Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Tomoya KON"'
Autor:
Tomoya Kon, Shelley L. Forrest, Seojin Lee, Jun Li, Helen Chasiotis, Nasna Nassir, Mohammed J. Uddin, Anthony E. Lang, Gabor G. Kovacs
Publikováno v:
Neurobiology of Disease, Vol 198, Iss , Pp 106551- (2024)
Multiple system atrophy (MSA) is characterized by glial cytoplasmic inclusions (GCIs) containing aggregated α-synuclein (α-syn) in oligodendrocytes. The origin of α-syn accumulation in GCIs is unclear, in particular whether abnormal α-syn aggrega
Externí odkaz:
https://doaj.org/article/9f8e98dda3ed4320bd4654f1648f7e33
Autor:
Tomoya Kon, Shelley L. Forrest, Seojin Lee, Ivan Martinez‑Valbuena, Jun Li, Nasna Nassir, Mohammed J. Uddin, Anthony E. Lang, Gabor G. Kovacs
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Misfolded α-synuclein (α-syn) is believed to contribute to neurodegeneration in Lewy body disease (LBD) based on considerable evidence including a gene-dosage effect observed in relation to point mutations and multiplication of SNCA in fam
Externí odkaz:
https://doaj.org/article/3f5a20111e77431e98b04a082450b8fc
Autor:
Takashi Nakamura, Haruo Nishijima, Fumiaki Mori, Iku Kinoshita, Tomoya Kon, Chieko Suzuki, Koichi Wakabayashi, Masahiko Tomiyama
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
BackgroundA rat model of levodopa-induced dyskinesia (LID) showed enlarged axon terminals of striatal direct pathway neurons in the internal segment of the globus pallidus (GPi) with excessive gamma-aminobutyric acid (GABA) storage in them. Massive G
Externí odkaz:
https://doaj.org/article/8e72c11db69c4f649fdb33c6c2404a46
Autor:
Fumiaki Mori, Mari Tada, Tomoya Kon, Yasuo Miki, Kunikazu Tanji, Hidekachi Kurotaki, Masahiko Tomiyama, Tomohiko Ishihara, Osamu Onodera, Akiyoshi Kakita, Koichi Wakabayashi
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract Background Amyotrophic lateral sclerosis (ALS) is characterized pathologically by the occurrence of phosphorylated TDP-43 (pTDP-43)-immunoreactive neuronal and glial inclusions in the central nervous system. Recent studies have shown that pT
Externí odkaz:
https://doaj.org/article/8eb056c89c6d461683f4ea0e7688ae21
Autor:
Tatsuya Ueno, Tamaki Kimura, Yukihisa Funamizu, Tomoya Kon, Rie Haga, Haruo Nishijima, Akira Arai, Chieko Suzuki, Jin-ichi Nunomura, Masayuki Baba, Masahiko Tomiyama
Publikováno v:
eNeurologicalSci, Vol 14, Iss , Pp 56-59 (2019)
Introduction: Although older patients with status epilepticus (SE) have a high mortality rate and poor outcome, it is difficult to perform emergent electroencephalography (EEG) to diagnose SE in community hospitals. Arterial spin labeling (ASL) is a
Externí odkaz:
https://doaj.org/article/2224f88d82ea4e5ba5e622cc1254d227
Autor:
Haruo Nishijima, Tamaki Kimura, Fumiaki Mori, Koichi Wakabayashi, Iku Kinoshita, Takashi Nakamura, Tomoya Kon, Chieko Suzuki, Masahiko Tomiyama
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
BackgroundIt remains unclear why patients with young-onset Parkinson’s disease more often develop levo-dihydroxyphenylalanine (L-dopa)-induced dyskinesia (LID) and have a more severe form than patients with old-onset Parkinson’s disease. Previous
Externí odkaz:
https://doaj.org/article/09ec6a4f7b8544d4bfa5f46563860bb6
Autor:
Haruo Nishijima, Fumiaki Mori, Akira Arai, Gang Zhu, Koichi Wakabayashi, Motohiro Okada, Shinya Ueno, Noritaka Ichinohe, Chieko Suzuki, Tomoya Kon, Masahiko Tomiyama
Publikováno v:
Neurobiology of Disease, Vol 143, Iss , Pp 104979- (2020)
Levo-dihydroxyphenylalanine (L-DOPA) is the most effective treatment for Parkinson's disease; however, most patients develop uncontrollable abnormal involuntary movements known as L-DOPA-induced dyskinesia. L-DOPA-induced dyskinesia can be reduced by
Externí odkaz:
https://doaj.org/article/00325d2a238a40c68eeeadc965d452f8
Autor:
Tatsuya Ueno, Yukihiro Hasegawa, Rie Hagiwara, Tomoya Kon, Jin-ichi Nunomura, Masahiko Tomiyama
Publikováno v:
BMC Neurology, Vol 18, Iss 1, Pp 1-5 (2018)
Abstract Background Paraneoplastic neurological syndromes (PNS) are rare disorders associated with cancer and are believed to be immune mediated. Patients with autonomic PNS suffer from variable combinations of parasympathetic and sympathetic failure
Externí odkaz:
https://doaj.org/article/ca286b81f3f24282b3ba3f139d67e259
Autor:
Tatsuya Ueno, Nobuyuki Sato, Tomoya Kon, Rie Haga, Jin-ichi Nunomura, Kazuo Nakamichi, Masayuki Saijo, Masahiko Tomiyama
Publikováno v:
BMC Neurology, Vol 18, Iss 1, Pp 1-8 (2018)
Abstract Background The development of progressive multifocal leukoencephalopathy (PML) is associated with severe cellular immunosuppression. Good’s syndrome (GS) is a rare immunodeficiency syndrome related to thymoma, with the development of humor
Externí odkaz:
https://doaj.org/article/185fef871f1545f4a1529ee8fd0325d7
Autor:
Tatsuya Ueno, Tatsuya Sasaki, Masatoshi Iwamura, Tomoya Kon, Jin-ichi Nunomura, Hiroshi Midorikawa, Masahiko Tomiyama
Publikováno v:
Case Reports in Neurology, Vol 10, Iss 1, Pp 66-71 (2018)
An 83-year-old Japanese man was admitted with dysarthria and right hemiparesis. He had had a large intracranial aneurysm on the left internal carotid artery 5 years before admission and had been followed up under conservative treatment. On admission,
Externí odkaz:
https://doaj.org/article/7646f698aadd48f1b908ba21cb5d1cd7