Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Tomoko Isosaka"'
Autor:
Tomohiko Matsuo, Tomoko Isosaka, Yuichiro Hayashi, Lijun Tang, Akihiro Doi, Aiko Yasuda, Mikio Hayashi, Chia-Ying Lee, Liqin Cao, Natsumaro Kutsuna, Sachihiro Matsunaga, Takeshi Matsuda, Ikuko Yao, Mitsuyoshi Setou, Dai Kanagawa, Koichiro Higasa, Masahito Ikawa, Qinghua Liu, Reiko Kobayakawa, Ko Kobayakawa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Matsuo et al. report that thiazoline-related innate fear-eliciting compounds activate the spinal trigeminal nucleus (Sp5) and the nucleus of the solitary tract (NTS) via vagal/trigeminal TRPA1 to induce robust physiological alterations, enabling long
Externí odkaz:
https://doaj.org/article/11cd2c695fc1408dbc40c83693c9f503
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Matsuo, Isosaka, et al report that innate fear, but not learned fear, in mice results in systemic hypothermia/hypometabolism and suppressed aerobic metabolism, which enables survival in hypoxic environments. They demonstrate that this process is orch
Externí odkaz:
https://doaj.org/article/bfa63aa7e10d4f18858074c827e1d90a
Autor:
Hajime Yamanaka, Yu Takata, Hiroshi Nakagawa, Tomoko Isosaka-Yamanaka, Toshihide Yamashita, Masahiko Takada
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252023 (2021)
Repetitive transcranial magnetic stimulation (rTMS) targeting the primary motor cortex (MI) is expected to provide a therapeutic impact on spinal cord injury (SCI). On the other hand, treatment with antibody against repulsive guidance molecule-a (RGM
Externí odkaz:
https://doaj.org/article/aa4cd4de25734ba28309b779eeec737b
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Communications Biology
Communications Biology
Innate fear intimately connects to the life preservation in crises, although this relationships is not fully understood. Here, we report that presentation of a supernormal innate fear inducer 2-methyl-2-thiazoline (2MT), but not learned fear stimuli,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c0795824c67cf8dbc415cb9e7c24c4
https://doi.org/10.1038/s42003-020-01629-2
https://doi.org/10.1038/s42003-020-01629-2
Autor:
Yuichiro Hayashi, Sachihiro Matsunaga, Mikio Hayashi, Tomoko Isosaka, Lijun Tang, Mitsuyoshi Setou, Dai Kanagawa, Tomohiko Matsuo, Reiko Kobayakawa, Chia-Ying Lee, Aiko Yasuda, Qinghua Liu, Liqin Cao, Koichiro Higasa, Ikuko Yao, Natsumaro Kutsuna, Takeshi Matsuda, Ko Kobayakawa, Masahito Ikawa, Akihiro Doi
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Thiazoline-related innate fear-eliciting compounds (tFOs) orchestrate hypothermia, hypometabolism, and anti-hypoxia, which enable survival in lethal hypoxic conditions. Here, we show that most of these effects are severely attenuated in transient rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb83667ed7408503cc17a47e3b29aff
https://pubmed.ncbi.nlm.nih.gov/33824316
https://pubmed.ncbi.nlm.nih.gov/33824316
SummaryTherapeutic hypothermia protects the brain after cardiopulmonary arrest. Innate fear has evolved to orchestrate protective effects in life-threatening situations. Thus, strong fear perception may induce a specialized life-protective metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5911dd4fad13f9adb25a60e832c3389d
https://doi.org/10.1101/2020.05.17.100933
https://doi.org/10.1101/2020.05.17.100933
Autor:
Masahiko Takada, Tomoko Isosaka-Yamanaka, Hajime Yamanaka, Yu Takata, Toshihide Yamashita, Hiroshi Nakagawa
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252023 (2021)
PLoS ONE
PLoS ONE
Repetitive transcranial magnetic stimulation (rTMS) targeting the primary motor cortex (MI) is expected to provide a therapeutic impact on spinal cord injury (SCI). On the other hand, treatment with antibody against repulsive guidance molecule-a (RGM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f12ea71524c4a024f630c183ee4097
https://doi.org/10.1371/journal.pone.0252023
https://doi.org/10.1371/journal.pone.0252023
Autor:
Tomoko Isosaka, Shigeki Yuasa
Publikováno v:
NeuroReport. 21:554-558
Contextual fear memory is attenuated by re-exposure of animals to a context alone without pairing it with an unconditioned stimulus, and this phenomenon is referred to as fear extinction. In this study we demonstrated that stereotaxic injection of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01857af4260652745f90bd318f9f4dae
https://doi.org/10.1097/wnr.0b013e328338ba4f
https://doi.org/10.1097/wnr.0b013e328338ba4f
Publikováno v:
NeuroReport. 20:1461-1465
Contextual fear memory is attenuated by reexposure of animals to a context alone without pairing it with an unconditioned stimulus, a phenomenon referred to as fear extinction. Here, we report that Fyn tyrosine kinase in the hippocampus is involved i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740bc3cd414b9abba0021b528750086f
https://doi.org/10.1097/wnr.0b013e32833203a8
https://doi.org/10.1097/wnr.0b013e32833203a8
Autor:
Kotaro Hattori, Shun Hamada, Tomoko Isosaka, Takeshi Yagi, Hiroshi Fukuzako, Yoji Murata, Tomo Hashiguchi, Shigeki Yuasa
Publikováno v:
Psychiatry Research. 168:119-128
Fyn, a Src-family kinase, is highly expressed in brain tissue and blood cells. In the mouse brain, Fyn participates in brain development, synaptic transmission through the phosphorylation of N-methyl-d-aspartate (NMDA) receptor subunits, and the regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b174a77f3780d90743ea32788636692
https://doi.org/10.1016/j.psychres.2008.04.014
https://doi.org/10.1016/j.psychres.2008.04.014