Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Tomoo Hirano"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
In presynaptic terminals 4 types of endocytosis, kiss-and-run, clathrin-mediated, bulk and ultrafast endocytosis have been reported to maintain repetitive exocytosis of neurotransmitter. However, detailed characteristics and relative contribution of
Externí odkaz:
https://doaj.org/article/813f90e44c9b4df1892ab59d2b9d3ae7
Publikováno v:
eLife, Vol 11 (2022)
The developing neocortex exhibits spontaneous network activity with various synchrony levels, which has been implicated in the formation of cortical circuits. We previously reported that the development of callosal axon projections, one of the major
Externí odkaz:
https://doaj.org/article/ec721a16f3af4ba5ac22ca259e77c946
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Norepinephrine modulates synaptic plasticity in various brain regions and is implicated in memory formation, consolidation and retrieval. The cerebellum is involved in motor learning, and adaptations of the vestibulo-ocular reflex (VOR) and
Externí odkaz:
https://doaj.org/article/c09abcdc535c43008ed75c376086987f
Autor:
Tomoo Hirano
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Regulation of exo- and endocytosis of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor (AMPAR) plays a critical role in the expression of synaptic plasticity such as long-term potentiation (LTP) and long-term depre
Externí odkaz:
https://doaj.org/article/82ed21013cf54bf4bb63e08e13f8ffcf
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Fast repetitive synaptic transmission depends on efficient exocytosis and retrieval of synaptic vesicles around a presynaptic active zone. However, the functional organization of an active zone and regulatory mechanisms of exocytosis, endocytosis and
Externí odkaz:
https://doaj.org/article/de9ad5cf4707457b9e30b910279a4c23
Autor:
Takuma Inoshita, Tomoo Hirano
Publikováno v:
eLife, Vol 7 (2018)
Long-term depression (LTD) at parallel fiber (PF) to Purkinje cell (PC) synapses has been considered as a main cellular mechanism for motor learning. However, the necessity of LTD for motor learning was challenged by demonstration of normal motor lea
Externí odkaz:
https://doaj.org/article/305ebcafec174d56a70521961537937c
Autor:
Hiromitsu Tanaka, Tomoo Hirano
Publikováno v:
Cell Reports, Vol 1, Iss 4, Pp 291-298 (2012)
An increase in the number of AMPA-type glutamate receptors (AMPARs) is critical for long-term potentiation (LTP), synaptic plasticity regarded as a basal mechanism of learning and memory. However, when and how each type of AMPAR reaches the postsynap
Externí odkaz:
https://doaj.org/article/784272bd4d2d4c49aa6feccf4317233d
Prediction and validation of a mechanism to control the threshold for inhibitory synaptic plasticity
Publikováno v:
Molecular Systems Biology, Vol 5, Iss 1, Pp 1-16 (2009)
Abstract Synaptic plasticity, neuronal activity‐dependent sustained alteration of the efficacy of synaptic transmission, underlies learning and memory. Activation of positive‐feedback signaling pathways by an increase in intracellular Ca2+ concen
Externí odkaz:
https://doaj.org/article/4c7c44dacc7a450a9a0ae2ed82a15538
Autor:
Yoshiaki Tagawa, Tomoo Hirano
Publikováno v:
Neural Plasticity, Vol 2012 (2012)
Callosal axon projections are among the major long-range axonal projections in the mammalian brain. They are formed during the prenatal and early postnatal periods in the mouse, and their development relies on both activity-independent and -dependent
Externí odkaz:
https://doaj.org/article/1fee9ea5260b46bda42b6d41ac714f5e
Autor:
Tomonori Takeuchi, Gen Ohtsuki, Takashi Yoshida, Masahiro Fukaya, Tasuku Wainai, Manami Yamashita, Yoshito Yamazaki, Hisashi Mori, Kenji Sakimura, Susumu Kawamoto, Masahiko Watanabe, Tomoo Hirano, Masayoshi Mishina
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2297 (2008)
In the cerebellum, Delphilin is expressed selectively in Purkinje cells (PCs) and is localized exclusively at parallel fiber (PF) synapses, where it interacts with glutamate receptor (GluR) delta2 that is essential for long-term depression (LTD), mot
Externí odkaz:
https://doaj.org/article/7fd376338e904d58b59d06c713e2f540