Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

Autor: Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, Mikio Hoshino, Akito Nakao, Yasuo Mori, Shigeo Okabe, Masayuki Matsushita, Anja Urbach, Yuta Katayama, Akinobu Matsumoto, Keiichi I Nakayama, Shota Katori, Takuya Sato, Takuji Iwasato, Haruko Nakamura, Yoshio Goshima, Matthieu Raveau, Tetsuya Tatsukawa, Kazuhiro Yamakawa, Noriko Takahashi, Haruo Kasai, Johji Inazawa, Ikuo Nobuhisa, Tetsushi Kagawa, Tetsuya Taga, Mohamed Darwish, Hirofumi Nishizono, Keizo Takao, Kiran Sapkota, Kazutoshi Nakazawa, Tsuyoshi Takagi, Haruki Fujisawa, Yoshihisa Sugimura, Kyosuke Yamanishi, Lakshmi Rajagopal, Nanette Deneen Hannah, Herbert Y Meltzer, Tohru Yamamoto, Shuji Wakatsuki, Toshiyuki Araki, Katsuhiko Tabuchi, Tadahiro Numakawa, Hiroshi Kunugi, Freesia L Huang, Atsuko Hayata-Takano, Hitoshi Hashimoto, Kota Tamada, Toru Takumi, Takaoki Kasahara, Tadafumi Kato, Isabella A Graef, Gerald R Crabtree, Nozomi Asaoka, Hikari Hatakama, Shuji Kaneko, Takao Kohno, Mitsuharu Hattori, Yoshio Hoshiba, Ryuhei Miyake, Kisho Obi-Nagata, Akiko Hayashi-Takagi, Léa J Becker, Ipek Yalcin, Yoko Hagino, Hiroko Kotajima-Murakami, Yuki Moriya, Kazutaka Ikeda, Hyopil Kim, Bong-Kiun Kaang, Hikari Otabi, Yuta Yoshida, Atsushi Toyoda, Noboru H Komiyama, Seth GN Grant, Michiru Ida-Eto, Masaaki Narita, Ken-ichi Matsumoto, Emiko Okuda-Ashitaka, Iori Ohmori, Tadayuki Shimada, Kanato Yamagata, Hiroshi Ageta, Kunihiro Tsuchida, Kaoru Inokuchi, Takayuki Sassa, Akio Kihara, Motoaki Fukasawa, Nobuteru Usuda, Tayo Katano, Teruyuki Tanaka, Yoshihiro Yoshihara, Michihiro Igarashi, Takashi Hayashi, Kaori Ishikawa, Satoshi Yamamoto, Naoya Nishimura, Kazuto Nakada, Shinji Hirotsune, Kiyoshi Egawa, Kazuma Higashisaka, Yasuo Tsutsumi, Shoko Nishihara, Noriyuki Sugo, Takeshi Yagi, Naoto Ueno, Tomomi Yamamoto, Yoshihiro Kubo, Rie Ohashi, Nobuyuki Shiina, Kimiko Shimizu, Sayaka Higo-Yamamoto, Katsutaka Oishi, Hisashi Mori, Tamio Furuse, Masaru Tamura, Hisashi Shirakawa, Daiki X Sato, Yukiko U Inoue, Takayoshi Inoue, Yuriko Komine, Tetsuo Yamamori, Kenji Sakimura, Tsuyoshi Miyakawa

Publikováno v: eLife, Vol 12 (2024)

Increased levels of lactate, an end-product of glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These changes in lactate levels can result in decreased brain pH, which has been implicate

Externí odkaz: https://doaj.org/article/15de117935204a21a8487997042e8094

Analysis of the epidermal growth factor receptor/phosphoinositide‐dependent protein kinase‐1 axis in tumor of the external auditory canal in response to epidermal growth factor stimulation

Autor: Naotaro Akiyama, Tomomi Yamamoto‐Fukuda, Mamoru Yoshikawa, Hiromi Kojima

Publikováno v: Laryngoscope Investigative Otolaryngology, Vol 7, Iss 3, Pp 730-739 (2022)

Abstract Objectives The epidermal growth factor receptor (EGFR) is related to the invasion and metastasis of external auditory canal (EAC) squamous cell carcinoma (SCC). The phosphoinositide‐dependent protein kinase‐1 (PDPK1) accelerates tumor ce

Externí odkaz: https://doaj.org/article/a6f415ff97aa4bc1918c00b599f50c1e

Evaluation of Performance in Colon Capsule Endoscopy Reading by Endoscopy Nurses

Autor: Yukiko Handa, Konosuke Nakaji, Kayo Hyogo, Makiko Kawakami, Tomomi Yamamoto, Akiko Fujiwara, Rika Kanda, Motoyasu Osawa, Osamu Handa, Hiroshi Matsumoto, Eiji Umegaki, Akiko Shiotani

Publikováno v: Canadian Journal of Gastroenterology and Hepatology, Vol 2021 (2021)

Background. Although there are papers reporting on the accuracy of colon capsule endoscopy (CCE) compared with colonoscopy (CS), there are few reports on the detection rates of significant lesions by endoscopy nurses. We previously reported no signif

Externí odkaz: https://doaj.org/article/4daf72063aff4da5afb3bb6b7454597c

Amelioration by the Natural Polyamine Spermine of Cartilage and Bone Destruction in Rats With Collagen-Induced Arthritis

Autor: Takashi Iezaki, Eiichi Hinoi, Tomomi Yamamoto, Ryo Ishiura, Shinya Ogawa, Yukio Yoneda

Publikováno v: Journal of Pharmacological Sciences, Vol 119, Iss 1, Pp 107-111 (2012)

We investigated pharmacological properties of naturally occurring polyamines on cartilage and bone destruction seen in joints of rats with collagen-induced arthritis (CIA). Daily supplementation of spermine (SPM), but not spermidine, significantly in

Externí odkaz: https://doaj.org/article/95217342d42445fda67a108dff77a044

Bilateral Cochlear Implantation for Children in Nagasaki, Japan

Autor: Yukihiko Kanda, Hidetaka Kumagami, Minoru Hara, Yuzuru Sainoo, Chisei Sato, Tomomi Yamamoto-Fukuda, Haruo Yoshida, Akiko Ito, Chiharu Tanaka, Kyoko Baba, Ayaka Nakata, Hideo Tanaka, Haruo Takahashi

Publikováno v: Clinical and Experimental Otorhinolaryngology, Vol 5, Iss Suppl 1, Pp S24-S31 (2012)

ObjectivesThe number of patients with bilateral cochlear implant (CI) has gradually increased as patients and/or parents recognize its effectiveness. The purpose of this report is to evaluate the efficacy of 29 bilateral CI out of 169 pediatric CI us

Externí odkaz: https://doaj.org/article/a9be3e11b7b044a0b4977a5907203909