Výsledky vyhledávání - "Tomonori MIURA"

Akademický článek

Hydrogen Production from Ammonia Using a Plasma Membrane Reactor

Autor: Shinji Kambara, Yukio Hayakawa, Yu Inoue, Tomonori Miura

Publikováno v: Journal of Sustainable Development of Energy, Water and Environment Systems, Vol 4, Iss 2, Pp 193-202 (2016)

In this study, an efficient method for using pulsed plasma to produce hydrogen from ammonia was developed. An original pulsed plasma reactor with a hydrogen separation membrane was developed for efficient hydrogen production, and its hydrogen product

Externí odkaz: https://doaj.org/article/710562e8130b4aadaa3fcc00a331cd95

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Akademický článek

Forward and reverse dosimetry for aniline and 2,6-dimethylaniline in humans extrapolated from humanized-liver mouse data using simplified physiologically based pharmacokinetic models.

Autor: Tomonori Miura¹, Shotaro Uehara², Makiko Shimizu¹, Hiroshi Suemizu², Hiroshi Yamazaki¹ hyamazak@ac.shoyaku.ac.jp

Publikováno v: Journal of Toxicological Sciences. 2022, Vol. 47 Issue 12, p531-538. 8p.

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Akademický článek

Roles of human cytochrome P450 1A2 in coumarin 3,4-epoxidation mediated by untreated hepatocytes and by those metabolically inactivated with furafylline in previously transplanted chimeric mice.

Autor: Tomonori Miura¹, Shotaro Uehara², Makiko Shimizu¹, Norie Murayama¹, Hiroshi Suemizu², Hiroshi Yamazaki² hyamazak@ac.shoyaku.ac.jp

Publikováno v: Journal of Toxicological Sciences. 2021, Vol. 46 Issue 11, p525-530. 6p.

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Akademický článek

Pharmacokinetics of primary oxidative metabolites of thalidomide in rats and in chimeric mice humanized with different human hepatocytes.

Autor: Tomonori Miura¹, Shotaro Uehara², Makiko Shimizu¹, Hiroshi Suemizu², Hiroshi Yamazaki¹ hyamazak@ac.shoyaku.ac.jp

Publikováno v: Journal of Toxicological Sciences. 2021, Vol. 46 Issue 7, p311-317. 7p.

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Akademický článek

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Plasma Concentration Profiles for Hepatotoxic Pyrrolizidine Alkaloid Senkirkine in Humans Extrapolated from Rat Data Sets Using a Simplified Physiologically Based Pharmacokinetic Model

Autor: Hiroshi Yamazaki, Yusuke Kamiya, Tomonori Miura, Airi Kato, Norie Murayama, Makiko Shimizu

Publikováno v: Drug Metabolism and Bioanalysis Letters. 15:64-69

Aim: The main aim of the current study was to obtain forward dosimetry assessments of pyrrolizidine alkaloid senkirkine plasma and liver concentrations by setting up a human physiologically based pharmacokinetic (PBPK) model based on the limited info

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f7b8506fd97a275ba186daea102c6a
https://doi.org/10.2174/1872312801666211220110055

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Differences in Pharmacokinetics and Haematotoxicities of Aniline and Its Dimethyl Derivatives Orally Administered in Rats

Autor: Yusuke Kamiya, Makiko Shimizu, Norie Murayama, Tomonori Miura, Hiroshi Yamazaki

Publikováno v: Biological and Pharmaceutical Bulletin. 44:1775-1780

Aniline and its dimethyl derivatives reportedly become haematotoxic after metabolic N-hydroxylation of their amino groups. The plasma concentrations of aniline and its dimethyl derivatives after single oral doses of 25 mg/kg in rats were quantitative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db02fb3188a57b00732c9bf131e4658
https://doi.org/10.1248/bpb.b21-00589

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Akademický článek

Metabolic profiles of coumarin in human plasma extrapolated from a rat data set with a simplified physiologically based pharmacokinetic model.

Autor: Tomonori Miura¹, Yusuke Kamiya¹, Shiori Hina¹, Yui Kobayashi¹, Norie Murayama¹, Makiko Shimizu¹, Hiroshi Yamazaki¹ hyamazak@ac.shoyaku.ac.jp

Publikováno v: Journal of Toxicological Sciences. 2020, Vol. 45 Issue 11, p695-700. 6p.

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An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats

Autor: Yusuke Kamiya, Junya Ohori, Fumiaki Shono, Hiroshi Yamazaki, Kimito Funatsu, Tomonori Miura, Masato Kitajima, Makiko Shimizu, Kentaro Handa

Publikováno v: Chemical Research in Toxicology. 34:2180-2183

Updated algorithms for predicting the volumes of systemic circulation (V1), along with absorption rate constants and hepatic intrinsic clearances, as input parameters for physiologically based pharmacokinetic (PBPK) models were established to improve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b14c6e1400ec26e6aaeb7ea68c33b0e6
https://doi.org/10.1021/acs.chemrestox.1c00249

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Hepatotoxicological potential of P-toluic acid in humanised-liver mice investigated using simplified physiologically based pharmacokinetic models

Autor: Shotaro Uehara, Tomonori Miura, Yusuke Kamiya, Makiko Shimizu, Hiroshi Suemizu, Hiroshi Yamazaki, Norie Murayama

Publikováno v: Xenobiotica. :1-7

p-Toluic acid, a metabolite of organic solvent xylene, has a high reported no‐observed‐effect level (NOEL, 1000 mg/kg) in rats, possibly because of direct glycine conjugation to methylhippuric acid...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::452c274679dd59b7bc36990d3a8f3457
https://doi.org/10.1080/00498254.2021.1908643

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