Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Tomonari Koike"'
Autor:
Hiroaki Takeda, Yoshihiro Izumi, Masatomo Takahashi, Thanai Paxton, Shohei Tamura, Tomonari Koike, Ying Yu, Noriko Kato, Katsutoshi Nagase, Masashi Shiomi, Takeshi Bamba
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 7, Pp 1283-1293 (2018)
Lipidomics, the mass spectrometry-based comprehensive analysis of lipids, has attracted attention as an analytical approach to provide novel insight into lipid metabolism and to search for biomarkers. However, an ideal method for both comprehensive a
Externí odkaz:
https://doaj.org/article/21d21fa76bef4d198b2a2e3181893bd5
Publikováno v:
Applied Sciences, Vol 10, Iss 23, p 8681 (2020)
Hyperlipidemia or dyslipidemia is a major risk factor for atherosclerotic diseases. Experimental animals play an important role in elucidating the molecular mechanisms of the pathophysiology of hyperlipidemia as well as in drug development. Rabbits a
Externí odkaz:
https://doaj.org/article/60904fd279f34875ac82405b01b2b133
Autor:
Tomonari Koike, Yui Koike, Yanhong guo, Dongshan Yang, Jun Song, Jie Xu, Xiangjie Zhao, Tianqing Zhu, Ruiting Li, Bo Wen, Duxin Sun, Oren Rom, Renzhi Han, Jianglin Fan, Minerva T. Garcia-Barrio, Jifeng Zhang, Y. Eugene Chen
BACKGROUNDThe E3 ubiquitin ligase IDOL (Inducible Degrader of the LDL-Receptor) contributes to regulation of cholesterol metabolism through degradation of LDLR, VLDLR and ApoER2. Human genetic studies support the hypothesis that IDOL could serve as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82d32cdcc80060597b37d8f877fe7340
https://doi.org/10.1101/2022.05.03.490218
https://doi.org/10.1101/2022.05.03.490218
Autor:
Bo Yang, Linyuan Ma, Yui Koike, Brooke Pallas, Ying Yang, Mark J. Hoenerhoff, Tomonari Koike, Cheng Deng, Jifeng Zhang, Jie Xu, Y. Eugene Chen, Changzhi Zhao, Luan Wen, Jun Song, Patrick A Lester, Dongshan Yang
Publikováno v:
Stem Cell Reports
Summary Loss-of-function mutations in the forkhead box N1 (FOXN1) gene lead to nude severe combined immunodeficiency, a rare inherited syndrome characterized by athymia, severe T cell immunodeficiency, congenital alopecia, and nail dystrophy. We rece
Autor:
Yajie Chen, Ahmed Bilal Waqar, Tomonari Koike, Shuji Kitajima, Fumikazu Matsuhisa, Jifeng Zhang, Enqi Liu, Huijun Sun, Jingyan Liang, Kazutoshi Nishijima, Yuqing Eugene Chen, Lu Chen, Bo Ning, Ying Yu, Jianglin Fan
Publikováno v:
Journal of Cellular and Molecular Medicine
Matrix metalloproteinase‐9 (MMP‐9), or gelatinase B, has been hypothesized to be involved in the progression of atherosclerosis. In the arterial wall, accumulated macrophages secrete considerable amounts of MMP‐9 but its pathophysiological func
Autor:
Inbal Mor, Jianfeng Wu, Oren Rom, Lu Wang, Zhipeng Liu, Bo Wen, Jun Song, Minerva T. Garcia-Barrio, Haocheng Lu, Y. Eugene Chen, Wenying Liang, Subramaniam Pennathur, Huilun Wang, Cai Liu, Yuhao Liu, Tomonari Koike, Tony Hayek, Chuanwu Xi, Yanhong Guo, Lin Chang, Alia Ghrayeb, Eyal Gottlieb, Yui Koike, Duxin Sun, Ying Zhao, Luis Villacorta, Guizhen Zhao, Michael Aviram, Jason C. Rech, Jifeng Zhang, Wanqing Liu, Dongshan Yang, Yanbo Fan
Publikováno v:
Sci Transl Med
Nonalcoholic fatty liver disease (NAFLD) including nonalcoholic steatohepatitis (NASH) has reached epidemic proportions with no pharmacological therapy approved. Lower circulating glycine is consistently reported in patients with NAFLD, but the cause
Autor:
Yoshihiro Izumi, Hiroaki Takeda, Shohei Tamura, Tomonari Koike, Yui Koike, Takeshi Bamba, Masashi Shiomi
Publikováno v:
Journal of proteome research. 19(3)
Statins are widely used for the treatment of atherosclerotic cardiovascular diseases. They inhibit cholesterol biosynthesis in the liver and cause pleiotropic effects, including anti-inflammatory and antioxidant effects. To develop novel therapeutic
Autor:
Qingrun Li, Xiaoyue Tang, Jifeng Zhang, Tomonari Koike, Bilian Yu, Qingqing Wu, Ling Mao, Yanhong Guo, Xu Lin, Dan-Dan Wang, Y. Eugene Chen, Yui Koike, Jiarui Wu, Liang Sun, Rong Zeng, Daoquan Peng
Publikováno v:
SSRN Electronic Journal.
Background: The protein-lipid composition, namely the “quality” of lipoprotein particles, has been shown to be increasingly associated with cardiovascular disease (CVD). The high heterogeneity of lipoproteins makes it necessary to study the “qu
Publikováno v:
Journal of Atherosclerosis and Thrombosis
Aims: The relationship between the coronary artery running pattern and development of coronary lesions was re-examined herein using WHHLMI rabbits, an animal model of spontaneous coronary atherosclerosis. Methods: The coronary artery running pattern
Autor:
Shohei Tamura, Ryosuke Nagasaka, Yui Koike, Tetsuto Tsunoda, Kazuo Ogawa, Motoo Tori, Takeshi Bamba, Masashi Shiomi, Tomonari Koike, Hiroaki Takeda, Yoshihiro Izumi
Publikováno v:
European Journal of Pharmacology. 822:147-153
Improvements induced in lipid metabolism in the liver by D-47, a newly developed compound, were examined herein. WHHLMI rabbits, an animal model of hypercholesterolemia and coronary atherosclerosis, was fed D-47-supplemented chow for 5 weeks at a dos