Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Tomoyuki Yasunaga"'
Autor:
Masaaki Hirano, Kazushige Ohno, Jun-Ichi Shishikura, Takenori Kimura, Tomoyuki Yasunaga, Hiroshi Inami, Hiroshi Yamashita, Shuichi Sakamoto
Publikováno v:
Chemical and Pharmaceutical Bulletin. 67:699-706
In our search for novel orally active α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists, we found that conversion of an allyl group in the lead compound 2-[allyl(4-methylphenyl)amino]-4H-pyrido[3,2-e][1,3]thiazin-4-one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e475c6e1e169b5d25934aacba33e548
https://doi.org/10.1248/cpb.c18-00977
https://doi.org/10.1248/cpb.c18-00977
Autor:
Hiroshi, Inami, Jun-Ichi, Shishikura, Tomoyuki, Yasunaga, Masaaki, Hirano, Takenori, Kimura, Hiroshi, Yamashita, Kazushige, Ohno, Shuichi, Sakamoto
Publikováno v:
Chemicalpharmaceutical bulletin. 67(7)
In our search for novel orally active α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists, we found that conversion of an allyl group in the lead compound 2-[allyl(4-methylphenyl)amino]-4H-pyrido[3,2-e][1,3]thiazin-4-one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aa7e1595fe22ef7a20db9ba22ceb3ece
https://pubmed.ncbi.nlm.nih.gov/31257325
https://pubmed.ncbi.nlm.nih.gov/31257325
Autor:
Jun-Ichi Shishikura, Tomoyuki Yasunaga, Shuichi Sakamoto, Kota Kato, Hiroshi Inami, Hiroshi Yamashita, Kazushige Ohno
Publikováno v:
Bioorganicmedicinal chemistry. 23(8)
As part of a program aimed at discovering orally active 2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonists, we screened our compound library and identified 2-[allyl(4-methylphenyl)amino]-4H-pyrido[3,2-e][1,3]thiazin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81474fc65dc8ae1a4ce63208cdddacd3
https://pubmed.ncbi.nlm.nih.gov/25792143
https://pubmed.ncbi.nlm.nih.gov/25792143
Publikováno v:
Synthetic Communications. 27:4245-4253
Abstract: Novel 8-hydroxy-4-oxochroman derivatives were prepared from appropriate 4-chromanones via the Baeyer-Villiger oxidation followed by an intramolecular Fries rearrangement.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8ee7a2efbdf398027006cca1b7ff8a9
https://doi.org/10.1080/00397919708005048
https://doi.org/10.1080/00397919708005048
Autor:
Tokio Yamaguchi, Tamako Nomura, Shin-ichi Tsukamoto, Ryo Naito, Toshiyasu Mase, Tomoyuki Yasunaga, Toru Kontani
Publikováno v:
ChemInform. 28
A series of N-[2-[(substituted chroman-8-yl)oxy]ethyl]-4-(4-methoxyphenyl)butylamines was prepared and examined for their 5-HT1A receptor antagonist activity. The parent compound 3a and seven analo...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf63c4d93a57f7ee5679b04523f9058e
https://doi.org/10.1002/chin.199732118
https://doi.org/10.1002/chin.199732118
Publikováno v:
ChemInform. 29
Abstract: Novel 8-hydroxy-4-oxochroman derivatives were prepared from appropriate 4-chromanones via the Baeyer-Villiger oxidation followed by an intramolecular Fries rearrangement.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20d8ec98fc4d9ac9b9ac5f1da3a1fca8
https://doi.org/10.1002/chin.199817150
https://doi.org/10.1002/chin.199817150
Autor:
Toshiyasu Mase, Ryo Naito, Tokio Yamaguchi, Shin-ichi Tsukamoto, Takenori Kimura, Tamako Nomura, Tomoyuki Yasunaga, Toru Kontani, T. Wanibuchi, Hiroshi Yamashita
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::639620dd9d51229402d8ef6db3c7fb71
https://doi.org/10.1002/chin.199846154
https://doi.org/10.1002/chin.199846154
Autor:
Toru Kontani, Tamako Nomura, Takenori Kimura, Tokio Yamaguchi, Fumikazu Wanibuchi, Tomoyuki Yasunaga, Toshiyasu Mase, Shin-ichi Tsukamoto, Ryo Naito, Hiroshi Yamashita
Publikováno v:
Journal of medicinal chemistry. 41(15)
A series of novel 6-fluorochroman derivatives was prepared and evaluated as antagonists for the 5-HT1A receptor. N-2-[[(6-Fluorochroman-8-yl)oxy]ethyl]-4-(4-methoxyphenyl)butylami ne (3; J. Med. Chem. 1997, 40, 1252-1257) was chosen as a lead, and st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd090d639d9eb724c7a8b456f4b5b2f1
https://pubmed.ncbi.nlm.nih.gov/9667967
https://pubmed.ncbi.nlm.nih.gov/9667967
Autor:
Tokio Yamaguchi, Tamako Nomura, Tomoyuki Yasunaga, Ryo Naito, Toru Kontani, Shin-ichi Tsukamoto, Toshiyasu Mase
Publikováno v:
Journal of medicinal chemistry. 40(8)
A series of N-[2-[(substituted chroman-8-yl)oxy]ethyl]-4-(4-methoxyphenyl)butylamines was prepared and examined for their 5-HT1A receptor antagonist activity. The parent compound 3a and seven analogs bearing five kinds of substituents on the chroman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0daae8f8238869a4337d9c6a5aa028
https://pubmed.ncbi.nlm.nih.gov/9111299
https://pubmed.ncbi.nlm.nih.gov/9111299
Publikováno v:
Journal of Organometallic Chemistry. 288:261-268
Secondary and/or tertiary alcohols and unsymmetrical ketones have been obtained in moderate to good yields by the palladium-catalyzed (5 mol%) carbonylative coupling of aryl iodides with alkylaluminum compounds under very mild conditions (20–50°C,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0774fa1176a8751bb85e986be454659
https://doi.org/10.1016/0022-328x(85)80118-2
https://doi.org/10.1016/0022-328x(85)80118-2