Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Tomomi Kurashige"'
Autor:
Tomomi Kurashige, Mika Shimamura, Koichiro Hamada, Michiko Matsuse, Norisato Mitsutake, Yuji Nagayama
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Oncocytic thyroid cancer is characterized by the aberrant accumulation of abnormal mitochondria in the cytoplasm and a defect in oxidative phosphorylation. We performed metabolomics analysis to compare metabolic reprogramming among the oncoc
Externí odkaz:
https://doaj.org/article/aa186c38945b4ca48628e3d30633bc4c
Autor:
Mutsumi Matsuu-Matsuyama, Kazuko Shichijo, Katsuya Matsuda, Nariaki Fujimoto, Hisayoshi Kondo, Shiro Miura, Tomomi Kurashige, Yuji Nagayama, Masahiro Nakashima
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Childhood radiation exposure is a known thyroid cancer risk factor. This study evaluated the effects of age on radiation-induced thyroid carcinogenesis in rats irradiated with 8 Gy X-rays. We analyzed cell proliferation, cell death, DNA dama
Externí odkaz:
https://doaj.org/article/d666540cb0a144dea163b11c33a132ac
Autor:
Koichiro Hamada, Tomomi Kurashige, Mika Shimamura, Hirofumi Arakawa, Yasuyuki Nakamura, Yuji Nagayama
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Mitochondria-eating protein (MIEAP) is a molecule important for non-canonical mitophagy and thought to be a tumor suppressor. Our previous study found that MIEAP expression is defective in thyroid oncocytomas, irrespective of being benign or malignan
Externí odkaz:
https://doaj.org/article/ba1cff7cc1914b228fbd6b320be1a098
Autor:
Mika Shimamura, Nobuyuki Shibusawa, Tomomi Kurashige, Zhanna Mussazhanova, Hiroki Matsuzaki, Masahiro Nakashima, Masanobu Yamada, Yuji Nagayama
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201365 (2018)
The BRAFV600E mutation is the most prevalent driver mutation of sporadic papillary thyroid cancers (PTC). It was previously shown that prenatal or postnatal expression of BRAFV600E under elevated TSH levels induced thyroid cancers in several genetica
Externí odkaz:
https://doaj.org/article/520e9d93e1604a43beac3494bc323b08
Publikováno v:
Endocrine journal. 69(7)
Numerous studies have examined the role of autophagy in thyroid cancer treatment; however there are discrepancies among the reported data, with some showing the pro-survival and others the anti-survival effects of autophagy. These discrepant results
Autor:
Mika Shimamura, Tomomi Kurashige, Masahiro Nakashima, Zhanna Mussazhanova, Masahiro Ito, Yuji Nagayama
Publikováno v:
Cancer Science
Oncocytic cell tumor of the thyroid is composed of large polygonal cells with eosinophilic cytoplasm that is rich in mitochondria. These tumors frequently have the mutations in mitochondrial DNA encoding the mitochondrial electron transport system co
Publikováno v:
Endocrine. 69:571-577
Transforming growth factor-β (TGFβ) has pleiotropic actions, including both anti- and pro-tumorigenic abilities. We have previously shown no tumor development in the thyroid-specific TGFβ receptor type II knockout (Tgfβr2 KO) mice, indicating the
Autor:
Masahiro Nakashima, Mutsumi Matsuu-Matsuyama, Katsuya Matsuda, Tomomi Kurashige, Kazuko Shichijo, Hisayoshi Kondo, Shiro Miura, Nariaki Fujimoto, Yuji Nagayama
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Childhood radiation exposure is a known thyroid cancer risk factor. This study evaluated the effects of age on radiation-induced thyroid carcinogenesis in rats irradiated with 8 Gy X-rays. We analyzed cell proliferation, cell death, DNA damage respon
Autor:
Yuji Nagayama, Mika Shimamura, Mutsumi Matsuyama, Yasuyo Nakajima, Masanobu Yamada, Tomomi Kurashige, Masahiro Nakashima
Publikováno v:
Endocrinology. 160:2085-2092
Autophagy is a catabolic process that involves the degradation of cellular components through the lysosomal machinery, relocating nutrients from unnecessary processes to more pivotal processes required for survival. It has been reported that systemic
Publikováno v:
Journal of the Endocrine Society
Autophagy is an evolutionarily conserved catabolic process by which cells degrade intracellular proteins and organelles in the lysosomes and recycle their metabolites. We have recently demonstrated the crucial role for the basal level of autophagic a