Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Tomoyuki Mashimo"'
Autor:
Xiaofei Gao, Zhaohuan Zhang, Tomoyuki Mashimo, Bo Shen, James Nyagilo, Hao Wang, Yihui Wang, Zhida Liu, Aditi Mulgaonkar, Xiao-Ling Hu, Sara G.M. Piccirillo, Ugur Eskiocak, Digant P. Davé, Song Qin, Yongjie Yang, Xiankai Sun, Yang-Xin Fu, Hui Zong, Wenzhi Sun, Robert M. Bachoo, Woo-ping Ge
Publikováno v:
Cell Reports, Vol 30, Iss 8, Pp 2489-2500.e5 (2020)
Summary: Emerging evidence suggests that crosstalk between glioma cells and the brain microenvironment may influence brain tumor growth. To date, known reciprocal interactions among these cells have been limited to the release of paracrine factors. C
Externí odkaz:
https://doaj.org/article/bbf1b45e59a14c7fa609bc4ef41b8bc0
Autor:
Dinesh K. Singh, Rahul K. Kollipara, Vamsidara Vemireddy, Xiao-Li Yang, Yuxiao Sun, Nanda Regmi, Stefan Klingler, Kimmo J. Hatanpaa, Jack Raisanen, Steve K. Cho, Shyam Sirasanagandla, Suraj Nannepaga, Sara Piccirillo, Tomoyuki Mashimo, Shan Wang, Caroline G. Humphries, Bruce Mickey, Elizabeth A. Maher, Hongwu Zheng, Ryung S. Kim, Ralf Kittler, Robert M. Bachoo
Publikováno v:
Cell Reports, Vol 18, Iss 4, Pp 961-976 (2017)
Efforts to identify and target glioblastoma (GBM) drivers have primarily focused on receptor tyrosine kinases (RTKs). Clinical benefits, however, have been elusive. Here, we identify an SRY-related box 2 (SOX2) transcriptional regulatory network that
Externí odkaz:
https://doaj.org/article/584c70e23319436aa0e06b23b2f7fe46
Autor:
Tou Yia Vue, Mark D. Borromeo, Jane E. Johnson, Tomoyuki Mashimo, Rahul K. Kollipara, Dennis K. Burns, Robert Bachoo, Tyler Smith
Publikováno v:
Glia
Glioblastomas (GBMs) are incurable brain tumors with a high degree of cellular heterogeneity and genetic mutations. Transcription factors that normally regulate neural progenitors and glial development are aberrantly coexpressed in GBM, conferring ca
Autor:
Kyriakos P. Papadopoulos, Amita Patnaik, Michael J. Wick, Tomoyuki Mashimo, Lizette Gamez, Drew W. Rasco, Alyssa Moriarty
Publikováno v:
Cancer Research. 80:P1-03
Background: Palbociclib is one of three CDK 4/6 inhibitors approved in combination with an aromatase inhibitor for treatment of hormone receptor-positive breast cancer. Although this combination therapy has been found effective in some patients, resi
Autor:
Ingrid Grummt, Sergey Mareninov, Holger Bierhoff, Paul S. Mischel, Hiroko Shimada, Lionel M.L. Chow, Nazanin Majd, Makoto Suematsu, Greg Lucey, Alexander Otto Eberhardt, Maya Asano, Yuki Ban, Kaori Kofuji, Eric P. Smith, Eric C. Holland, Noriaki Minami, Ralph J. DeBerardinis, Daisuke Yamashita, Ichiro Nakano, Kazutaka Sumita, Yoshiki Ikeda, Hirofumi Yoshino, Yuki Sugiura, Robert Bachoo, Lisa Lange, Akshiv Malhotra, Mika Sasaki, Risa Kawaguchi, Yonehiro Kanemura, Akiyoshi Hirayama, Annmarie Ramkissoon, William H. Yong, Masaru Mori, Trisha Wise-Draper, Tomoyoshi Soga, Dimitrios Anastasiou, Jumpei Terakawa, Juri Kiyokawa, Tatsuya Ozawa, Hiroaki Wakimoto, Kara Wolfe, Atsuo T. Sasaki, Nobuyuki Onishi, Satoshi Kofuji, Satsuki Ikeda, Craig Horbinski, Takiko Daikoku, Koichi Okumura, Mikako Warren, Shin Morioka, Hideyuki Saya, Naoya Sakamoto, Shuji Kitahara, Oltea Sampetrean, Wataru Yasui, Tomoyuki Mashimo, Victoria L. Flanary
Publikováno v:
Nature cell biology
