Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Tomomi Aida"'
Autor:
Myung Chung, Katsutoshi Imanaka, Ziyan Huang, Akiyuki Watarai, Mu-Yun Wang, Kentaro Tao, Hirotaka Ejima, Tomomi Aida, Guoping Feng, Teruhiro Okuyama
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Individuals with autism spectrum disorder (ASD) have a higher prevalence of social memory impairment. A series of our previous studies revealed that hippocampal ventral CA1 (vCA1) neurons possess social memory engram and that the neurophysio
Externí odkaz:
https://doaj.org/article/79238030dcf642b9aeaace59e4742e46
Autor:
Dheeraj S. Roy, Young-Gyun Park, Minyoung E. Kim, Ying Zhang, Sachie K. Ogawa, Nicholas DiNapoli, Xinyi Gu, Jae H. Cho, Heejin Choi, Lee Kamentsky, Jared Martin, Olivia Mosto, Tomomi Aida, Kwanghun Chung, Susumu Tonegawa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Where memories are located in our brains is not well understood. In this paper, the authors demonstrate that memories are spread out throughout multiple brain regions.
Externí odkaz:
https://doaj.org/article/e5aea36753e14795b29ae4633581dc90
Autor:
Wenhui Zhang, Tomomi Aida, Ricardo C. H. del Rosario, Jonathan J. Wilde, Chenhui Ding, Xiaohui Zhang, Zulqurain Baloch, Yan Huang, Yu Tang, Duanduan Li, Hongyu Lu, Yang Zhou, Minqing Jiang, Dongdong Xu, Zhihao Fang, Zhanhong Zheng, Qunshan Huang, Guoping Feng, Shihua Yang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Due to the polygenic nature of most diseases, simultaneous correction or introduction of single nucleotide variants is needed. Here, the authors demonstrated the feasibility of multiplex base editing for polygenes disease modeling in cynomolgus monke
Externí odkaz:
https://doaj.org/article/f12a1f3a3f2f43fcbc1cc1633d33b500
Autor:
Yoshifumi Abe, Norio Takata, Yuki Sakai, Hiro Taiyo Hamada, Yuichi Hiraoka, Tomomi Aida, Kohichi Tanaka, Denis Le Bihan, Kenji Doya, Kenji F Tanaka
Publikováno v:
NeuroImage, Vol 223, Iss , Pp 117318- (2020)
Diffusion functional magnetic resonance imaging (DfMRI) has been proposed as an alternative functional imaging method to detect brain activity without confounding hemodynamic effects. Here, taking advantage of this DfMRI feature, we investigated abno
Externí odkaz:
https://doaj.org/article/5135297929c14ac1afedf94662dc7293
Autor:
Shota Nakade, Keiji Mochida, Atsushi Kunii, Kazuki Nakamae, Tomomi Aida, Kohichi Tanaka, Naoaki Sakamoto, Tetsushi Sakuma, Takashi Yamamoto
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Genome editing using CRISPR can be enhanced by manipulating DNA double-strand break repair pathways. Here the authors demonstrate LoAD, local accumulation of repair molecules, which shifts repair to microhomology-mediated end-joining.
Externí odkaz:
https://doaj.org/article/7714049adc384aa7a9920f7849997032
Autor:
Yoshiki Miyasaka, Yoshihiro Uno, Kazuto Yoshimi, Yayoi Kunihiro, Takuji Yoshimura, Tomohiro Tanaka, Harumi Ishikubo, Yuichi Hiraoka, Norihiko Takemoto, Takao Tanaka, Yoshihiro Ooguchi, Paul Skehel, Tomomi Aida, Junji Takeda, Tomoji Mashimo
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-8 (2018)
Abstract Background CRISPR/Cas9 enables the targeting of genes in zygotes; however, efficient approaches to create loxP-flanked (floxed) alleles remain elusive. Results Here, we show that the electroporation of Cas9, two gRNAs, and long single-strand
Externí odkaz:
https://doaj.org/article/226795467b9f47eebef2789b9696428e
Autor:
Rolen M. Quadros, Hiromi Miura, Donald W. Harms, Hisako Akatsuka, Takehito Sato, Tomomi Aida, Ronald Redder, Guy P. Richardson, Yutaka Inagaki, Daisuke Sakai, Shannon M. Buckley, Parthasarathy Seshacharyulu, Surinder K. Batra, Mark A. Behlke, Sarah A. Zeiner, Ashley M. Jacobi, Yayoi Izu, Wallace B. Thoreson, Lisa D. Urness, Suzanne L. Mansour, Masato Ohtsuka, Channabasavaiah B. Gurumurthy
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-15 (2017)
Abstract Background Conditional knockout mice and transgenic mice expressing recombinases, reporters, and inducible transcriptional activators are key for many genetic studies and comprise over 90% of mouse models created. Conditional knockout mice a
Externí odkaz:
https://doaj.org/article/cc09dd43b09b4403b9ad7415943adf1e
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36853 (2012)
BACKGROUND: Brains of patients with schizophrenia show both neurodevelopmental and functional deficits that suggest aberrant glutamate neurotransmission. Evidence from both genetic and pharmacological studies suggests that glutamatergic dysfunction,
Externí odkaz:
https://doaj.org/article/3a06d25e40314c08aa8affbfafff051b
Autor:
Takahiro Ito, Mikio Yoshida, Tomomi Aida, Itaru Kushima, Yuka Hiramatsu, Maiko Ono, Akira Yoshimi, Kohichi Tanaka, Norio Ozaki, Yukihiro Noda
Publikováno v:
Journal of Neurochemistry. 165:211-229
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42e62f016f54eb54da76941733f9fe1a
https://doi.org/10.1111/jnc.15790
https://doi.org/10.1111/jnc.15790
Autor:
Yosuke M. Morizawa, Mami Matsumoto, Yuka Nakashima, Narumi Endo, Tomomi Aida, Hiroshi Ishikane, Kaoru Beppu, Satoru Moritoh, Hitoshi Inada, Noriko Osumi, Eiji Shigetomi, Schuichi Koizumi, Guang Yang, Hirokazu Hirai, Kohichi Tanaka, Kenji F. Tanaka, Nobuhiko Ohno, Yugo Fukazawa, Ko Matsui
Publikováno v:
Nature Neuroscience. 25:1458-1469
Synaptic pruning is a fundamental process of neuronal circuit refinement in learning and memory. Accumulating evidence suggests that glia participates in sculpting the neuronal circuits through synapse engulfment. However, whether glial involvement i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350e14d4d2dda9687414ccbacc3543e5
https://doi.org/10.1038/s41593-022-01184-5
https://doi.org/10.1038/s41593-022-01184-5