeda, Shiho Iwasawa-Okamoto, Kenji Azechi, Fumina Osaka, Takashi Saitoh, Katsumi Maenaka, Takashi Shimada, Yuko Fukata, Masaki Fukata, Jumpei Matsumoto, Hisao Nishijo, Keizo Takao, Shinji Tanaka, Shigeo Okabe, Katsuhiko Tabuchi, Takeshi Uemura, Masayoshi Mishina, Hisashi Mori, Shuya Fukai
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Mutations of Neuroligin 3 (NLGN3) have been associated with autism spectrum disorder (ASD). Here, the authors identify a previously undescribed interaction between NLGN3 and a splice variant of protein tyrosine phosphatase δ (PTP δ) and its role in
Externí odkaz:
https://doaj.org/article/088ec8c07114426fb988df9303a95e47
Autor:
Takeshi Uemura, Emi Suzuki-Kouyama, Shiori Kawase, Taiga Kurihara, Misato Yasumura, Tomoyuki Yoshida, Shuya Fukai, Maya Yamazaki, Peng Fei, Manabu Abe, Masahiko Watanabe, Kenji Sakimura, Masayoshi Mishina, Katsuhiko Tabuchi
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110624- (2022)
Summary: Neurexins (NRXNs) are key presynaptic cell adhesion molecules that regulate synapse formation and function via trans-synaptic interaction with postsynaptic ligands. Here, we generate cerebellar granule cell (CGC)-specific Nrxn triple-knockou
Externí odkaz:
https://doaj.org/article/0a9c724aca2349bf9282e563b22cbc56
Autor:
Kanako Ishizuka, Tomoyuki Yoshida, Takeshi Kawabata, Ayako Imai, Hisashi Mori, Hiroki Kimura, Toshiya Inada, Yuko Okahisa, Jun Egawa, Masahide Usami, Itaru Kushima, Mako Morikawa, Takashi Okada, Masashi Ikeda, Aleksic Branko, Daisuke Mori, Toshiyuki Someya, Nakao Iwata, Norio Ozaki
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 12, Iss 1, Pp 1-16 (2020)
Abstract Background Rare genetic variants contribute to the etiology of both autism spectrum disorder (ASD) and schizophrenia (SCZ). Most genetic studies limit their focus to likely gene-disrupting mutations because they are relatively easier to inte
Externí odkaz:
https://doaj.org/article/e74c4827f25246839c35ab5f49759197
Autor:
Maiko Wakita, Atsushi Yamagata, Tomoko Shiroshima, Hironori Izumi, Asami Maeda, Mizuki Sendo, Ayako Imai, Keiko Kubota, Sakurako Goto-Ito, Yusuke Sato, Hisashi Mori, Tomoyuki Yoshida, Shuya Fukai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Synaptic organizers are cell-adhesion molecules capable of inducing synaptic differentiation through transsynaptic interactions. Here the authors present the crystal structure of the intracellular interaction between the synaptic organizer PTPδ and
Externí odkaz:
https://doaj.org/article/f3a3b04487b0410792c518a75d28e75e
Autor:
Atsushi Yamagata, Sakurako Goto-Ito, Yusuke Sato, Tomoko Shiroshima, Asami Maeda, Masahiko Watanabe, Takashi Saitoh, Katsumi Maenaka, Tohru Terada, Tomoyuki Yoshida, Takeshi Uemura, Shuya Fukai
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) function as postsynaptic organizers that induce excitatory synapses. Here authors solve the crystal structure of LRRTM2 in complex with its ligand Nrxn1β and shed light on how selective bi
Externí odkaz:
https://doaj.org/article/6a3dc0e46ef84edea9ccf79ebc62bca0
Autor:
Nariaki Miyao, Yukiko Hata, Hironori Izumi, Ryo Nagaoka, Yuko Oku, Ichiro Takasaki, Taisuke Ishikawa, Shinya Takarada, Mako Okabe, Hideyuki Nakaoka, Keijiro Ibuki, Sayaka Ozawa, Tomoyuki Yoshida, Hideyuki Hasegawa, Naomasa Makita, Naoki Nishida, Hisashi Mori, Fukiko Ichida, Keiichi Hirono
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0227393 (2020)
BackgroundTBX5 is a transcription factor that has an important role in development of heart. TBX5 variants in the region encoding the T-box domain have been shown to cause cardiac defects, such as atrial septal defect or ventricular septal defect, wh
Externí odkaz:
https://doaj.org/article/809709f73e3443efbc25317e9318720c