Výsledky vyhledávání - "Tomona Hirano"

A randomized, placebo‐controlled study to evaluate the efficacy and safety of adding omarigliptin to insulin therapy in Japanese patients with type 2 diabetes and inadequate glycaemic control

Autor: Miho Kameya, Tomona Hirano, Yutaka Seino, Nobuyuki Oshima, Samuel S. Engel, Taro Okamoto, Edward A. O'Neill, Ira Gantz, Takashi Kadowaki, Asako Sato, Kohei Kaku

Publikováno v: Diabetes, Obesity & Metabolism

Aim To evaluate the efficacy and safety of adding the once‐weekly oral dipeptidyl peptidase‐4 inhibitor omarigliptin to treatment of Japanese patients with type 2 diabetes and inadequate glycaemic control on insulin monotherapy. Materials and Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1a96d68d978ceebe14be15b7750341
https://doi.org/10.1111/dom.14331

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HCV evolutionary genetics of SVR versus virologic failure assessed from the vaniprevir phase III registration trials

Autor: Keisuke Nakamura, Wei Chang, Stuart Black, Steven W. Ludmerer, Anita Y. M. Howe, Tomona Hirano, Akiko Takase, David C. Nickle, Norio Hayashi, Yoshiyuki Tanaka, Hiromitsu Kumada

Publikováno v: Antiviral Research. 130:118-129

In the phase III registration studies conducted in Japan, Japanese HCV gt1 patients administered vaniprevir 300 mg twice daily plus pegylated interferon/ribavirin for 12 or 24 weeks achieved SVR24 rates of 83.7–84.5% among treatment-naive patients,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8afa6c4fd17dbe9ce9facbfd29bebbae
https://doi.org/10.1016/j.antiviral.2016.03.004

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Possible Involvement of CPI-17 in Augmented Bronchial Smooth Muscle Contraction in Antigen-Induced Airway Hyper-Responsive Rats

Autor: Miwa Misawa, Hiroyasu Sakai, Yoshihiko Chiba, Tomona Hirano

Publikováno v: Molecular Pharmacology. 68:145-151

Airway hyper-responsiveness (AHR) associated with heightened airway resistance and inflammation is a characteristic feature of asthma. It has been demonstrated that contractile responsiveness and Ca(2+) sensitization to acetylcholine (ACh) in repeate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41db256266e10d7b72bf0afeb7642983
https://doi.org/10.1124/mol.104.004325

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Acetylcholine-induced phosphorylation of CPI-17 in rat bronchial smooth muscle: the roles of Rho-kinase and protein kinase C

Autor: Hisao Takeyama, Hiroyasu Sakai, Tomona Hirano, Yoshihiko Chiba, Miwa Misawa

Publikováno v: Canadian Journal of Physiology and Pharmacology. 83:375-381

It has been demonstrated that CPI-17 provokes an inhibition of myosin light chain phosphatase to increase myosin light chain phosphorylaton and Ca2+sensitivity during contraction of vascular smooth muscle. However, expression and agonist-mediated reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::627b1d27a4a4a7455dde7497bd7f63d4
https://doi.org/10.1139/y05-022

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