Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Tomonaga Ozawa"'
Autor:
Chiaki Handa, Yuki Yamazaki, Shigeru Yonekubo, Noritaka Furuya, Takaki Momose, Tomonaga Ozawa, Takayuki Furuishi, Kaori Fukuzawa, Etsuo Yonemochi
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 222
Estrogen receptors (ERs) are ligand-activated transcription factors, with two subtypes ERα and ERβ. The endogenous ligand of ERs is the common 17β-estradiol, and the ligand-binding pocket of ERα and ERβ is very similar. Nevertheless, some ERβ-s
Autor:
Shunpei Nagase, Hitomi Yuki, Noriyuki Kurita, Teruki Honma, Shigenori Tanaka, Daisuke Takaya, Kikuko Kamisaka, Yoshio Okiyama, Midori Takimoto-Kamimura, Hirotomo Moriwaki, Yoichiro Yagi, Tatsuya Takagi, Norihito Kawashita, Kenichiro Takaba, Tomohiro Sato, Tomonaga Ozawa, Chiduru Watanabe, Kaori Fukuzawa
Publikováno v:
Journal of Chemical Information and Modeling. 61:777-794
We developed the world's first web-based public database for the storage, management, and sharing of fragment molecular orbital (FMO) calculation data sets describing the complex interactions between biomacromolecules, named FMO Database (https://dru
Autor:
Tomonaga Ozawa, Motoyasu Ozawa
Publikováno v:
Recent Advances of the Fragment Molecular Orbital Method ISBN: 9789811592348
The structures of target proteins and ligands provide essential information to drug discovery researchers, especially medicinal chemists and computational chemists. They use the structural information to design novel ligands by considering the molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74121e0dade6c4725176e6ed9e57e264
https://doi.org/10.1007/978-981-15-9235-5_10
https://doi.org/10.1007/978-981-15-9235-5_10
Publikováno v:
ACS Medicinal Chemistry Letters. 8:660-665
Photoaffinity labeling (PAL) is widely used for the identification of ligand-binding proteins and elucidation of ligand-binding sites. PAL has also been employed for the characterization of G protein-coupled receptors (GPCRs); however, a limited numb
Autor:
Yoshikazu Fujimori, Noboru Kamada, Tomonaga Ozawa, Osamu Nakanishi, Tetsuya Ikeda, Tetsuji Ozawa, Hiroo Takeda, Jun-ichi Kobayashi, Hideaki Hirasawa
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:727-742
Transient receptor potential melastatin 8 (TRPM8) is activated by innocuous cold and chemical substances, and antagonists of this channel have been considered to be effective for pain and urinary diseases. N-(3-aminopropyl)-2-{[(3-methylphenyl)methyl
Publikováno v:
ACS medicinal chemistry letters. 8(6)
Photoaffinity labeling (PAL) is widely used for the identification of ligand-binding proteins and elucidation of ligand-binding sites. PAL has also been employed for the characterization of G protein-coupled receptors (GPCRs); however, a limited numb
Publikováno v:
Journal of molecular graphicsmodelling. 75
The streptavidin-biotin complex has an extraordinarily high affinity (Ka: 1015 mol−1) and contains one of the strongest non-covalent interactions known. This strong interaction is widely used in biological tools, including for affinity tags, detect
Publikováno v:
Photoaffinity Labeling for Structural Probing Within Protein ISBN: 9784431565680
Photoaffinity labeling (PAL) is a method that forms an irreversible covalent bond between photoreactive ligands and neighboring amino acids under the irradiation of light. PAL is utilized in the pharmacological and biochemical identification of ligan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13d1830244dc741395431d10f2c060f1
https://doi.org/10.1007/978-4-431-56569-7_12
https://doi.org/10.1007/978-4-431-56569-7_12
Publikováno v:
Journal of molecular graphicsmodelling. 74
The molecular interactions of inhibitors of bromodomains (BRDs) were investigated. BRDs are protein interaction modules that recognizing e-N-acetyl-lysine (eAc-Lys) motifs found in histone tails and are promising protein-protein interaction (PPI) tar
Publikováno v:
Journal of Computational Chemistry. 32:2774-2782
We examined CH/π hydrogen bonds in protein/ligand complexes involving at least one proline residue using the ab initio fragment molecular orbital (FMO) method and the program CHPI. FMO calculations were carried out at the Hartree–Fock (HF)/6-31G*,