Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Tomonori Kunikata"'
Autor:
Kimie Nakamura, Koji Fujita, Motohisa Suzuki, Akiyoshi Kunugi, Yoshihiko Hirozane, Tomonori Kunikata, Bitoku Takahashi, Genta Narazaki, Hirofumi Kondo, Shotaro Haji, Keisuke Hirai, Yuishin Izumi
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
BackgroundThe rate of disease progression varies widely among patients with amyotrophic lateral sclerosis (ALS). Prognostic assessment using biomarkers is highly anticipated to improve clinical trial design. We aimed to explore the cerebrospinal flui
Externí odkaz:
https://doaj.org/article/2ccff21420db4dd187c0d37609956739
Autor:
Tomonori Kunikata, Akira Nakao, Takeshi Shiiki, Satoru Naito, Toshihiro Kiho, Keiji Saito, Tsuyoshi Shinozuka, Yoko Nagai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1769-1773
The synthesis and structure-activity relationships of a novel series of 3-aminothieno[2,3-b]pyridine-2-carboxamides were explored. Our efforts were focused on modifying the C-4 substituent of the thienopyridine ring to develop orally available bone a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85370c94ad450ebdc70fd3d1f5f993f
https://doi.org/10.1016/j.bmcl.2019.05.014
https://doi.org/10.1016/j.bmcl.2019.05.014
Autor:
Tomonori Kunikata, Satoru Naito, Tsuyoshi Shinozuka, Akira Nakao, Daisuke Nakai, Yoko Nagai, Keiji Saito
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 54:128440
The continuing investigation of SAR of 3-aminothieno[2,3-b]pyridine-2-carboxamide derivatives has been described. In this study, C4-piperidine derivatives with polar functional groups were synthesized to develop orally available bone anabolic agents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2223c1bd3a27a6fb86e8f82e9ac51d
https://doi.org/10.1016/j.bmcl.2021.128440
https://doi.org/10.1016/j.bmcl.2021.128440
Autor:
Erica D. Koval, David R. O'Brien, Timothy M. Miller, David H. Gutmann, Tracy Cole, Nicholas J. Maragakis, Jean Philippe Richard, Theodore Hyman, Chengran Yang, Holly Kordasiewicz, Tomonori Kunikata, Joseph D. Dougherty, Rebecca L. Miller, Amy J. Wegener, Kathleen M. Schoch, Mariah L. Hoye, Tao Shen
Publikováno v:
The Journal of Neuroscience. 37:5574-5586
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder marked by the loss of motor neurons (MNs) in the brain and spinal cord, leading to fatally debilitating weakness. Because this disease predominantly affects MNs, we aimed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6847529984c988556fc2a26d6d04858a
https://doi.org/10.1523/jneurosci.3582-16.2017
https://doi.org/10.1523/jneurosci.3582-16.2017
Publikováno v:
Proceedings of The Japanese Society of Animal Models for Human Diseases. 21:27-36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02d54dea25790ad319662152f3009260
https://doi.org/10.1538/expanim1992.21.27
https://doi.org/10.1538/expanim1992.21.27
Publikováno v:
Digestion. 66:30-41
Background/Aim: Nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin produce damage in the small intestine as a major adverse reaction. We examined the effect of various NSAIDs on intestinal motility and investigated the pathogenic impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2cdc4d714a29b68d1de0f2b8809dcb
https://doi.org/10.1159/000064419
https://doi.org/10.1159/000064419
Publikováno v:
Digestive Diseases and Sciences. 47:894-904
We evaluated the effect of various PGE analogs specific to EP receptor subtypes on indomethacin-induced small intestinal lesions in rats and investigated the relationship of EP receptor subtype with the PGE action using EP receptor knockout mice. Ani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3102e98a5b4f7db3203064ebae92df8
https://doi.org/10.1023/a:1014725024519
https://doi.org/10.1023/a:1014725024519
Publikováno v:
Digestion. 63:171-179
Background/Aim: We examined the healing process of chronic gastric ulcers in adjuvant-induced arthritic rats and investigated the mechanism for delayed ulcer healing in arthritic rats, in relation to acid secretion and basic fibroblast growth factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b42a312d5b829455cc94a3c07beda0
https://doi.org/10.1159/000051886
https://doi.org/10.1159/000051886
Publikováno v:
Journal of Physiology-Paris. 95:157-163
Gastrointestinal ulcerogenic effect of indomethacin is causally related with an endogenous prostaglandin (PG) deficiency, yet the detailed mechanism remains unknown. We examined the effect of various PGE analogues specific to EP receptor subtypes on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2469b04f126c4ebcf1f0203a9ec0b7be
https://doi.org/10.1016/s0928-4257(01)00021-3
https://doi.org/10.1016/s0928-4257(01)00021-3
Publikováno v:
Journal of Physiology-Paris. 95:35-41
In the present study, we investigated a protective role of constitutively occurred nitric oxide (NO) against indomethacin-induced intestinal lesions in rats. Indomethacin (10 mg/kg) was given s.c. to animals without fasting, and the intestinal mucosa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691fd2610e0c89064c2cca47f02b11b9
https://doi.org/10.1016/s0928-4257(01)00007-9
https://doi.org/10.1016/s0928-4257(01)00007-9