Výsledky vyhledávání - "Tomoyo Sakata-Kato"

Akademický článek

A broad analysis of resistance development in the malaria parasite

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)

It is unclear whether new antimalarial compounds may rapidly lose effectiveness in the field because of parasite resistance. Here, Corey et al.investigate the acquisition of drug resistance and the extent to which common resistance mechanisms decreas

Externí odkaz: https://doaj.org/article/ce1be14e28304ebdb5d80a44a4d4e3b4

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Orthosteric–allosteric dual inhibitors of PfHT1 as selective antimalarial agents

Autor: Yu Xiao, Zhuoyi Liu, Xin Jiang, Tuan Zhang, Yafei Yuan, Debing Pu, Tomoyo Sakata-Kato, Na Zhao, Qingxuan Tang, Shuchen Luo, Hang Yin, Nieng Yan, Shuo Zhang, Nobutaka Kato, Jian Huang, Xikang Yang, Nan Wang

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance There is an urgent need for alternative antimalarials with the emergence of artemisinin-resistant malaria parasites. Blocking sugar uptake in Plasmodium falciparum by selectively inhibiting the hexose transporter P. falciparum hexose tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23cec0d0f919c4105c99167b0f207b57
http://europepmc.org/articles/PMC7826358

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Orthosteric-allosteric dual inhibitors of PfHT1 as selective anti-malarial agents

Autor: Hang Yin, Jian Huang, Shuo Zhang, Xin Jiang, Nieng Yan, Tuan Zhang, Tomoyo Sakata-Kato, Na Zhao, Nan Wang, Yu Xiao, Zhuoyi Liu, Nobutaka Kato, Qingxuan Tang, Xikang Yang, Yafei Yuan, Debing Pu, Shuchen Luo

Artemisinin-resistant malaria parasites have emerged and been spreading, posing a significant public health challenge. Anti-malarial drugs with novel mechanisms of action are therefore urgently needed. In this report, we exploit a “selective starva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad3d7af92293453386beebfd73dc62ff
https://doi.org/10.1101/2020.08.25.260232

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Bicyclic imidazolium inhibitors of Gli transcription factor activity

Autor: Marisa E. Hom, James K. Chen, Alison E. Ondrus, Tomoyo Sakata-Kato, Paul G. Rack

Publikováno v: ChemMedChem

Gli transcription factors within the Hedgehog (Hh) signaling pathway direct key events in mammalian development and promote a number of human cancers. Current therapies for Gli-driven tumors target Smoothened (SMO), a G protein-coupled receptor-like

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2c7d600154f819a2f15736942790e2
https://europepmc.org/articles/PMC7311267/

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In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model

Autor: Delfina C. Segura, Sabine Ottilie, Dyann F. Wirth, Alba Pablos-Tanarro, Sara Viera, Rebecca E. K. Mandt, Noemi Magan, Tomoyo Sakata-Kato, Maria Jose Lafuente-Monasterio, Madeline R. Luth, Amanda K. Lukens, Francisco-Javier Gamo, Elizabeth A. Winzeler

Publikováno v: Sci Transl Med

Resistance has developed in Plasmodium malaria parasites to every antimalarial drug in clinical use, prompting the need to characterize the pathways mediating resistance. Here, we report a framework for assessing development of resistance of Plasmodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127d5ee96687431f2ec7206e966055e9
https://doi.org/10.1126/scitranslmed.aav1636

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Conformation-guided analogue design identifies potential antimalarial compounds through inhibition of mitochondrial respiration

Autor: Tomoyo Sakata-Kato, Erik M. Larsen, Dyann F. Wirth, Joseph W. Arico, Chia-Fu Chang, Richard E. Taylor, Vince M Lombardo

Publikováno v: Org Biomol Chem

The synthesis of a 2-methyl-substituted analogue of the natural product, neopeltolide, is reported in an effort to analyze the importance of molecular conformation and ligand-target interactions in relation to biological activity. The methyl substitu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6830c3605f0ffcb686d546953be226db
https://doi.org/10.1039/c8ob01257a

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Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

Publikováno v: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Science (New York, N.Y.), vol 362, iss 6419
Science (New York, N.y.)

To discover leads for next-generation chemoprotective antimalarial drugs,we tested more than 500,000 compounds for their ability to inhibit liver-stage development of luciferase-expressing Plasmodium spp. parasites (681 compounds showed a half-maxima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276ca79aa5124b1a30513b1776aa4ace
https://doi.org/10.1126/science.aat9446

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A Novel Methodology for Bioenergetic Analysis of Plasmodium falciparum Reveals a Glucose-Regulated Metabolic Shift and Enables Mode of Action Analyses of Mitochondrial Inhibitors

Autor: Dyann F. Wirth, Tomoyo Sakata-Kato

Publikováno v: ACS Infectious Diseases. 2:903-916

Given that resistance to all drugs in clinical use has arisen, discovery of new antimalarial drug targets is eagerly anticipated. The Plasmodium mitochondrion has been considered a promising drug target largely based on its significant divergence fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc035d30358da72760c3405e3e6cebd
https://doi.org/10.1021/acsinfecdis.6b00101

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