Výsledky vyhledávání - "Tomoya Sasahara"

Akademický článek

High-throughput screening for agonists of ROS production in live human vascular endothelial cells

Publikováno v: STAR Protocols, Vol 3, Iss 1, Pp 101053- (2022)

Summary: Reactive oxygen species (ROS) are important physiological molecules, and identifying agonists for ROS production can yield useful tools for future research. Here we present an optimized protocol for high-throughput screening for agonists tha

Externí odkaz: https://doaj.org/article/5e18333ee58f4342a7c23d7cda6b1f35

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Akademický článek

Alzheimer's Aβ assembly binds sodium pump and blocks endothelial NOS activity via ROS-PKC pathway in brain vascular endothelial cells

Autor: Tomoya Sasahara, Kaori Satomura, Mari Tada, Akiyoshi Kakita, Minako Hoshi

Publikováno v: iScience, Vol 24, Iss 9, Pp 102936- (2021)

Summary: Amyloid β-protein (Aβ) may contribute to worsening of Alzheimer’s disease (AD) through vascular dysfunction, but the molecular mechanism involved is unknown. Using ex vivo blood vessels and primary endothelial cells from human brain micr

Externí odkaz: https://doaj.org/article/af27250a17cf40ab8398d6cd915da463

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Akademický článek

Alzheimer Aβ Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAKα3 Neurons by Secretion

Autor: Hitomi Komura, Shota Kakio, Tomoya Sasahara, Yoshie Arai, Naomi Takino, Michio Sato, Kaori Satomura, Takayuki Ohnishi, Yo-ichi Nabeshima, Shin-ichi Muramatsu, Isao Kii, Minako Hoshi

Publikováno v: iScience, Vol 13, Iss , Pp 452-477 (2019)

Summary: We identified ∼30-mer amyloid-β protein (Aβ) assemblies, termed amylospheroids, from brains of patients with Alzheimer disease (AD) as toxic entities responsible for neurodegeneration and showed that Na+,K+-ATPase α3 (NAKα3) is the sol

Externí odkaz: https://doaj.org/article/060255313e404577b2ed41099ebafc92

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Alzheimer Aβ Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAKα3 Neurons by Secretion

Autor: Yoshie Arai, Tomoya Sasahara, Naomi Takino, Takayuki Ohnishi, Shota Kakio, Isao Kii, Michio Sato, Shin-ichi Muramatsu, Kaori Satomura, Hitomi Komura, Minako Hoshi, Yo-ichi Nabeshima

Publikováno v: iScience
iScience, Vol 13, Iss, Pp 452-477 (2019)

Summary We identified ∼30-mer amyloid-β protein (Aβ) assemblies, termed amylospheroids, from brains of patients with Alzheimer disease (AD) as toxic entities responsible for neurodegeneration and showed that Na+,K+-ATPase α3 (NAKα3) is the sole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03027edcc89e936a5743b3a627919567
https://doi.org/10.1016/j.isci.2019.01.018

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Alzheimer’s Aβ assembly binds sodium pump and blocks endothelial NOS activity via ROS-PKC pathway

Autor: Minako Hoshi, Akiyoshi Kakita, Kaori Satomura, Tomoya Sasahara, Mari Tada

Amyloid β-protein (Aβ) may contribute to worsening of Alzheimer’s disease (AD) through vascular dysfunction, but the actual molecular mechanisms remain controversial. Using ex-vivo blood vessels and primary endothelial cells derived from human br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::238db31f281ed0c5f828aaad9c880c7f
https://doi.org/10.1101/2020.12.10.419879

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High-throughput screening for agonists of ROS production in live human vascular endothelial cells

Autor: Tomoya, Sasahara, Minako, Hoshi

Publikováno v: STAR Protocols, Vol 3, Iss 1, Pp 101053-(2022)
STAR Protocols

Summary Reactive oxygen species (ROS) are important physiological molecules, and identifying agonists for ROS production can yield useful tools for future research. Here we present an optimized protocol for high-throughput screening for agonists that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32dc16261361ae80aa37fe5b6556f6d
https://doi.org/10.1254/jpssuppl.96.0_1-b-p-018

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NMR-based site-resolved profiling of β-amyloid misfolding reveals structural transitions from pathologically relevant spherical oligomer to fibril

Autor: Yoshitaka Ishii, Minako Hoshi, Isamu Matsuda, Yiling Xiao, Masafumi Inoue, Tomoya Sasahara

Publikováno v: J Biol Chem

Increasing evidence highlights the central role of neurotoxic oligomers of the 42-residue-long β-amyloid (Aβ42) in Alzheimer's disease (AD). However, very limited information is available on the structural transition from oligomer to fibril, partic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::516870491858f9a8b150e302a9271b52
https://pubmed.ncbi.nlm.nih.gov/31771980

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Epidermal Growth Factor Enhances Orthovanadate-Induced Contraction via Src and Myosin Phosphatase Target Subunit 1 in Rat Vascular Smooth Muscle

Autor: Mariko Shin, Katsutoshi Yayama, Tomoya Sasahara, Natsumi Ohkura, Akira Onodera

Publikováno v: Pharmacology & Pharmacy. :329-340

Inhibition of protein tyrosine phosphatase by orthovanadate induces vasoconstriction, which is mediated by the Rho kinase-dependent inactivation of myosin light chain phosphatase (MLCP) via signaling downstream of Src-induced activation of the epider

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::239076f59b9d278f63286133abe99ed0
https://doi.org/10.4236/pp.2015.67035

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