In many cancers, high proliferation rates correlate with elevation of rRNA and tRNA levels, and nucleolar hypertrophy. However, the underlying mechanisms linking increased nucleolar transcription and tumorigenesis are only minimally understood. Here
Autor:
Robert Bachoo, Rahul K. Kollipara, Dennis K. Burns, Tyler Smith, Tou Yia Vue, Tomoyuki Mashimo, Jane E. Johnson, Mark D. Borromeo
Glioblastomas (GBMs) are incurable brain tumors with a high degree of cellular heterogeneity and genetic mutations. Transcription factors that normally regulate neural progenitors and glial development are aberrantly co-expressed in GBM, conferring c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5053c82d5eab8d60f10ea50c206615c4
https://doi.org/10.1101/2020.02.20.958132
https://doi.org/10.1101/2020.02.20.958132
Autor:
Keith Mcleod Hulsey, Edward Pan, Elizabeth A. Maher, Shanrong Zhang, Vamsidhara Vemireddy, Tomoyuki Mashimo, Bruce E. Mickey, Robin A. de Graaf, Vivek Tiwari, Toral R. Patel, Zhongxu An, Pegah Askari, Changho Choi, Sara Grazia Maria Piccirillo, Robert Bachoo
Publikováno v:
Magn Reson Med
Purpose To generate a preclinical model of isocitrate dehydrogenase (IDH) mutant gliomas from glioma patients and design a MRS method to test the compatibility of 2-hydroxyglutarate (2HG) production between the preclinical model and patients. Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04521b7d9d1ddc3636d8f4799763951
https://europepmc.org/articles/PMC7263951/
https://europepmc.org/articles/PMC7263951/
Autor:
Elizabeth A. Maher, David S. Baskin, Craig R. Malloy, Omkar B. Ijare, Isaac Marin-Valencia, Kumar Pichumani, Tomoyuki Mashimo, Vamsidhara Vemireddy, Robert Bachoo, Bruce E. Mickey
Publikováno v:
FEBS Letters. 591:3548-3554
Malignant brain tumors are known to utilize acetate as an alternate carbon source in the citric acid cycle for their bioenergetics. 13 C NMR-based isotopomer analysis has been used to measure turnover of 13 C-acetate carbons into glutamate and glutam
Autor:
Shyam Sirasanagandla, Robert Bachoo, Hongwu Zheng, Elizabeth A. Maher, Suraj Nannepaga, Nanda Regmi, Sara Grazia Maria Piccirillo, Steve K. Cho, Dinesh K. Singh, Ryung S. Kim, Stefan Klingler, Caroline G. Humphries, Xiao Li Yang, Bruce E. Mickey, Yuxiao Sun, Kimmo J. Hatanpaa, Vamsidara Vemireddy, Shan Wang, Jack M Raisanen, Tomoyuki Mashimo, Ralf Kittler, Rahul K. Kollipara
Publikováno v:
Cell Reports, Vol 18, Iss 4, Pp 961-976 (2017)
Efforts to identify and target glioblastoma (GBM) drivers have primarily focused on receptor tyrosine kinases (RTKs). Clinical benefits, however, have been elusive. Here, we identify a SRY-related box 2 (SOX2) transcriptional regulatory network that
Autor:
Tomoyuki Mashimo, James O Nyagilo, Hui Zong, Xiankai Sun, Yihui Wang, Wenzhi Sun, Xiao Ling Hu, Xiaofei Gao, Zhida Liu, Bo Shen, Song Qin, Zhaohuan Zhang, Yang Xin Fu, Aditi Mulgaonkar, Robert Bachoo, Hao Wang, Sara Grazia Maria Piccirillo, Ugur Eskiocak, Digant P. Davé, Yongjie Yang, Woo Ping Ge
Publikováno v:
Cell Reports, Vol 30, Iss 8, Pp 2489-2500.e5 (2020)
Summary: Emerging evidence suggests that crosstalk between glioma cells and the brain microenvironment may influence brain tumor growth. To date, known reciprocal interactions among these cells have been limited to the release of paracrine factors. C