Data from Diminished Sensitivity of Chronic Lymphocytic Leukemia Cells to ABT-737 and ABT-263 Due to Albumin Binding in Blood

Autor: Gerald M. Cohen, Martin J.S. Dyer, Tomomi Kuwana, Manfred Jung, Silviya D. Furdas, Meike Vogler

Purpose: Inhibition of the antiapoptotic BCL2 family is one of the most promising areas of anticancer drug development. However, ABT-737, a specific BCL2 inhibitor, is neither orally bioavailable nor metabolically stable. To overcome these problems,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21372bce90f65aab247537aec092e041
https://doi.org/10.1158/1078-0432.c.6518951

Calcium signals regulate the functional differentiation of thymic iNKT cells

Autor: Chen Zhang, Anne N. Murphy, Patrick G. Hogan, Ariel Quintana, Alexander Y Andreyev, William B. Kiosses, Meng Zhao, Mitchell Kronenberg, Tomomi Kuwana

Publikováno v: EMBO J

How natural or innate‐like lymphocytes generate the capacity to produce IL‐4 and other cytokines characteristic of type 2 immunity remains unknown. Invariant natural killer T (iNKT) cells differentiate in the thymus into NKT1, NKT2, and NKT17 sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09416cad35ebda5d4b86ef109e26ecd
https://europepmc.org/articles/PMC8365263/

Bax activation initiates the assembly of a multimeric catalyst that facilitates Bax pore formation in mitochondrial outer membranes.

Autor: Yulia Kushnareva, Alexander Y Andreyev, Tomomi Kuwana, Donald D Newmeyer

Publikováno v: PLoS Biology, Vol 10, Iss 9, p e1001394 (2012)

Bax/Bak-mediated mitochondrial outer membrane permeabilization (MOMP) is essential for "intrinsic" apoptotic cell death. Published studies used synthetic liposomes to reveal an intrinsic pore-forming activity of Bax, but it is unclear how other mitoc

Externí odkaz: https://doaj.org/article/bbec65240fff4ac3a58801053c0a5789

Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization

Autor: Tomomi Kuwana, Julian Suess, Louise E. King, Katia Cosentino, Donald D. Newmeyer, Andrew P. Gilmore, Ana J. García-Sáez

Publikováno v: J Biol Chem
Kuwana, T, King, L E, Cosentino, K, Suess, J, García-sáez, A J, Gilmore, A P & Newmeyer, D D 2020, ' Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization ', Journal of Biological Chemistry, pp. jbc.RA119.011635 . https://doi.org/10.1074/jbc.RA119.011635

Permeabilization of the mitochondrial outer membrane is a key step in the intrinsic apoptosis pathway, triggered by the release of mitochondrial intermembrane space proteins into the cytoplasm. The BCL-2-associated X apoptosis regulator (BAX) protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4727bc3df6df9bc59c28439e02ae66
https://pubmed.ncbi.nlm.nih.gov/31901077

Cryo-Electron Microscopy to Study Bax Pores and MOMP

Autor: Tomomi, Kuwana

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1877

During apoptosis, mitochondria permeabilize the outer membranes to release apoptogenic proteins from the intermembrane space. This process termed mitochondrial outer membrane permeabilization (MOMP) is regulated by Bcl-2 family proteins. Bax is an ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7164fadc3a2b77f06f8bca6d381e3ba5
https://pubmed.ncbi.nlm.nih.gov/30536011