Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Tomoyuki Sumi"'
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63378 (2013)
Epiblast stem cells (EpiSCs) are primed pluripotent stem cells and can be derived from postimplantation mouse embryos. We now show that the absence of canonical Wnt/β-catenin signaling is essential for maintenance of the undifferentiated state in mo
Externí odkaz:
https://doaj.org/article/f3a47ac579164cb0ab112892f11d17e0
Autor:
Rie Tatsumi, Yutaka Suzuki Ph.D., Tomoyuki Sumi, Masakatsu Sone, Hirofumi Suemori, Norio Nakatsuji
Publikováno v:
Cell Transplantation, Vol 20 (2011)
Endothelial cells derived from human embryonic stem cells (hESC-ECs) hold much promise as a valuable tool for basic vascular research and for medical application such as cell transplantation or regenerative medicine. Here we have developed an efficie
Externí odkaz:
https://doaj.org/article/17112528bdd2416da642f98efa78241d
Autor:
Machiko Teramoto, Sayaka Satake, Tomoyuki Sumi, Yasuo Ishii, Hideaki Iida, Mai Fujii, Chikara Meno, Sachiko Inamori, Hisato Kondoh
Publikováno v:
Dev Growth Differ
Development, Growth & Differentiation
Development, Growth & Differentiation
Endoderm precursors expressing FoxA2 and Sox17 develop from the epiblast through the gastrulation process. In this study, we developed an experimental system to model the endoderm‐generating gastrulation process using epiblast stem cells (EpiSCs).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0425b5c4ccd69ff7023f37b78a23b5
https://pubmed.ncbi.nlm.nih.gov/33164208
https://pubmed.ncbi.nlm.nih.gov/33164208
Autor:
Norihiro Tsuneyoshi, Yogavalli Poobalan, Hirofumi Suemori, Tomoyuki Sumi, Ee Kim Tan, Norio Nakatsuji, N. Ray Dunn, Akila Sadasivam
Publikováno v:
Genes & Development. 26:2471-2476
Activin/Nodal signaling via SMAD2/3 maintains human embryonic stem cell (hESC) pluripotency by direct transcriptional regulation of NANOG or, alternatively, induces mesoderm and definitive endoderm (DE) formation. In search of an explanation for thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9e73a4e12e802083fb5ac2bbe3c484
https://doi.org/10.1101/gad.201772.112
https://doi.org/10.1101/gad.201772.112
Autor:
Tomoyuki Sumi, Kaori Yamauchi, Norio Nakatsuji, Tomomi G. Otsuji, Eihachiro Kawase, Hirofumi Suemori, Itsunari Minami
Publikováno v:
Genes to Cells. 15:1216-1227
Cardiomyocytes arise from cells that migrate to the mid-to-anterior region of the primitive streak (PS) during embryogenesis. We previously showed that canonical Wnt/β-catenin pathway signaling leads to the development of nascent PS populations from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ae75a788c89d2943ef9967388b09a2d
https://doi.org/10.1111/j.1365-2443.2010.01455.x
https://doi.org/10.1111/j.1365-2443.2010.01455.x
Publikováno v:
Development. 135:2969-2979
The canonical Wnt/beta-catenin signaling has remarkably diverse roles in embryonic development, stem cell self-renewal and cancer progression. Here, we show that stabilized expression of beta-catenin perturbed human embryonic stem (hES)-cell self-ren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde50db83f326600a89754669bf500fb
https://doi.org/10.1242/dev.021121
https://doi.org/10.1242/dev.021121
Autor:
Chikara Meno, Satomi Ikuta, Norio Wake, Keiko Kitajima, Tomoyuki Sumi, Masahiro Hachisuga, Kiyoko Kato, Shinya Oki
Publikováno v:
Proceedings of the National Academy of Sciences. 112
Congenital heart defects with heterotaxia are associated with pregestational diabetes mellitus. To provide insight into the mechanisms underlying such diabetes-related heart defects, we examined the effects of high-glucose concentrations on formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25213d39de5ad2887ad1f10f99ecca5f
https://doi.org/10.1073/pnas.1504529112
https://doi.org/10.1073/pnas.1504529112
Autor:
Hirofumi Suemori, Tomoyuki Sumi, Eihachiro Kawase, Norio Nakatsuji, Keiko Adachi, Kentaro Yasuchika
Publikováno v:
STEM CELLS. 24:2566-2572
Human embryonic stem cells (ESCs) would provide a potentially unlimited source for cell replacement therapies. However, the molecular mechanisms involved in the maintenance of "stemness" are not fully understood. Monkey ESCs are much more similar in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efbb80b5546e1fcee8a9a7194fbeed09
https://doi.org/10.1634/stemcells.2005-0659
https://doi.org/10.1634/stemcells.2005-0659
Autor:
Flavia Bollati, Adriana Ferreira, Mariano Bisbal, Toshikazu Nakamura, Santiago Quiroga, Tomoyuki Sumi, Alfredo Cáceres, Diego Peretti, Silvana B. Rosso
Publikováno v:
Molecular Biology of the Cell. 15:3433-3449
In this study, we examined the subcellular distribution and functions of LIMK1 in developing neurons. Confocal microscopy, subcellular fractionation, and expression of several epitope-tagged LIMK1 constructs revealed that LIMK1 is enriched in the Gol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b1369311d11064ea33055feeba5940
https://doi.org/10.1091/mbc.e03-05-0328
https://doi.org/10.1091/mbc.e03-05-0328
Publikováno v:
Biochemical and Biophysical Research Communications. 290:1315-1320
LIM-kinases (LIMK1 and LIMK2) regulate actin cytoskeletal reorganization through phosphorylation of cofilin, an actin-depolymerizing factor of actin filaments. Here, we describe a detailed analysis of the cell-cycle-dependent activity of endogenous L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27905a65aff839798491a9b64d3b510a
https://doi.org/10.1006/bbrc.2002.6346
https://doi.org/10.1006/bbrc.2002.6346