Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Tomoyuki Mano"'
Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation
Autor:
Kazuhiro Kon, Koji L. Ode, Tomoyuki Mano, Hiroshi Fujishima, Riina R. Takahashi, Daisuke Tone, Chika Shimizu, Shinnosuke Shiono, Saori Yada, Kyoko Matsuzawa, Shota Y. Yoshida, Junko Yoshida Garçon, Mari Kaneko, Yuta Shinohara, Rikuhiro G. Yamada, Shoi Shi, Kazunari Miyamichi, Kenta Sumiyama, Hiroshi Kiyonari, Etsuo A. Susaki, Hiroki R. Ueda
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The homeostatic regulation of sleep is characterized by rebound sleep after prolonged wakefulness, but the molecular and cellular mechanisms underlying this regulation are still unknown. In this study, we show that Ca2+/calmodulin-dependent
Externí odkaz:
https://doaj.org/article/1820ed7e972241e4b90b7d9e83e720d1
Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing
Autor:
Shimpei I. Kubota, Kei Takahashi, Tomoyuki Mano, Katsuhiko Matsumoto, Takahiro Katsumata, Shoi Shi, Kazuki Tainaka, Hiroki R. Ueda, Shogo Ehata, Kohei Miyazono
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Shimpei Kubota et al. describe a pipeline for quantitative whole-organ analysis that that combines tissue clearing, 3D imaging, and machine learning for analysis of the tumour microenvironment. The authors apply this in a mouse model of lung tumour a
Externí odkaz:
https://doaj.org/article/b9b43d1be89a48cd9299b239e2a3ca11
Autor:
Tomoyuki Mano, Ken Murata, Kazuhiro Kon, Chika Shimizu, Hiroaki Ono, Shoi Shi, Rikuhiro G. Yamada, Kazunari Miyamichi, Etsuo A. Susaki, Kazushige Touhara, Hiroki R. Ueda
Publikováno v:
Cell Reports: Methods, Vol 1, Iss 2, Pp 100038- (2021)
Summary: Recent advancements in tissue clearing technologies have offered unparalleled opportunities for researchers to explore the whole mouse brain at cellular resolution. With the expansion of this experimental technique, however, a scalable and e
Externí odkaz:
https://doaj.org/article/1201485fe4114ae4957735926d3fa8ad
Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation
Autor:
Kazuhiro Kon, Koji L. Ode, Tomoyuki Mano, Hiroshi Fujishima, Daisuke Tone, Chika Shimizu, Shinnosuke Shiono, Saori Yada, Junko Yoshida Garçon, Mari Kaneko, Yuta Shinohara, Riina R. Takahashi, Rikuhiro G. Yamada, Shoi Shi, Kenta Sumiyama, Hiroshi Kiyonari, Etsuo A. Susaki, Hiroki R. Ueda
The homeostatic regulation of sleep is characterized by rebound sleep after prolonged wakefulness, but the molecular and cellular mechanisms underlying this regulation are still unknown. We show here that CaMKII-dependent activity control of parvalbu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea5bd4b9d9ddb6494fa3545ae2cac0df
https://doi.org/10.1101/2023.04.29.537929
https://doi.org/10.1101/2023.04.29.537929
Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing
Autor:
Kei Takahashi, Kazuki Tainaka, Tomoyuki Mano, Shogo Ehata, Hiroki R. Ueda, Kohei Miyazono, Shimpei I. Kubota, Takahiro Katsumata, Shoi Shi, Katsuhiko Matsumoto
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications Biology
Communications Biology
Tissue clearing is one of the most powerful strategies for a comprehensive analysis of disease progression. Here, we established an integrated pipeline that combines tissue clearing, 3D imaging, and machine learning and applied to a mouse tumour mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f29edb7da682011b51ef5b4f65fda0
