Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Tomoyuki, Yamanaka"'
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 41, Iss , Pp 101165- (2024)
The SLC25A20 gene encodes carnitine-acylcarnitine translocase (CACT), facilitating the transport of long-chain acylcarnitine required for energy production via β-oxidation into the mitochondria. Loss-of-function mutations in this gene lead to CACT d
Externí odkaz:
https://doaj.org/article/d8a1a34b4db045d497cb085f1306aaee
Autor:
Hongsun Park, Tomoyuki Yamanaka, Yumiko Toyama, Atsushi Fujita, Hiroshi Doi, Takashi Nirasawa, Shigeo Murayama, Naomichi Matsumoto, Tomomi Shimogori, Masaya Ikegawa, Matti J. Haltia, Nobuyuki Nukina
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disorder, characterized by the presence of eosinophilic inclusions (NIIs) within nuclei of central and peripheral nervous system cells. This study aims to identify the com
Externí odkaz:
https://doaj.org/article/4f2888696a714b0ab7668db027d5f15c
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Intrinsically disordered proteins (IDPs) have been in the spotlight for their unique properties, such as their lack of secondary structures and low sequence complexity. Alpha-synuclein and tau are representative disease-related IDPs with low
Externí odkaz:
https://doaj.org/article/9b7e6292e9604b88b8dbf505351f982c
Autor:
Tomoyuki Yamanaka, Haruko Miyazaki, Asako Tosaki, Sankar N. Maity, Tomomi Shimogori, Nobutaka Hattori, Nobuyuki Nukina
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract A heterotrimeric transcription factor NF-Y is crucial for cell-cycle progression in various types of cells. In contrast, studies using NF-YA knockout mice have unveiled its essential role in endoplasmic reticulum (ER) homeostasis in neuronal
Externí odkaz:
https://doaj.org/article/ccbc7ee531b049c7937f687cdc397d5f
Publikováno v:
Contact, Vol 4 (2021)
Nearly twenty years ago a mutation in the VAPB gene, resulting in a proline to serine substitution (p.P56S), was identified as the cause of a rare, slowly progressing, familial form of the motor neuron degenerative disease Amyotrophic Lateral Scleros
Externí odkaz:
https://doaj.org/article/e6ab3001af5f4618909d3e3b99ea4ea8
Autor:
Ayami Okuzumi, Masaru Kurosawa, Taku Hatano, Masashi Takanashi, Shuuko Nojiri, Takeshi Fukuhara, Tomoyuki Yamanaka, Haruko Miyazaki, Saki Yoshinaga, Yoshiaki Furukawa, Tomomi Shimogori, Nobutaka Hattori, Nobuyuki Nukina
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-15 (2018)
Abstract Accumulating evidence suggests that the lesions of Parkinson’s disease (PD) expand due to transneuronal spreading of fibrils composed of misfolded alpha-synuclein (a-syn), over the course of 5–10 years. However, the precise mechanisms an
Externí odkaz:
https://doaj.org/article/50c83c6a542649af85a76996a77e9185
Autor:
Tomoyuki Yamanaka1,2,3,4 toyamana@bri.niigata-u.ac.jp, Masaru Kurosawa4, Aya Yoshida3, Tomomi Shimogori3, Akiko Hiyama2, Sankar N. Maity5, Nobutaka Hattori6, Hideaki Matsui1, Nobuyuki Nukina2,3,4 nnukina@mail.doshisha.ac.jp
Publikováno v:
Journal of Biological Chemistry. Feb2024, Vol. 300 Issue 2, p1-15. 15p.
Autor:
Tomoyuki Yamanaka, Nobuyuki Nukina
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
The endoplasmic reticulum (ER) is a morphologically dynamic organelle containing different membrane subdomains with distinct cellular functions. Numerous observations have revealed that ER stress response induced by disturbed ER homeostasis is linked
Externí odkaz:
https://doaj.org/article/777a41b5ad5b48889c7c76710f151844
Autor:
Tomoyuki Yamanaka, Akiko Hiyama, Yukio Imamura, Nobuyuki Nukina, Haruko Miyazaki, Junya Kasahara
Publikováno v:
Neuroscience Research. 170:341-349
The pathological form of a-synuclein (a-syn) is transmitted through neural circuits in the brains of Parkinson disease (PD) patients and amplifies misfolded a-syn, further forming intracellular deposits. However, the details of a-syn pre-formed fibri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db56cb18f863631357afc5aa3aa6d7b
https://doi.org/10.1016/j.neures.2020.11.009
https://doi.org/10.1016/j.neures.2020.11.009
Autor:
Hideaki Matsui, Shinji Ito, Hideki Matsui, Junko Ito, Gabdulkhaev, Ramil, Mika Hirose, Tomoyuki Yamanaka, Akihide Koyama, Taisuke Kato, Maiko Tanaka, Norihito Uemura, Noriko Matsui, Sachiko Hirokawa, Maki Yoshihama, Aki Shimozawa, Shin-ichiro Kubo, Kenji Iwasaki, Masato Hasegawa, Ryosuke Takahashi, Keisuke Hirai
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 6/6/2023, Vol. 120 Issue 23, p1-8, 44p