Výsledky vyhledávání - "Tomoko SHIGA"

Akademický článek

Comparative study on incorporation of three recombinant human α-galactosidase A drugs (agalsidases) into cultured fibroblasts and organs/tissues of Fabry mice

Autor: Takahiro Tsukimura, Tomoko Shiga, Tadayasu Togawa, Hitoshi Sakuraba

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 40, Iss , Pp 101118- (2024)

Enzyme replacement therapy (ERT) with recombinant human α-galactosidase A (α-Gal A) drugs (agalsidases) has been successfully used for treatment of Fabry disease, and three kinds of agalsidases are now available in Japan. To compare the biochemical

Externí odkaz: https://doaj.org/article/674cb07d3b214bc1942ac795d8d65842

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Akademický článek

Does administration of hydroxychloroquine/amiodarone affect the efficacy of enzyme replacement therapy for Fabry mice?

Autor: Takahiro Tsukimura, Koki Saito, Tomoko Shiga, Yasuhiro Ogawa, Hitoshi Sakuraba, Tadayasu Togawa

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 39, Iss , Pp 101079- (2024)

As a standard therapy for Fabry disease, enzyme replacement therapy (ERT) with recombinant human α-galactosidase A (α-Gal) has been successfully used, and the instructions for this drug state that “it should not be co-administrated with cationic

Externí odkaz: https://doaj.org/article/d460088d15fa46e8915fb11dcfe579ec

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Akademický článek

Delivery of Therapeutic Molecules by Transplantation of Genome-Edited Induced Pluripotent Stem Cells

Autor: Ittetsu Nakajima, Takahiro Tsukimura, Terumi Ono, Tomoko Shiga, Hiroshi Shitara, Tadayasu Togawa, Hitoshi Sakuraba, Yuichiro Miyaoka

Publikováno v: Cell Transplantation, Vol 32 (2023)

Human induced pluripotent stem cells (iPSCs) have already been used in transplantation therapies. Currently, cells from healthy people are transplanted into patients with diseases. With the rapid evolution of genome editing technology, genetic modifi

Externí odkaz: https://doaj.org/article/7b45ec56950045838750cd277a979ba4

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Akademický článek

Simultaneous self‐monitoring comparison of a supine algorithm‐equipped wrist nocturnal home blood pressure monitoring device with an upper arm device

Autor: Kazuomi Kario, Naoko Tomitani, Chie Iwashita, Tomoko Shiga, Hiroshi Kanegae

Publikováno v: The Journal of Clinical Hypertension, Vol 23, Iss 4, Pp 793-801 (2021)

Abstract A nocturnal home blood pressure (BP) monitoring device that measures nighttime BP levels accurately with less sleep disturbance is needed for the 24‐h management of hypertension. Here we conducted the first comparison study of simultaneous

Externí odkaz: https://doaj.org/article/1abf23d2f97b4921b4ec17cf0a80b823

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Akademický článek

Comparative urinary globotriaosylceramide analysis by thin-layer chromatography-immunostaining and liquid chromatography-tandem mass spectrometry in patients with Fabry disease

Autor: Tomoko Shiga, Takahiro Tsukimura, Yurie Namai, Tadayasu Togawa, Hitoshi Sakuraba

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 29, Iss , Pp 100804- (2021)

In Fabry disease, accumulation of glycolipids, predominantly globotriaosylceramide (Gb3), affects the kidneys, and nephropathy is one of the important disorders that influence the disease severity and prognosis of patients. Urinary Gb3 has been analy

Externí odkaz: https://doaj.org/article/a7c30d427599487da5536096a7c44df5

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Akademický článek

Does administration of hydroxychloroquine/amiodarone accelerate accumulation of globotriaosylceramide and globotriaosylsphingosine in Fabry mice?

Autor: Takahiro Tsukimura, Tomoko Shiga, Koki Saito, Yasuhiro Ogawa, Hitoshi Sakuraba, Tadayasu Togawa

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 28, Iss , Pp 100773- (2021)

Drug-induced lysosomal storage disease (DILSD) caused by cationic amphiphilic drugs (CADs), which exhibits toxic manifestations and pathological findings mimicking Fabry disease (α-galactosidase A deficiency), has attracted the interests of clinicia

Externí odkaz: https://doaj.org/article/6c3391292a024991816edf229bec6b30

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Akademický článek

Anti-drug antibody formation in Japanese Fabry patients following enzyme replacement therapy

Autor: Takahiro Tsukimura, Yuya Tayama, Tomoko Shiga, Kanako Hirai, Tadayasu Togawa, Hitoshi Sakuraba

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 25, Iss , Pp 100650- (2020)

Enzyme replacement therapy (ERT) for Fabry disease (deficiency of α-galactosidase A, α-Gal) with recombinant α-Gals (agalsidase alfa and agalsidase beta) is widely available and improves some of the clinical manifestations and biochemical findings

Externí odkaz: https://doaj.org/article/b92eff7f1b5d48e2800f21ec83adfb7f

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Akademický článek

Fabry disease in a Japanese population-molecular and biochemical characteristics

Autor: Hitoshi Sakuraba, Takahiro Tsukimura, Tadayasu Togawa, Toshie Tanaka, Tomoko Ohtsuka, Atsuko Sato, Tomoko Shiga, Seiji Saito, Kazuki Ohno

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 17, Iss , Pp 73-79 (2018)

We had experienced 117 Japanese Fabry patients (72 males and 45 females) from 1977 to 2006, and then we generated an improved Fabry analysis system in 2007 and have found 196 ones (95 males and 101 females) since then. In this study, we summarized th

Externí odkaz: https://doaj.org/article/de859b491ff0477fa4ed14186f6fa77a

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