A selective human H(4)-receptor agonist: (-)-2-cyano-1-methyl-3-[(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-y] methylguanidine

Autor: Seiichiroh Takashima, Martine J. Smit, Tomonari Imazu, Remko A. Bakker, Yumiko Yamamoto, Rob Leurs, Takushi Kurihara, Yasuhiko Sakamoto, Takeshi Hashimoto, Atsushi Yamatodani, Lisa Araki, Obbe P. Zuiderveld, Shinya Harusawa

Publikováno v: Hashimoto, T, Harusawa, S, Araki, L, Zuiderveld, O P, Smit, M J, Imazu, T, Takashima, S, Yamamoto, Y, Sakamoto, Y, Kurihara, T, Leurs, R, Bakker, R A & Yamatodani, A 2003, ' A selective human H(4)-receptor agonist: (-)-2-cyano-1-methyl-3-[(2R,5R)-5-[1H-imidazol-4(5)-yl]tetrahydrofuran-2-y] methylguanidine ', Journal of Medicinal Chemistry, vol. 46, no. 14, pp. 3162-5 . https://doi.org/10.1021/jm0300025
Journal of Medicinal Chemistry, 46(14), 3162-5. American Chemical Society

A series of 16 compounds related to chiral 4(5)-(5-aminomethyltetrahydrofuran-2-yl)imidazoles (1) have been designed, synthesized, and examined in vitro by radioligand displacement studies and functional assays for both the human H(3)- and H(4)-recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a086139f383e29104c6615adb48a6018
https://doi.org/10.1021/jm0300025

Synthesis of imifuramine and its stereoisomers exhibiting histamine H3-agonistic activity

Autor: Yumiko Yamamoto, Lisa Araki, Tomonari Imazu, Takushi Kurihara, Seiichiroh Takashima, Hirofumi Ohishi, Shinya Harusawa, Atsushi Yamatodani

Publikováno v: Tetrahedron Letters. 40:2561-2564

The four possible stereoisomers of a novel imidazole C-nucleoside derivative were synthesized by the efficient use of a PhSe group. Among them, (+)-4(5)-[(2R,5R)-5-(aminomethyl)tetrahydrofuran-2-yl]imidazole (imifuramine) was indicated as a novel typ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0653d5d054cbbb15ec2f5d6503ba9326
https://doi.org/10.1016/s0040-4039(99)00202-6

Efficient and β-Stereoselective Synthesis of 4(5)-(β-d-Ribofuranosyl)- and 4(5)-(2-Deoxyribofuranosyl)imidazoles1

Autor: Takushi Kurihara, Ryuji Yoneda, Tomonari Imazu, Hirofumi Ohishi, Shinya Harusawa, Yoshihiko Murai, Hideki Moriyama

Publikováno v: The Journal of Organic Chemistry. 61:4405-4411

A synthetic route to 4(5)-(beta-D-ribofuranosyl)imidazole (1), starting from 2,3,5-tri-O-benzyl-D-ribose (5), was developed via a Mitsunobu cyclization. Reaction of 5 with the lithium salt of bis-protected imidazole afforded the corresponding 5-ribos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f269e15b55632add3bd43f632e94ca
https://doi.org/10.1021/jo952136z

ChemInform Abstract: Efficient and β-Stereoselective Synthesis of 4(5)-Methyl-5(4)-(5- amino-5-deoxy-β-D-ribofuranosyl)imidazole and Related Compounds Exhibiting Antiulcer Activity

Autor: Hirofumi Ohishi, Ryuji Yoneda, Hiroyoshi Hata, Yasuhiko Sakamoto, Shinya Harusawa, Yoshihiko Murai, Hideki Moriyama, Tomonari Imazu, Takushi Kurihara

Publikováno v: ChemInform. 28

The reaction of 2, 3, 5-tri-O-benzyl-D-ribose with the lithium salt of an imidazole derivative gave an adduct 17RS. Treatment of 17RS with 1.5N HCl in refluxing tetrahydrofuran gave the β-4(5)-ribofuranosylimidazole 19 (35%) and the ribosylimidazole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39c7db14345b4c2cba39c7275f1c60a0
https://doi.org/10.1002/chin.199731197