Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Tomonari Hamaguchi"'
Autor:
Hiroshi Nishiwaki, Jun Ueyama, Mikako Ito, Tomonari Hamaguchi, Keiichi Takimoto, Tetsuya Maeda, Kenichi Kashihara, Yoshio Tsuboi, Hiroshi Mori, Ken Kurokawa, Masahisa Katsuno, Masaaki Hirayama, Kinji Ohno
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract We aimed to identify gut microbial features in Parkinson’s disease (PD) across countries by meta-analyzing our fecal shotgun sequencing dataset of 94 PD patients and 73 controls in Japan with five previously reported datasets from USA, Ger
Externí odkaz:
https://doaj.org/article/dcd4a11c530748f9a4fe08ed7e2c7a9e
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-8 (2023)
Abstract Parkinson’s disease (PD) is pathologically characterized by the abnormal accumulation of α-synuclein fibrils (Lewy bodies) in the substantia nigra and other brain regions, although the role of Lewy bodies remains elusive. Constipation usu
Externí odkaz:
https://doaj.org/article/94847eab5b644a1786d7270dffe7aaca
Autor:
Eri Asano-Inami, Akira Yokoi, Mai Sugiyama, Toshinori Hyodo, Tomonari Hamaguchi, Hiroaki Kajiyama
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Stress granules (SGs) are dynamic, non-membranous structures composed of non-translating mRNAs and various proteins and play critical roles in cell survival under stressed conditions. Extensive proteomics analyses have been performed to iden
Externí odkaz:
https://doaj.org/article/7da7d8b720c7464a84190bbd223c2cc5
Autor:
Hiroshi Nishiwaki, Jun Ueyama, Kenichi Kashihara, Mikako Ito, Tomonari Hamaguchi, Tetsuya Maeda, Yoshio Tsuboi, Masahisa Katsuno, Masaaki Hirayama, Kinji Ohno
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract Gut microbiota and fecal bile acids were analyzed in 278 patients with α-synucleinopathies, which were comprised of 28 patients with dementia with Lewy bodies (DLB), 224 patients with Parkinson’s disease (PD), and 26 patients with idiopat
Externí odkaz:
https://doaj.org/article/f75a7a2a06234cfcba4d87855f712657
Autor:
Hiroshi Nishiwaki, Mikako Ito, Tomonari Hamaguchi, Tetsuya Maeda, Kenichi Kashihara, Yoshio Tsuboi, Jun Ueyama, Takumi Yoshida, Hiroyuki Hanada, Ichiro Takeuchi, Masahisa Katsuno, Masaaki Hirayama, Kinji Ohno
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract To elucidate the relevance of gut dysbiosis in Parkinson’s disease (PD) in disease progression, we made random forest models to predict the progression of PD in two years by gut microbiota in 165 PD patients. The area under the receiver op
Externí odkaz:
https://doaj.org/article/7912bd23aa984e60bc79b1716143eb60
Autor:
Masaaki Hirayama, Hiroshi Nishiwaki, Tomonari Hamaguchi, Mikako Ito, Jun Ueyama, Tetsuya Maeda, Kenichi Kashihara, Yoshio Tsuboi, Kinji Ohno
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0260451 (2021)
The mortality rates of COVID-19 vary widely across countries, but the underlying mechanisms remain unelucidated. We aimed at the elucidation of relationship between gut microbiota and the mortality rates of COVID-19 across countries. Raw sequencing d
Externí odkaz:
https://doaj.org/article/a4427b6e874647a68ff3451e2dcb739f
Autor:
Hiroshi Nishiwaki, Tomonari Hamaguchi, Mikako Ito, Tomohiro Ishida, Tetsuya Maeda, Kenichi Kashihara, Yoshio Tsuboi, Jun Ueyama, Teppei Shimamura, Hiroshi Mori, Ken Kurokawa, Masahisa Katsuno, Masaaki Hirayama, Kinji Ohno
Publikováno v:
mSystems, Vol 5, Iss 6 (2020)
ABSTRACT Gut dysbiosis has been repeatedly reported in Parkinson’s disease (PD) but only once in idiopathic rapid-eye-movement sleep behavior disorder (iRBD) from Germany. Abnormal aggregation of α-synuclein fibrils causing PD possibly starts from
Externí odkaz:
https://doaj.org/article/df6d67fbd5b34d73a8d824ee6265f789
Autor:
Tetsuya Takano, Mengya Wu, Shinichi Nakamuta, Honda Naoki, Naruki Ishizawa, Takashi Namba, Takashi Watanabe, Chundi Xu, Tomonari Hamaguchi, Yoshimitsu Yura, Mutsuki Amano, Klaus M. Hahn, Kozo Kaibuchi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Emerging evidence suggests that gut microbiota influences immune function in the brain and may play a role in neurological diseases. Here, the authors offer in vivo evidence from a Drosophila model that supports a role for gut microbiota in modulatin
Externí odkaz:
https://doaj.org/article/499fc341abbe4dc59222498325b5f835
Autor:
Noriaki Gibo1,2, Tomonari Hamaguchi2, Yasuo Miki3, Takeshi Yamamura1, Masato Nakaguro4, Mikako Ito2, Masanao Nakamura1, Hiroki Kawashima5, Masaaki Hirayama6, Yoshiki Hirooka7, Koichi Wakabayashi3, Kinji Ohno2 ohnok@med.nagoya-u.ac.jp
Publikováno v:
Journal of Gastrointestinal & Liver Diseases. Sep2022, Vol. 31 Issue 3, p290-300. 11p.
Autor:
Kinji Ohno, Koichi Wakabayashi, Yoshiki Hirooka, Masaaki Hirayama, Hiroki Kawashima, Masanao Nakamuara, Mikako Ito, Masato Nakaguro, Takeshi Yamamura, Yasuo Miki, Tomonari Hamaguchi, Noriaki Gibo
Publikováno v:
Journal of Gastrointestinal and Liver Diseases. 31:290-300
Background and Aims: Parkinson’s disease (PD) is the second most neurodegenerative disease after Alzheimer’s disease. Accumulating knowledge points to the notion that abnormal aggregation of alpha-synuclein (αSyn) starts in the gut and ascends t