Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Tomoyuki Nishimoto"'
Autor:
Misato Nakanishi-Koakutsu, Kenji Miki, Yuki Naka, Masako Sasaki, Takayuki Wakimizu, Stephanie C. Napier, Chikako Okubo, Megumi Narita, Misato Nishikawa, Reo Hata, Kazuhisa Chonabayashi, Akitsu Hotta, Kenichi Imahashi, Tomoyuki Nishimoto, Yoshinori Yoshida
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Current differentiation protocols for human induced pluripotent stem cells (hiPSCs) produce heterogeneous cardiomyocytes (CMs). Although chamber-specific CM selection using cell surface antigens enhances biomedical applications, a cell surfa
Externí odkaz:
https://doaj.org/article/73e8538871d040e3ae7023f2f88a2a49
Autor:
Kenji Miki, Kohei Deguchi, Misato Nakanishi-Koakutsu, Antonio Lucena-Cacace, Shigeru Kondo, Yuya Fujiwara, Takeshi Hatani, Masako Sasaki, Yuki Naka, Chikako Okubo, Megumi Narita, Ikue Takei, Stephanie C. Napier, Tsukasa Sugo, Sachiko Imaichi, Taku Monjo, Tatsuya Ando, Norihisa Tamura, Kenichi Imahashi, Tomoyuki Nishimoto, Yoshinori Yoshida
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) suffer from limited maturation. Here the authors identify ERRγ agonist as a factor that enhances cardiac morphological, metabolic, contractile and electrical maturation
Externí odkaz:
https://doaj.org/article/e591e23480c3403b95a1cc6ecca9b455
Autor:
Tomoya Hara, Takeshi Yamamura, Mirei Murakami‐Asahina, Hirokazu Matsumoto, Michiyasu Takeyama, Ray Kanagawa, Tomoyuki Nishimoto
Publikováno v:
FEBS Open Bio, Vol 10, Iss 5, Pp 718-725 (2020)
Renin is the rate‐limiting enzyme of the renin–angiotensin system cascade, which drives the pathophysiological progression of heart failure. Species differences in the amino acid sequence of the catalytic domain of renin limit evaluations of the
Externí odkaz:
https://doaj.org/article/287bbc4b72704e4cac75bc2a86052101
Autor:
Masaki Kohno, Takatoshi Arakawa, Naoki Sunagawa, Tetsuya Mori, Kiyohiko Igarashi, Tomoyuki Nishimoto, Shinya Fushinobu
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0241912 (2020)
Cyclic α-maltosyl-(1→6)-maltose (CMM) is a cyclic glucotetrasaccharide with alternating α-1,4 and α-1,6 linkages. Here, we report functional and structural analyses on CMM-binding protein (CMMBP), which is a substrate-binding protein (SBP) of an
Externí odkaz:
https://doaj.org/article/6b468481e02e4c9dbbbec054feed9031
Autor:
Tomoya Hara, Satoshi Nishimura, Toshihiro Yamamoto, Yumiko Kajimoto, Keiji Kusumoto, Ray Kanagawa, Shota Ikeda, Tomoyuki Nishimoto
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202176 (2018)
The renin-angiotensin system (RAS), which plays an important role in the progression of heart failure, is efficiently blocked by the inhibition of renin, the rate-limiting enzyme in the RAS cascade. In the present study, we investigated the cardiopro
Externí odkaz:
https://doaj.org/article/9efef12b0fba49c798efdeb569f6bed4
Autor:
Shuji Nakamura, Toshio Kunikata, Yohsuke Matsumoto, Toshiharu Hanaya, Akira Harashima, Tomoyuki Nishimoto, Shimpei Ushio
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186640 (2017)
Cyclic nigerosyl nigerose (CNN) is a cyclic tetrasaccharide that exhibits properties distinct from other conventional cyclodextrins. Herein, we demonstrate that treatment of B16 melanoma with CNN results in a dose-dependent decrease in melanin synthe
Externí odkaz:
https://doaj.org/article/6c245a452a4946ccb08e2efa7b0b5b3e
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168486 (2016)
Sarcoplasmic reticulum Ca2+-ATPase 2a (SERCA2a) and its inhibitory protein called phospholamban (PLN) are pivotal for Ca2+ handling in cardiomyocyte and are known that their expression level and activity were changed in the heart failure patients. To
Externí odkaz:
https://doaj.org/article/68ce5e015df24b098938f0b5c0cbfdc1
Autor:
Kozo Hayashi, Ryo Yamashita, Ritsuko Takami, Toshikatsu Matsui, Masamitsu Gotou, Tomoyuki Nishimoto, Hiroyuki Kobayashi
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 4, Iss 4, p 17 (2017)
Protein function is mainly modulated by dynamic reversible or irreversible post-translational modifications. Among them, the identification of protein phosphorylation sites and changes in phosphorylation levels in vivo are of considerable interest fo
Externí odkaz:
https://doaj.org/article/e1ddc46fc99a4763bbafbb6bae0ff176
Autor:
Akihiro Fujita, Akira Kawashima, Yuuki Mitsukawa, Hiromi Ota, Noriaki Kitagawa, Takashi Suzuki, Yuji Noguchi, Shuichi Hirose, Hikaru Watanabe, Tetsuya Mori, Tomoyuki Nishimoto, Hajime Aga, Shimpei Ushio, Koryu Yamamoto
Publikováno v:
Bulletin of Applied Glycoscience. 12:92-98
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d26e68e30742735f7be6cc42a78c0d5
https://doi.org/10.5458/bag.12.2_92
https://doi.org/10.5458/bag.12.2_92
Autor:
Hajime Aga, Hikaru Watanabe, Shimpei Ushio, Tetsuya Mori, Noriaki Kitagawa, Koryu Yamamoto, Tomoyuki Nishimoto
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 85:2450-2458
We attempted to develop an efficient method for producing isomaltose, a disaccharide consisting of an α-(1→6)-linkage, from starch by combining enzymes of known activity. We found that the combination of 1,4-α-glucan 6-α-glucosyltransferase from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257c5d4e39fc6653e4839803f541987f
https://doi.org/10.1093/bbb/zbab173
https://doi.org/10.1093/bbb/zbab173