Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Tomoyo Ukai"'
Autor:
Jumpei Taguchi, Hirofumi Shibata, Mio Kabata, Masaki Kato, Kei Fukuda, Akito Tanaka, Sho Ohta, Tomoyo Ukai, Kanae Mitsunaga, Yosuke Yamada, So I Nagaoka, Sho Yamazawa, Kotaro Ohnishi, Knut Woltjen, Tetsuo Ushiku, Manabu Ozawa, Mitinori Saitou, Yoichi Shinkai, Takuya Yamamoto, Yasuhiro Yamada
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The mechanisms by which in vivo expression of the Yamanaka transcription factors (OSKM) renders somatic cells permissive for differentiation remain unclear. Here, the authors show that in vivo reprogramming using OSKM generates germ cell tumors and d
Externí odkaz:
https://doaj.org/article/ce67fa07507345ab98bca02b31126aed
Autor:
Manami SENOO, Hiroshi HOZOJI, Yu ISHIKAWA-YAMAUCHI, Takashi TAKIJIRI, Sho OHTA, Tomoyo UKAI, Mio KABATA, Takuya YAMAMOTO, Yasuhiro YAMADA, Masahito IKAWA, Manabu OZAWA
Publikováno v:
The Journal of Reproduction and Development, Vol 66, Iss 5, Pp 459-467 (2020)
PTBP1, a well-conserved RNA-binding protein, regulates cellular development by tuning posttranscriptional mRNA modification such as alternative splicing (AS) or mRNA stabilization. We previously revealed that the loss of Ptbp1 in spermatogonia causes
Externí odkaz:
https://doaj.org/article/b663433465594b679f115f4d9a3ebd35
Autor:
Masaki Yagi, Mio Kabata, Akito Tanaka, Tomoyo Ukai, Sho Ohta, Kazuhiko Nakabayashi, Masahito Shimizu, Kenichiro Hata, Alexander Meissner, Takuya Yamamoto, Yasuhiro Yamada
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
De novo DNA methylation is carried out by DNMT3A and DNMT3B, but the distinct functions of these two enzymes is poorly understood. Here the authors present a comprehensive, genome-wide identification of target sites for de novo DNA methylation by the
Externí odkaz:
https://doaj.org/article/b65b6e33e3a14ce7b532093c4f2b9276
Autor:
Shingo Komura, Kenji Ito, Sho Ohta, Tomoyo Ukai, Mio Kabata, Fumiaki Itakura, Katsunori Semi, Yutaka Matsuda, Kyoichi Hashimoto, Hirofumi Shibata, Masamitsu Sone, Norihide Jo, Kazuya Sekiguchi, Takatoshi Ohno, Haruhiko Akiyama, Katsuji Shimizu, Knut Woltjen, Manabu Ozawa, Junya Toguchida, Takuya Yamamoto, Yasuhiro Yamada
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
The EWS-ATF1 fusion gene causes clear cell sarcoma (CCS). Here, the authors show that the downstream effects of EWS-ATF1 expression are strictly context dependent, and reveal the cell of origin for CCS to be Tppp3-expressing cells in peripheral nerve
Externí odkaz:
https://doaj.org/article/d6a0a59accc9488fa4d118ffc7d1f1f9
Autor:
Masaki Yagi, Mio Kabata, Tomoyo Ukai, Sho Ohta, Akito Tanaka, Yui Shimada, Michihiko Sugimoto, Kimi Araki, Keisuke Okita, Knut Woltjen, Konrad Hochedlinger, Takuya Yamamoto, Yasuhiro Yamada
Publikováno v:
Stem Cell Reports, Vol 12, Iss 5, Pp 1113-1128 (2019)
Summary: CpG islands (CGIs) including those at imprinting control regions (ICRs) are protected from de novo methylation in somatic cells. However, many cancers often exhibit CGI hypermethylation, implying that the machinery is impaired in cancer cell
