Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Tomoyuki Kawachi"'
Publikováno v:
Xenobiotica. 51:287-296
The human mass balance of lusutrombopag, an orally bioavailable thrombopoietin (TPO) receptor agonist, was characterised in seven healthy male subjects after a single oral dose of [14C]-lusutrombop...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a724d3cdfb02fe222415abc0fb2f604
https://doi.org/10.1080/00498254.2020.1845416
https://doi.org/10.1080/00498254.2020.1845416
Autor:
Motohiro Fujiu, Tomoyuki Kawachi, Jun Sato, Kazuo Komano, Satoshi Miyagawa, Katsuki Yokoo, Satoru Shibuya, Kenji Yamawaki, Soichiro Sato, Hiroki Kusano, Naoki Kohira, Toshiaki Aoki
Publikováno v:
ACS Infectious Diseases. 6:3034-3047
By the emergence and worldwide spread of multi-drug-resistant Gram-negative bacteria, there have been growing demands for efficacious drugs to cure these resistant infections. The key mechanism for resistance to β-lactam antibiotics is the productio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226f2e73d66c070577aed0a202c4d2ee
https://doi.org/10.1021/acsinfecdis.0c00560
https://doi.org/10.1021/acsinfecdis.0c00560
Autor:
Hideki Maki, Kenji Yamawaki, Toshiaki Aoki, Daiki Nagamatsu, Ryosuke Watari, Motohiro Fujiu, Hiroki Kusano, Yuya Hirakawa, Kazuo Komano, Sachi Kanazawa, Emi Kashiwagi, Naoki Kohira, Satoru Shibuya, Soichiro Sato, Tomoyuki Kawachi, Jun Sato, Katsuki Yokoo
Publikováno v:
Journal of medicinal chemistry. 64(13)
Coadministration of β-lactam and β-lactamase inhibitor (BLI) is one of the well-established therapeutic measures for bacterial infections caused by β-lactam-resistant Gram-negative bacteria, whereas we have only two options for orally active BLI,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d801b14baef775748dd591c64248fd92
https://pubmed.ncbi.nlm.nih.gov/34143627
https://pubmed.ncbi.nlm.nih.gov/34143627
Autor:
Yasuyoshi Iso, Shigeru Ando, Harrie J.M. Gijsen, Yasuto Kido, Shinji Suzuki, Herman Borghys, Kenji Morimoto, Vijay Urmaliya, Deborah Dhuyvetter, Takahiko Yamamoto, Ard Teisman, Gaku Sakaguchi, Naoki Kanegawa, Nigel Austin, Eriko Matsuoka, An Van Den Bergh, Hisanori Ito, Takuya Oguma, Francois Paul Bischoff, Tamio Fukushima, Peter Verboven, Tomoyuki Kawachi, Kenji Nakahara, Yoshinori Yamano, Kosuke Anan, Ken-ichi Kusakabe
Publikováno v:
ChemMedChem. 14:1894-1910
The β-site amyloid precursor protein cleaving enzyme 1 (BACE1, also known as β-secretase) is a promising target for the treatment of Alzheimer's disease. A pKa lowering approach over the initial leads was adopted to mitigate hERG inhibition and P-g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985639c1cf0555b69c371d024a0d30ea
https://doi.org/10.1002/cmdc.201900478
https://doi.org/10.1002/cmdc.201900478
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Drug absorption via the intestinal tissue is modulated by membrane permeability and metabolism in intestinal epithelial cells (IECs). In drug discovery research, using human IECs to evaluate membrane permeability and metabolic stability can offer ver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c88bb325467289f9451ec51115ed9d5a
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100835585
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100835585
Autor:
Motohiro Fujiu, Katsuki Yokoo, Jun Sato, Satoru Shibuya, Kazuo Komano, Hiroki Kusano, Soichiro Sato, Toshiaki Aoki, Naoki Kohira, Satoshi Miyagawa, Tomoyuki Kawachi, Kenji Yamawaki
Publikováno v:
ACS Infectious Diseases; 11/13/2020, Vol. 6 Issue 11, p3034-3047, 14p
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 77:205-207
Im-3 was isolated from the venom of the scorpion Isometrus maculatus through several steps of HPLC fractionation based on the insect paralytic activity. Injecting Im-3 into crickets induced paralysis, but no toxicity was apparent in mice after an int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a723b4d2da22e2c0df0c86672486d77
https://doi.org/10.1271/bbb.120697
https://doi.org/10.1271/bbb.120697
Publikováno v:
Bioscience, biotechnology, and biochemistry. 76(11)
Scorpion venom is composed of a number of peptides, many of which show neurotoxicity. The Isometrus maculatus scorpion, belonging to the Buthidae family, is found in many tropical regions, including the southern islands of Japan, but there have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0999125bef48d06a260acc8c1dac86ce
https://pubmed.ncbi.nlm.nih.gov/23132570
https://pubmed.ncbi.nlm.nih.gov/23132570