Výsledky vyhledávání - "Tomoko Mutou"

In Utero Exposure to Di(n-butyl)phthalate Induces Morphological and Biochemical Changes in Rats Postpuberty

Autor: Hiroyuki Takahashi, Mitsuru Sugiyama, Masaya Motohashi, Tomoko Mutou, Hiroshi Ikegami, Shin Wakui, Yuya Okayama, Eisuke Kume, Michael F. Wempe

Publikováno v: Toxicologic Pathology. 45:526-535

Pregnant Sprague-Dawley rats were orally administered di( n-butyl)phthalate (DBP; 100 mg/kg/day) on gestation days (GD) 12 to 21. We investigated the male offspring and probed morphological alterations in Sertoli cells at 7, 9, 14, and 17 weeks of ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0091ee886ef0e00f3000dd197b27f36b
https://doi.org/10.1177/0192623317709091

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Ultrastructural immunohistochemical study of L-type amino acid transporter 1–4F2 heavy chain in tumor microvasculatures of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) induced rat bladder carcinoma

Autor: Masahiro Ikegami, Eisuke Kume, Yoshikatsu Kanai, Norio Kansaku, Hitoyuki Takahashi, Michael F. Wempe, Shin Wakui, Hitoshi Endou, Tomoko Mutou

Publikováno v: Journal of Electron Microscopy. 66:198-203

Angiogenesis is essential for tumor growth, and an enhanced vasculature supplying nutrients and oxygen might reflect malignant potential. L-type amino acid transporter 1 (LAT1/4F2hc) comprises a major nutrient transport system responsible for the Na+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205dd2a5e1f632386f01c43e35576b49
https://doi.org/10.1093/jmicro/dfx008

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Male rats exposed in utero to di(n-butyl) phthalate: Age-related changes in Leydig cell smooth endoplasmic reticulum and testicular testosterone-biosynthesis enzymes/proteins

Autor: Shin Wakui, Tomo Inomata, Masahiro Ikegami, Hiroyuki Takahashi, Masao Asari, Norio Kansaku, Tomoko Mutou, Michael F. Wempe, Masaya Motohashi

Publikováno v: Reproductive Toxicology. 59:139-146

This study investigated the age-related (i.e., weeks 5, 7, 9, 14 and 17) morphological changes of Leydig cell smooth endoplasmic reticulum (LCs-ER) and testicular testosterone biosynthesis/protein expression in rats in utero exposed to di(n-butyl) ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f5b3ccdab5c15ac451e8db74e079c1
https://doi.org/10.1016/j.reprotox.2015.12.001

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In utero-exposed di(n-butyl) phthalate induce dose dependent, age-related changes of morphology and testosterone-biosynthesis enzymes/associated proteins of Leydig cell mitochondria in rats

Autor: Hiroyuki Takahashi, Masao Asari, Yuya Okayama, Michael F. Wempe, Masahiro Ikegami, Shin Wakui, Masaya Motohashi, Tomoko Mutou, Norio Kansaku

Publikováno v: The Journal of Toxicological Sciences. 41:195-206

Female pregnant Sprague-Dawley rats were intragastrically (ig) administered di(n-butyl) phthalate (DBP) at four doses (0, 10, 50 and 100 mg/kg) during gestation days (GD) 12-21 (n = 5 per group). The age-related morphological changes of Leydig cell m

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https://doi.org/10.2131/jts.41.195

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Three-dimensional reconstruction of deferent ducts papillae in urogenital duct system of the male rat

Autor: Masahiro Ikegami, Nobutsume Ichihara, Shin Wakui, Masao Asari, Masaya Motohashi, Tomo Inomata, Tomoko Mutou, Hiroyuki Takahashi

Publikováno v: The Prostate. 75:646-652

BACKGROUND The rodent ejaculatory ducts penetrate the male accessory sex gland complex and open into the urethra, anatomically similar to humans. Although the deferent ducts papillae in rodents have been described at the distal end of deferent ducts,

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https://doi.org/10.1002/pros.22948

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Adenocarcinoma of the Ampullary Glands of the Ductus Deferens in a Sprague-Dawley Rat

Autor: Hiroyuki Takahashi, Tomo Inomata, Tomoko Mutou, Shin Wakui, Ayaka Yoshida, Masao Asari, Masaya Motohashi, Masahiro Ikegami

Publikováno v: Toxicologic Pathology. 43:593-599

Spontaneously occurring proliferative lesions of the male accessory sex glands are infrequent in various strains of rats. In rodents, the ampullary glands are embedded in the prostate. Although 2 spontaneous cases of atypical hyperplastic lesions at

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https://doi.org/10.1177/0192623314554266

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Vascular endothelial growth factor mRNA levels as a biomarker for short-termN-butyl-N-(4-hydroxybutyl) nitrosamine-induced rat bladder carcinogenesis bioassay

Autor: Hiroyuki Takahashi, Hideki Wanibuchi, Shin Wakui, Shoji Fukushima, Tomoko Mutou, Masahiro Ikegami

Publikováno v: Journal of Applied Toxicology. 35:181-190

Generically, carcinogenic effects of chemicals in bladder carcinogenesis are judged by induction of papillary or nodular (PN) hyperplasia in rats given N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) for 4 weeks and the test chemical for 22–28 weeks.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c257aecc07b6cbc4624db111405a081c
https://doi.org/10.1002/jat.3021

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Male Sprague-Dawley Rats Exposed to In Utero Di(n-butyl) Phthalate

Autor: Noriko Oyama, Shin Wakui, Masaru Shirai, Masao Asari, Tomoko Mutou, Hiroyuki Takahashi, Hiroshi Hano, Masaya Motohashi, Michael F. Wempe, Hitoshi Endou, Norio Kansaku

Publikováno v: Toxicologic Pathology. 41:984-991

When 100 mg/kg/day of di( n-butyl) phthalate (DBP) was intragastrically administered to pregnant Sprague-Dawley rats throughout gestation days 12 to 21, the male pups had similar body weights with no apparent physical differences (e.g., litter size,

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https://doi.org/10.1177/0192623312474725

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Nuclear Morphometric Analysis of Leydig Cells of Male Pubertal Rats Exposed In Utero to Di(n-butyl) Phthalate

Autor: Masao Asari, Tomoo Inomata, Hitoshi Endou, Takemi Satoh, Michael F. Wempe, Masaya Motohashi, Shin Wakui, Hiroyuki Takahashi, Masaru Shirai, Tomoko Mutou

Publikováno v: Journal of Toxicologic Pathology. 26:439-446

We recently reported that prenatal rat exposure to di(n-butyl) phthalate (DBP) induced Leydig cell (LC) hyperplasia after nine weeks (wks) of age, yet the number of LCs was similar to that of the vehicle group until seven weeks. Nuclear pleomorphism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::328d244794ceb442f944fe92d7330fd0
https://doi.org/10.1293/tox.2013-0031

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In utero-exposed di(n-butyl) phthalate induce dose dependent, age-related changes of morphology and testosterone-biosynthesis enzymes/associated proteins of Leydig cell mitochondria in rats

Autor: Masaya, Motohashi, Michael F, Wempe, Tomoko, Mutou, Yuya, Okayama, Norio, Kansaku, Hiroyuki, Takahashi, Masahiro, Ikegami, Masao, Asari, Shin, Wakui

Publikováno v: The Journal of toxicological sciences. 41(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::05bf8a21117e6fd0015b2c25eb096125
https://pubmed.ncbi.nlm.nih.gov/26961603

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