Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Tomotaka Yokoo"'
Autor:
Hitoshi Ogata, Yuki Yonemoto, Naoyuki Takahashi, Takahiro Ichihara, Nagahiro Ochiai, Nobuyuki Udagawa, Natsuko Fujimoto, Tatsuo Suda, Tomotaka Yokoo, Yasuhiro Kobayashi, Yasushi Okazaki, Takehiko Kato, Yutaka Nakachi, Tore Eriksson, Shinsuke Kaku, Tomokazu Ueki
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-13 (2019)
Communications Biology
Communications Biology
Osteoclasts are multinucleated cells responsible for bone resorption. The differentiation of osteoclasts from bone marrow macrophages (BMMs) is induced by receptor activator of NF-κB ligand (RANKL). Osteoprotegerin (OPG), a decoy receptor of RANKL,
Autor:
Terrence Town, Tomotaka Yokoo, Takashi Mori, Masahiro Maeda, Jun Tan, Naoki Koyama, Darrell Sawmiller, Tatsuya Segawa
Publikováno v:
J Biol Chem
Several plant-derived compounds have demonstrated efficacy in pre-clinical Alzheimer's disease (AD) rodent models. Each of these compounds share a gallic acid (GA) moiety, and initial assays on this isolated molecule indicated that it might be respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03afb591c39bc96bbf4015cdb9362b0e
https://europepmc.org/articles/PMC7705308/
https://europepmc.org/articles/PMC7705308/
Autor:
Yuta Nakano, Hui Zhao, Hitoshi Iwasaki, Tomotaka Yokoo, Motohiro Sekiya, Yoshimi Nakagawa, Hitoshi Shimano, Shigeru Yatoh, Nie Tang, Takashi Matsuzaka, Kaori Motomura, Hirohito Sone, Naoya Yahagi, Hiroaki Suzuki, Yuka Okajima, Yuichi Aita, Yoshinori Takeuchi, Nobuhiro Yamada, Song-iee Han
Publikováno v:
Diabetes. 66:1833-1846
Dysfunctional fatty acid (FA) metabolism plays an important role in the pathogenesis of β-cell dysfunction and loss of β-cell mass in type 2 diabetes (T2D). Elovl6 is a microsomal enzyme that is responsible for converting C16 saturated and monounsa
Publikováno v:
The Journal of Sexual Medicine. 12:887-896
Introduction Clinical care decisions for peripubertal adolescents with gender dysphoria (GD) should be made carefully. Furthermore, the identification of biomarkers is very important for rapid and accurate diagnosis of GD in young people. Aim The aim
Autor:
Hui, Zhao, Takashi, Matsuzaka, Yuta, Nakano, Kaori, Motomura, Nie, Tang, Tomotaka, Yokoo, Yuka, Okajima, Song-Iee, Han, Yoshinori, Takeuchi, Yuichi, Aita, Hitoshi, Iwasaki, Shigeru, Yatoh, Hiroaki, Suzuki, Motohiro, Sekiya, Naoya, Yahagi, Yoshimi, Nakagawa, Hirohito, Sone, Nobuhiro, Yamada, Hitoshi, Shimano
Publikováno v:
Diabetes. 66(7)
Dysfunctional fatty acid (FA) metabolism plays an important role in the pathogenesis of β-cell dysfunction and loss of β-cell mass in type 2 diabetes (T2D). Elovl6 is a microsomal enzyme that is responsible for converting C16 saturated and monounsa
Autor:
Nobuhiro Yamada, Yuko Endo, Naoya Yahagi, Hitoshi Shimano, Mayumi Ishikawa, Tetsuro Izumi, Takashi Matsuzaka, Satoru Takahashi, Toyonori Kato, Akimitsu Takahashi, Hiroaki Suzuki, Yoshimi Nakagawa, Takashi Yamamoto, Hirohito Sone, Hideo Toyoshima, Tomotaka Yokoo, Hiroshi Gomi, Alyssa H. Hasty, Shin Kumadaki
Publikováno v:
Cell Metabolism. 4:143-154
Granuphilin is a crucial component of the docking machinery of insulin-containing vesicles to the plasma membrane. Here, we show that the granuphilin promoter is a target of SREBP-1c, a transcription factor that controls fatty acid synthesis, and Maf
Autor:
Hideo Toyoshima, Hitoshi Shimano, Tomotaka Yokoo, Seiji Suzuki, Tadahiko Kozawa, Masakazu Mizutani, Yukichi Okuda, Yasushi Kawakami, Nobuhiro Yamada, Shigeru Yatoh, Hirohito Sone
Publikováno v:
Diabetes/Metabolism Research and Reviews. 22:38-45
Background Pericyte ghosts and acellular capillaries are well known as early histological changes resulting from diabetic retinopathy. These histological changes mean that the cell death of retinal microvessels has accelerated. It was reported that a
Autor:
Kaoruko Tada-Iida, Rumi Kihara, Akimitsu Takahashi, Hitoshi Shimano, Nobuhiro Yamada, Tomotaka Yokoo, Masatsune Suzuki, Hirotoshi Kakuta
Publikováno v:
Journal of Atherosclerosis and Thrombosis. 12:77-84
Insulin resistance plays an important role not only in the development and progression of diabetes mellitus but also in the establishment of metabolic syndrome. Improvement of insulin resistance is thus of great importance both in improving glucose m
Autor:
Masanori Nakakuki, Hitoshi Shimano, Seikoh Horiuchi, Yu-Ichiro Sakamoto, Kaoruko Iida, Hiroaki Okazaki, Yoshimi Nakagawa, Hirohito Sone, Tomotaka Yokoo, Hideo Toyoshima, Masakazu Sakai, Ken Matsuzaka, Hiroaki Suzuki, Miao Shu, Nobuhiro Yamada, Akimitsu Takahashi
Publikováno v:
Biochemical and Biophysical Research Communications. 316:790-794
The ATP-binding-cassette transporter A1 (ABCA1) plays an essential role in cellular cholesterol efflux and helps prevent macrophages from becoming foam cells. The statins are widely used as cholesterol-lowering agents and have other anti-atherogenic
Autor:
Takashi Matsuzaka, Hui Zao, Noriko Suzuki-Kemuriyama, Hitoshi Iwasaki, Kazuto Kobayashi, Yuka Okajima, Hiroaki Suzuki, Yoshimi Nakagawa, Masako Shimada, Hitoshi Shimano, Marii Suzuki, Nie Tang, Tomotaka Yokoo, Hirohito Sone, Akimitsu Takahashi, Naoya Yahagi, Motoko Kuba, Nobuhiro Yamada, Shigeru Yatoh, Yoshinori Takeuchi, Yuta Nakano
Publikováno v:
Biochemical and biophysical research communications. 450(1)
ELOVL family member 6, elongation of very long-chain fatty acids (Elovl6) is a microsomal enzyme that regulates the elongation of C12-16 saturated and monounsaturated fatty acids and is related to the development of obesity-induced insulin resistance