Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Tomoko Wakabayashi"'
Autor:
Tadafumi Hashimoto, Daisuke Fujii, Yasushi Naka, Mayu Kashiwagi-Hakozaki, Yuko Matsuo, Yusuke Matsuura, Tomoko Wakabayashi, Takeshi Iwatsubo
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-18 (2020)
Abstract Massive deposition of amyloid β peptides (Aβ) as senile plaques (SP) characterizes the brain pathology of Alzheimer’s disease (AD). SPs exhibit a variety of morphologies, although little is known about the SP components that determine th
Externí odkaz:
https://doaj.org/article/f30fc230e2c14ed3b0912241e753772d
Autor:
Toshitaka Ochiai, Toshiharu Sano, Takeru Nagayama, Naoto Kubota, Takashi Kadowaki, Tomoko Wakabayashi, Takeshi Iwatsubo
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105510- (2021)
Insulin signaling has been implicated in the metabolism as well as aging and longevity. Type 2 diabetes mellitus and its core pathology, insulin resistance, has also been implicated in the development of Alzheimer's disease (AD) and amyloid-β deposi
Externí odkaz:
https://doaj.org/article/1bc58fc2b77e4026bf523285f50bb0ab
Autor:
Tomoko Wakabayashi, Kazuki Yamaguchi, Kentaro Matsui, Toshiharu Sano, Tetsuya Kubota, Tadafumi Hashimoto, Ayako Mano, Kaoru Yamada, Yuko Matsuo, Naoto Kubota, Takashi Kadowaki, Takeshi Iwatsubo
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-18 (2019)
Abstract Background Based on epidemiological and experimental studies, type 2 diabetes mellitus (T2DM), especially insulin resistance that comprises the core mechanism of T2DM, has been recognized as a significant risk factor for Alzheimer’s diseas
Externí odkaz:
https://doaj.org/article/5c9873e539af42909939d09c0139f91b
Autor:
Tomoko Wakabayashi
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2021)
Neuromuscular development is a multistep process and involves interactions among various extracellular and transmembrane molecules that facilitate the precise targeting of motor axons to synaptogenic regions of the target muscle. Collagenous proteins
Externí odkaz:
https://doaj.org/article/54de604288f1459590c07de15ee02acc
Autor:
Noel E. Kelty, Tomoko Wakabayashi
Publikováno v:
SAGE Open, Vol 10 (2020)
How engaged families are in their children’s lives, whether at home or in school, predicts their success in school and in life. The purpose of this study was to explore parent, educator, and community member perspectives of family engagement, presc
Externí odkaz:
https://doaj.org/article/9bbe88b426294e9b986759f5ccb61f0e
Autor:
Haruka Munezane, Hiroaki Oizumi, Tomoko Wakabayashi, Shu Nishio, Tomoko Hirasawa, Takashi Sato, Akihiro Harada, Tomoyuki Yoshida, Takahiro Eguchi, Yuji Yamanashi, Tadafumi Hashimoto, Takeshi Iwatsubo
Publikováno v:
Cell Reports, Vol 29, Iss 13, Pp 4362-4376.e6 (2019)
Summary: Intramuscular motor innervation is an essential process in neuromuscular development. Recently, mutations in COL25A1, encoding CLAC-P/collagen XXV, have been linked to the development of a congenital cranial dysinnervation disorder (CCDD). Y
Externí odkaz:
https://doaj.org/article/9f7b9257524b4cf0896c2cc86be8f09d
Autor:
Kaoru Yamamoto, Zen-ichi Tanei, Tadafumi Hashimoto, Tomoko Wakabayashi, Hiroyuki Okuno, Yasushi Naka, Ofer Yizhar, Lief E. Fenno, Masashi Fukayama, Haruhiko Bito, John R. Cirrito, David M. Holtzman, Karl Deisseroth, Takeshi Iwatsubo
Publikováno v:
Cell Reports, Vol 11, Iss 6, Pp 859-865 (2015)
In vivo experimental evidence indicates that acute neuronal activation increases Aβ release from presynaptic terminals, whereas long-term effects of chronic synaptic activation on Aβ pathology remain unclear. To address this issue, we adopted optog
Externí odkaz:
https://doaj.org/article/735a025e6b604e8cb7fe218382bd6e3a
Autor:
Toshiharu Sano, Toshitaka Ochiai, Takeru Nagayama, Ayaka Nakamura, Naoto Kubota, Takashi Kadowaki, Tomoko Wakabayashi, Takeshi Iwatsubo
Publikováno v:
Journal of Neuroscience; 10/25/2023, Vol. 43 Issue 43, p7226-7241, 16p
Autor:
Noel E. Kelty, Tomoko Wakabayashi
Publikováno v:
Early Education and Development. 33:1383-1394
Research Findings: In recent years, several initiatives have been put into place both federally and state-wide to expand access to high-quality early education programs. At the center of these effo...
Autor:
Yuya Kishino, Koji Matsukawa, Taisei Matsumoto, Ryota Miyazaki, Tomoko Wakabayashi, Takashi Nonaka, Fuyuki Kametani, Masato Hasegawa, Tadafumi Hashimoto, Takeshi Iwatsubo
Publikováno v:
The Journal of biological chemistry. 298(8)
Aberrant cytoplasmic accumulation of an RNA-binding protein, fused in sarcoma (FUS), characterizes the neuropathology of subtypes of ALS and frontotemporal lobar degeneration, although the effects of post-translational modifications of FUS, especiall