https://doaj.org/article/b9b43d1be89a48cd9299b239e2a3ca11
https://doaj.org/article/b9b43d1be89a48cd9299b239e2a3ca11
Autor:
Tomonobu M. Watanabe, Hirokazu Hirai, Tatsuya C. Murakami, Junichi Kaneshiro, Hiroshi Fujishima, Tomoki T Mitani, Shuhei A. Horiguchi, Ayumu Konno, Katsuhiko Matsumoto, Tomoyuki Mano, Hiroki R. Ueda
Publikováno v:
Nature Protocols. 14:3506-3537
Tissue-clearing techniques are powerful tools for biological research and pathological diagnosis. Here, we describe advanced clear, unobstructed brain imaging cocktails and computational analysis (CUBIC) procedures that can be applied to biomedical r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9a2d2172fbe4cd56f1f94f456d5240d
https://doi.org/10.1038/s41596-019-0240-9
https://doi.org/10.1038/s41596-019-0240-9
Autor:
Shoi Shi, Rikuhiro G. Yamada, Kazunari Miyamichi, Chika Shimizu, Hiroki R. Ueda, Kazuhiro Kon, Etsuo A. Susaki, Tomoyuki Mano, Ken Murata, Hiroaki Ono, Kazushige Touhara
Recent advancements in tissue clearing technologies have offered unparalleled opportunities for researchers to explore the whole mouse brain at cellular resolution. With the expansion of this experimental technique, however, a scalable and easy-to-us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5a9f8789ec98a63c950ed955b63ebc8
https://doi.org/10.1101/2020.08.28.271031
https://doi.org/10.1101/2020.08.28.271031
Autor:
Katsuhiko, Matsumoto, Tomoki T, Mitani, Shuhei A, Horiguchi, Junichi, Kaneshiro, Tatsuya C, Murakami, Tomoyuki, Mano, Hiroshi, Fujishima, Ayumu, Konno, Tomonobu M, Watanabe, Hirokazu, Hirai, Hiroki R, Ueda
Publikováno v:
Nature protocols. 14(12)
Tissue-clearing techniques are powerful tools for biological research and pathological diagnosis. Here, we describe advanced clear, unobstructed brain imaging cocktails and computational analysis (CUBIC) procedures that can be applied to biomedical r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::50758e0d1ff2bfb6a5876c3501e4db95
https://pubmed.ncbi.nlm.nih.gov/31748753
https://pubmed.ncbi.nlm.nih.gov/31748753
Autor:
Hiroki R. Ueda, Jennifer B. Treweek, Kwanghun Chung, Hans-Ulrich Dodt, Atsushi Miyawaki, Ali Ertürk, Viviana Gradinaru, Tomoyuki Mano, Alexandre Albanese
In this photo essay, we present a sampling of technologies from laboratories at the forefront of whole-brain clearing and imaging for high-resolution analysis of cell populations and neuronal circuits. The data presented here were provided for the ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4532e6673fded91e6986c6f8b22e88a
https://resolver.caltech.edu/CaltechAUTHORS:20181105-084438080
https://resolver.caltech.edu/CaltechAUTHORS:20181105-084438080
Autor:
Tatsuya C, Murakami, Tomoyuki, Mano, Shu, Saikawa, Shuhei A, Horiguchi, Daichi, Shigeta, Kousuke, Baba, Hiroshi, Sekiya, Yoshihiro, Shimizu, Kenji F, Tanaka, Hiroshi, Kiyonari, Masamitsu, Iino, Hideki, Mochizuki, Kazuki, Tainaka, Hiroki R, Ueda
Publikováno v:
Nature neuroscience. 21(4)
A three-dimensional single-cell-resolution mammalian brain atlas will accelerate systems-level identification and analysis of cellular circuits underlying various brain functions. However, its construction requires efficient subcellular-resolution im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::552ca444c50b712d3a25c0ee3f8467d4
https://pubmed.ncbi.nlm.nih.gov/29507408
https://pubmed.ncbi.nlm.nih.gov/29507408