Externí odkaz:
https://doaj.org/article/16df7a08bde34afb9cf8bc2e9b4162c2
Autor:
Hirofumi Shibata, Shingo Komura, Yosuke Yamada, Nao Sankoda, Akito Tanaka, Tomoyo Ukai, Mio Kabata, Satoko Sakurai, Bunya Kuze, Knut Woltjen, Hironori Haga, Yatsuji Ito, Yoshiya Kawaguchi, Takuya Yamamoto, Yasuhiro Yamada
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Cellular reprogramming and cancer development share properties. Here, the authors examine the impact of in vivo reprogramming on Kras-induced cancer and show reprogramming-mediated repression of somatic cell enhancers in conjunction with Kras mutatio
Externí odkaz:
https://doaj.org/article/e71dfb2ea18648a280e7955320885433
Autor:
Yukinori Terada, Norihide Jo, Yoshiki Arakawa, Megumi Sakakura, Yosuke Yamada, Tomoyo Ukai, Mio Kabata, Kanae Mitsunaga, Yohei Mineharu, Sho Ohta, Masato Nakagawa, Susumu Miyamoto, Takuya Yamamoto, Yasuhiro Yamada
Publikováno v:
Cell Reports, Vol 26, Iss 10, Pp 2608-2621.e6 (2019)
Summary: Atypical teratoid/rhabdoid tumor (AT/RT), which harbors SMARCB1 mutation and exhibits a characteristic histology of rhabdoid cells, has a poor prognosis because of the lack of effective treatments. Here, we establish human SMARCB1-deficient
Externí odkaz:
https://doaj.org/article/a21290f37a8448f6882ad39ced9eab91
Autor:
Yui Shimada-Takayama, Takayuki Yasuda, Tomoyo Ukai, Jumpei Taguchi, Manabu Ozawa, Nao Sankoda, Sho Ohta, Yasuhiro Yamada
Publikováno v:
Biochemical and Biophysical Research Communications. 599:43-50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bba1d5ce24a72a58cb25380137a2b12e
https://doi.org/10.1016/j.bbrc.2022.02.005
https://doi.org/10.1016/j.bbrc.2022.02.005
Autor:
Michitada Hirano, Yusei So, Shin Tsunekawa, Mio Kabata, Sho Ohta, Hiroshi Sagara, Nao Sankoda, Jumpei Taguchi, Yosuke Yamada, Tomoyo Ukai, Makoto Kato, Jiro Nakamura, Manabu Ozawa, Takuya Yamamoto, Yasuhiro Yamada
Publikováno v:
Nature Metabolism. 4:254-268
β cells have a limited capacity for regeneration, which predisposes towards diabetes. Here, we show that, of the MYC family members, Mycl plays a key role in proliferation of pancreatic endocrine cells. Genetic ablation of Mycl causes a reduction in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac817dbb1660b2932d3b63eb45e0ed0
https://doi.org/10.1038/s42255-022-00530-y
https://doi.org/10.1038/s42255-022-00530-y
Autor:
Takashi Takijiri, Yu Ishikawa-Yamauchi, Hiroshi Hozoji, Manabu Ozawa, Tomoyo Ukai, Takuya Yamamoto, Manami Senoo, Masahito Ikawa, Sho Ohta, Mio Kabata, Yasuhiro Yamada
Publikováno v:
The Journal of Reproduction and Development
Manami SENOO, Hiroshi HOZOJI, Yu ISHIKAWA-YAMAUCHI, Takashi TAKIJIRI, Sho OHTA, Tomoyo UKAI, Mio KABATA, Takuya YAMAMOTO, Yasuhiro YAMADA, Masahito IKAWA, Manabu OZAWA, RNA-binding protein Ptbp1 regulates alternative splicing and transcriptome in spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb8a205cad2dab47ba9b134c6669a7a
https://doi.org/10.1262/jrd.2020-060
https://doi.org/10.1262/jrd.2020-060