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Akademický článek

FK614, a Novel Peroxisome Proliferator-Activated Receptor γ Modulator, Induces Differential Transactivation Through a Unique Ligand-Specific Interaction With Transcriptional Coactivators

Autor: Takao Fujimura, Hiroyuki Sakuma, Satoko Konishi, Tomoya Oe, Naomi Hosogai, Chiaki Kimura, Ichiro Aramori, Seitaro Mutoh

Publikováno v: Journal of Pharmacological Sciences, Vol 99, Iss 4, Pp 342-352 (2005)

Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-dependent transcriptional factor implicated in regulating adipogenesis, glucose homeostasis, and in mediating the action of the insulin sensitizing anti-diabetic thiazolidinedione (TZ

Externí odkaz: https://doaj.org/article/8f701dba02cf4e4a82b7350657759bdc

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A KCa3.1 Channel Opener, ASP0819, Modulates Nociceptive Signal Processing from Peripheral Nerves in Fibromyalgia-Like Pain in Rats

Autor: Tomoya Oe, Tetsuo Kiso, Shuichiro Kakimoto, Nobuaki Takeshita

Publikováno v: Journal of Pain Research.

Nobuaki Takeshita, Tomoya Oe, Tetsuo Kiso, Shuichiro Kakimoto Drug Discovery Research, Astellas Pharma Inc, Ibaraki, JapanCorrespondence: Nobuaki TakeshitaDrug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7abd48843c23bea3281e4bd0af5d1b9
https://www.dovepress.com/a-kca31-channel-opener-asp0819-modulates-nociceptive-signal-processing-peer-reviewed-article-JPR

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Autor: Nobuaki, Takeshita, Tomoya, Oe, Tetsuo, Kiso, Shuichiro, Kakimoto

Publikováno v: Journal of Pain Research

Purpose Although abnormal peripheral and central pain processing has been observed in fibromyalgia (FM) patients, the biomechanics and pathophysiology, surrounding the peripheral mechanism are not well understood. An intermediate conductance channel,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::081ed747ce5287e6b3a6e5e88888230c
https://pubmed.ncbi.nlm.nih.gov/33469353

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AS1069562, the (+)-Isomer of Indeloxazine, Exerts Analgesic Effects in a Rat Model of Neuropathic Pain with Unique Characteristics in Spinal Monoamine Turnover

Autor: Seiji Tamura, Tomoya Oe, Mina Tsukamoto, Ryugo Enomoto, Nobuya Matsuoka, Toshihiro Sekizawa, Toshiaki Aoki, Nozomu Hamakawa, Nobuhito Murai, Shuichiro Kakimoto

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 348:372-382

AS1069562 [(R)-2-[(1H-inden-7-yloxy)methyl]morpholine monobenzenesulfonate] is the (+)-isomer of indeloxazine, which had been used clinically for the treatment of cerebrovascular diseases with multiple pharmacological actions, including serotonin (5-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd52a664d862c3f2e29bdbe47db59e4
https://doi.org/10.1124/jpet.113.208686

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Systemic administration of 5-HT2C receptor agonists attenuates muscular hyperalgesia in reserpine-induced myalgia model

Autor: Mina Tsukamoto, Tomoya Oe, Yukinori Nagakura, Tomonari Watabiki, Yasuaki Shimizu, Hiroyuki Ito, Shin-Ichi Ogino, Tohru Ozawa

Publikováno v: Pharmacology Biochemistry and Behavior. 108:8-15

Fibromyalgia is a prevalent musculoskeletal disorder characterized by chronic widespread pain that significantly reduces quality of life in patients. Due to the lack of consistently effective treatment, the development of improved therapies for treat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18c0dad3a3b32268e318a90e8acb336
https://doi.org/10.1016/j.pbb.2013.04.007

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CyclinB2 and BIRC5 genes as surrogate biomarkers for neurite outgrowth in SH-SY5Y subclonal cells

Autor: Toshiaki Aoki, Yasuhiro Kita, Tomoya Oe, Takeyuki Nagashima, Takao Yamazaki, Masakazu Muramoto, Yoshiki Katayama, Shintaro Nishimura, Osamu Okitsu, Noriyuki Morikawa

Publikováno v: Neuropharmacology. 50:1041-1047

Neurite outgrowth plays a key role in neuronal development and regeneration, and is the hallmark assay for the effects of neurotrophic factors such as nerve growth factor (NGF). However, measuring neurite outgrowth is a slow and resource-intensive pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0994d5026cec4d2244c8045e8f514f6c
https://doi.org/10.1016/j.neuropharm.2006.02.004

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Diclofenac, a non-steroidal anti-inflammatory drug, suppresses apoptosis induced by endoplasmic reticulum stresses by inhibiting caspase signaling

Autor: Takeyuki Nagashima, Noriyuki Morikawa, Tomoya Oe, Yoshiki Katayama, Masakazu Muramoto, Shintaro Nishimura, Osamu Okitsu, Takao Yamazaki, Yasuhiro Kita

Publikováno v: Neuropharmacology. 50:558-567

Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently used in the treatment of inflammation and pain. In many reports, NSAIDs have induced apoptosis in a variety of cell lines such as colon cancer cells. On the other hand, more recently a few

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::645cf9ca8611acce07e7993203dcfca0
https://doi.org/10.1016/j.neuropharm.2005.10.016

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Differences in gene expression profile among SH-SY5Y neuroblastoma subclones with different neurite outgrowth responses to nerve growth factor

Autor: Takao Yamazaki, Toshiaki Aoki, Shintaro Nishimura, Masakazu Muramoto, Yoshiki Katayama, Noriyuki Morikawa, Tomoya Oe, Takeyuki Nagashima, Takeshi Sasayama, Yasuhiro Kita, Osamau Okitsu

Publikováno v: Journal of Neurochemistry. 94:1264-1276

Nerve growth factor (NGF) plays a key role in the differentiation of neurons. In this study, we established three NGF-induced neurite-positive (NIN+) subclones that showed high responsiveness to NGF-induced neurite outgrowth and three NGF-induced neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::decbd50ea75a326ae166da4bfdbffe65
https://doi.org/10.1111/j.1471-4159.2005.03273.x

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FK614, a Novel Peroxisome Proliferator-Activated Receptor γ Modulator, Induces Differential Transactivation Through a Unique Ligand-Specific Interaction With Transcriptional Coactivators

Autor: Naomi Hosogai, Hiroyuki Sakuma, Tomoya Oe, Seitaro Mutoh, Takao Fujimura, Chiaki Kimura, Satoko Konishi, Ichiro Aramori

Publikováno v: Journal of Pharmacological Sciences, Vol 99, Iss 4, Pp 342-352 (2005)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f9d3e7efa531a24841e942bedf9cf8
http://www.sciencedirect.com/science/article/pii/S1347861319320729

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Involvement of Chk1 Kinase in Prophase I Arrest of Xenopus Oocytes

Autor: Katsuhiro Uto, Tomoya Oe, Nobushige Nakajo, Noriyuki Sagata

Publikováno v: Developmental Biology. 207(2):432-444

Chk1 kinase, a DNA damage/replication G2 checkpoint kinase, has recently been shown to phosphorylate and inhibit Cdc25C, a Cdc2 Tyr-15 phosphatase, thereby directly linking the G2 checkpoint to negative regulation of Cdc2. Immature Xenopus oocytes ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb99ec568b03be7735a13f155deec60

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