Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Tomonori, Hirotani"'
Autor:
Ken Ishii, Hiroki Kato, Cevayir Coban, Masahiro Yamamoto, Shintaro Sato, Osamu Takeuchi, Shizuo Akira, Fumihiko Takeshita, Tomonori Hirotani, Satoshi Uematsu, Taro Kawai, Michiyuki Matsuda
Publikováno v:
The Journal of Experimental Medicine
Toll-like receptors (TLRs) recognize microbial pathogens and trigger innate immune responses. Among TLR family members, TLR7, TLR8, and TLR9 induce interferon (IFN)-α in plasmacytoid dendritic cells (pDCs). This induction requires the formation of a
Autor:
Masahiro Yamamoto, Satoshi Uematsu, Yutaro Kumagai, Osamu Takeuchi, Tomonori Hirotani, Shizuo Akira, Ichiro Kawase
Publikováno v:
Biochemical and Biophysical Research Communications. 328:383-392
Macrophages recognize lipopolysaccharide (LPS) by Toll-like receptor 4 and activate inflammatory responses by inducing expression of various genes. TLR4 activates intracellular signaling pathways via TIR domain containing adaptor molecules, MyD88, an
Publikováno v:
Journal of Gastroenterology. 37:56-61
Background. To assess the contribution of IL-6 signaling to the physiopathology of Crohn’s disease, we introduced anti-IL-6 receptor monoclonal antibody to a murine colitis model. Methods. Colitis was induced in C.B-17-scid mice to which were trans
Autor:
Pui Y. Lee, Hirotaka Kuwata, Kiyoshi Takeda, Masahiro Yamamoto, Tomonori Hirotani, Makoto Matsumoto, Ichiro Kawase, Shizuo Akira
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 174(6)
Macrophages play an important role in the pathogenesis of chronic colitis. However, it remains unknown how macrophages residing in the colonic lamina propria are regulated. We characterized colonic lamina proprial CD11b-positive cells (CLPMφ). CLPM
Autor:
Hideji, Nahamura, Kenya, Yoshida, Yoshihiko, Kishima, Hirayuki, Enomoto, Hirokazu, Uyama, Toshifumi, Kuroda, Yorihide, Okuda, Tomonori, Hirotani, Hiroaki, Ito, Ichiro, Kawase
Publikováno v:
Hepato-gastroenterology. 51(56)
Various circulating auto-antibodies have been reported in patients with ulcerative colitis. Hepatoma-derived growth factor (HDGF) is a mitogen, localized dominantly in the nucleus of proliferating cells. In this study, we demonstrated the circulating
Autor:
Hirokazu, Uyama, Hirayuki, Enomoto, Yoshihiko, Kishima, Mitsunari, Yamamoto, Kenya, Yoshida, Yorihide, Okuda, Tomonori, Hirotani, Toshifumi, Kuroda, Hiroaki, Ito, Masahiro, Matsuda, Minoru, Terabayashi, Sanai, Noguchi, Ichiro, Kawase, Hideji, Nakamura
Publikováno v:
Hepato-gastroenterology. 50(54)
Interferon monotherapy for patients with chronic hepatitis C has been suboptimal. We studied the effect of the combination therapy of an initial high-dose of interferon and amantadine.We investigated the virological response of 20 patients with naive
Autor:
Ichiro Kawase, Hirokazu Uyama, Yorihide Okuda, Kenya Yoshida, Hideji Nakamura, Allen D. Everett, Masanobu Funamoto, Tomonori Hirotani, Hirayuki Enomoto, Hiroaki Ito, Toshikazu Hada
Publikováno v:
Cancer science. 94(12)
Hepatoma-derived growth factor (HDGF) is highly expressed in tumor cells, and stimulates their proliferation. In the present study, we investigated the role of HDGF in tumorigenesis and elucidated the mechanism of action. Stable transfectants of NIH3
Autor:
Hideji, Nakamura, Hirokazu, Uyama, Hirayuki, Enomoto, Yoshihiko, Kishima, Mitsunari, Yamamoto, Kenya, Yoshida, Yorihide, Okuda, Tomonori, Hirotani, Toshifumi, Kuroda, Hiroaki, Ito, Masahiro, Matsuda, Minoru, Terabayashi, Sanai, Noguchi
Publikováno v:
Hepato-gastroenterology. 50(49)
The effect of interferon treatment for chronic hepatitis C patients with genotype 1b virus has been suboptimal. We studied the effect of the combination therapy of interferon and amantadine on patients with a high serum viral load of genotype 1b viru