Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Tomonori Shibata"'
Autor:
Tomonori Shibata, Konami Nagano, Morio Ueyama, Kensuke Ninomiya, Tetsuro Hirose, Yoshitaka Nagai, Kinya Ishikawa, Gota Kawai, Kazuhiko Nakatani
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Synthetic small molecules modulating RNA structure and function have therapeutic potential for RNA diseases. Here the authors show the mechanism by which a small molecule targets the disease-causing r(UGGAA) n repeat RNAs in spinocerebellar ataxia ty
Externí odkaz:
https://doaj.org/article/fb74152ab4824a57b44c57a7b829b312
Autor:
Tomonori Shibata, Yoshihiko Fujita, Hirohisa Ohno, Yuki Suzuki, Karin Hayashi, Kaoru R. Komatsu, Shunsuke Kawasaki, Kumi Hidaka, Shin Yonehara, Hiroshi Sugiyama, Masayuki Endo, Hirohide Saito
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nucleic acid nanotechnology has great potential for future therapeutic applications. Here the authors build protein-driven RNA nanostructures that can function within mammalian cells and regulate the cell fate.
Externí odkaz:
https://doaj.org/article/6fdff867a4114dc79b8f4e117a87c7ce
Autor:
Tomonori Shibata, Yasumasa Matsumoto, Akiko Iihara, Kazunori Yamada, Hiroshi Ochiai, Ryo Saito, Shinichi Kusaka, Toshiyuki Kume
Publikováno v:
Chemical Communications. 59:5071-5074
Fluorescent indicator displacement assay using selective fluorescent indicator NBD-NCD for UGGAA repeat enables the detection of the interaction between small molecules and UGGAA repeats.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5f6f17a2278e9351f18800b6e43f33e
https://doi.org/10.1039/d3cc00837a
https://doi.org/10.1039/d3cc00837a
Autor:
Tomonori Shibata, Chikara Dohno, Yuta Hishinuma, Kaoru Saito, Masaki Hagihara, Kazuhiko Nakatani, Kazuhiro Sugimoto, Yuri Sohma
Publikováno v:
Chemistry Letters. 50:1848-1851
We demonstrate here that DNA-binding small molecules stabilize hairpin structures formed in short tandem repeat sequences, leading to efficient contractions of repeats during in vitro DNA synthesis...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37912897648f9d0d50da176efb1e0612
https://doi.org/10.1246/cl.210415
https://doi.org/10.1246/cl.210415
Autor:
Kensuke Ninomiya, Kazuhiko Nakatani, Yoshitaka Nagai, Morio Ueyama, Tomonori Shibata, Kinya Ishikawa, Tetsuro Hirose, Konami Nagano, Gota Kawai
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Synthetic small molecules modulating RNA structure and function have therapeutic potential for RNA diseases. Here we report our discovery that naphthyridine carbamate dimer (NCD) targets disease-causing r(UGGAA)n repeat RNAs in spinocerebellar ataxia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de6efcf71b3f0a75cd6fcca8acad68c
https://doaj.org/article/fb74152ab4824a57b44c57a7b829b312
https://doaj.org/article/fb74152ab4824a57b44c57a7b829b312
Publikováno v:
Handbook of Chemical Biology of Nucleic Acids ISBN: 9789811613135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ea019731ef3dea0fc74c0d83cab5ba2
https://doi.org/10.1007/978-981-16-1313-5_68-1
https://doi.org/10.1007/978-981-16-1313-5_68-1
Autor:
Tomonori Shibata, Kazuhiko Nakatani
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 79:129082
Spinocerebellar ataxia type 31 is an autosomal dominant neurodegenerative disease caused by aberrant insertion of d(TGGAA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553d68b4dc4788019e170d60ab40fc31
https://doi.org/10.1016/j.bmcl.2022.129082
https://doi.org/10.1016/j.bmcl.2022.129082
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2323
RNA-protein (RNP) complexes are promising biomaterials for the fields of nanotechnology and synthetic biology. Protein-responsive RNA sequences (RNP motifs) can be integrated into various RNAs, such as messenger RNA, short-hairpin RNA, and synthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1cf9564a4e8b76954a4a9ed46831eec0
https://pubmed.ncbi.nlm.nih.gov/34086284
https://pubmed.ncbi.nlm.nih.gov/34086284
Autor:
Tomonori Shibata, Yoshitaka Nagai, Kinya Ishikawa, Kensuke Ninomiya, Morio Ueyama, Kazuhiko Nakatani, Konami Nagano, Gota Kawai, H. Tetsuro
Synthetic small molecules modulating RNA structure and function have therapeutic potential for RNA diseases. Here we report our discovery that naphthyridine carbamate dimer (NCD) targets disease-causing r(UGGAA)n repeat RNAs in spinocerebellar ataxia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eeea3bc0dacc1400e666eadf3810075c
https://doi.org/10.1101/2020.10.05.323261
https://doi.org/10.1101/2020.10.05.323261
Autor:
Tomonori, Shibata, Konami, Nagano, Morio, Ueyama, Kensuke, Ninomiya, Tetsuro, Hirose, Yoshitaka, Nagai, Kinya, Ishikawa, Gota, Kawai, Kazuhiko, Nakatani
Publikováno v:
Nature Communications
Synthetic small molecules modulating RNA structure and function have therapeutic potential for RNA diseases. Here we report our discovery that naphthyridine carbamate dimer (NCD) targets disease-causing r(UGGAA)n repeat RNAs in spinocerebellar ataxia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::15ea8e0f5c082ef565c85b3b6fc97d0c
https://pubmed.ncbi.nlm.nih.gov/33431896
https://pubmed.ncbi.nlm.nih.gov/33431896