Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Tomoko Ichisaka"'
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94735 (2014)
It has been shown that DNA demethylation plays a pivotal role in the generation of induced pluripotent stem (iPS) cells. However, the underlying mechanism of this action is still unclear. Previous reports indicated that activation-induced cytidine de
Externí odkaz:
https://doaj.org/article/faa5d9106acf4166af5736277fec7865
Autor:
Kumiko A Iwabuchi, Tatsuya Yamakawa, Yoshiko Sato, Tomoko Ichisaka, Kazutoshi Takahashi, Keisuke Okita, Shinya Yamanaka
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20461 (2011)
The principal factors that lead to proliferation and pluripotency in embryonic stem cells (ESCs) have been vigorously investigated. However, the global network of factors and their full signaling cascade is still unclear. In this study, we found that
Externí odkaz:
https://doaj.org/article/a6f2fc3d395d45a6b849ba409d79c6fb
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8067 (2009)
BACKGROUND: For therapeutic usage of induced Pluripotent Stem (iPS) cells, to accomplish xeno-free culture is critical. Previous reports have shown that human embryonic stem (ES) cells can be maintained in feeder-free condition. However, absence of f
Externí odkaz:
https://doaj.org/article/1424c4d5f4be4882ba390d278ea2f911
Autor:
Shinsuke Yoshida, Tomoaki M. Kato, Yoshiko Sato, Masafumi Umekage, Tomoko Ichisaka, Masayoshi Tsukahara, Naoko Takasu, Shinya Yamanaka
Publikováno v:
Med. 4:51-66.e10
Human induced pluripotent stem cells (iPSCs) are expected to be useful for regenerative medicine for many diseases. Many researchers have focused on and enabled the generation of differentiated cells or tissue-like structures, including organoids, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97f7b2ae7f4a67ec5103f0ed4041f08
https://doi.org/10.1016/j.medj.2022.10.003
https://doi.org/10.1016/j.medj.2022.10.003
Autor:
Shinya Yamanaka, Yuka Sawamura, Akira Watanabe, Michiyo Koyanagi-Aoi, Keisuke Okita, Asuka Morizane, Hisashi Noma, Naoki Amano, Mari Ohnuki, Yasuhiro Yamada, Kazutoshi Takahashi, Tomoko Ichisaka, Yoshiko Sato, Tosiya Sato, Ito Teramoto, Jun Takahashi, Megumi Narita
Publikováno v:
Proceedings of the National Academy of Sciences. 110:20569-20574
We examined the gene expression and DNA methylation of 49 human induced pluripotent stem cells (hiPSCs) and 10 human embryonic stem cells and found overlapped variations in gene expression and DNA methylation in the two types of human pluripotent ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54c22f7f18c453e013da5108bc81080
https://doi.org/10.1073/pnas.1319061110
https://doi.org/10.1073/pnas.1319061110
Autor:
Kenji Osafune, Yasunori Sato, Fumiyo Kitaoka, Sumiko Inoue, Kazuwa Nakao, Yasuhiro Yamada, Hatasu Kobayashi, Satoshi Matsui, Taro Toyoda, Takuya Yamamoto, Norio Matsuura, Masakatsu Sone, Akira Watanabe, Shin Ichi Mae, Toshikazu Araoka, Tatsutoshi Nakahata, Kazutoshi Takahashi, Eri Muso, Naoki Amano, Akio Koizumi, Shinya Yamanaka, Tetsuhiko Yasuno, Atsushi Fukatsu, Tomohiro Numata, Yasuo Mori, Naoya Kondo, Sayaka Arai, Yoshifumi Ubara, Daisuke Taura, Tomonaga Ameku, Isao Asaka, Fumihiko Shiota, Tomoko Ichisaka, Masahiro Nakamura
Publikováno v:
Scientific Reports
Cardiovascular complications are the leading cause of death in autosomal dominant polycystic kidney disease (ADPKD), and intracranial aneurysm (ICA) causing subarachnoid hemorrhage is among the most serious complications. The diagnostic and therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f03ea0bf264994cbffb0d1660ea95e4
http://europepmc.org/articles/PMC4945931
http://europepmc.org/articles/PMC4945931
Publikováno v:
Molecular and cellular biology. 31(21):4366-4378
Many transcription factors and DNA binding proteins play essential roles in the development of organs in which they are highly and/or specifically expressed. Embryonic stem cell (ESC)-associated transcript 15-1 (ECAT15-1) and ECAT15-2, also known as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02960959fbcf0c939ac0cae02304d2f1
http://hdl.handle.net/2433/152301
http://hdl.handle.net/2433/152301
Autor:
Shinya Yamanaka, Kanako Nakao-Wakabayashi, Naoki Okamoto, Naomi Kitamura, Masayuki Komada, Je-Young Ryu, Kimitoshi Denda, Tomoko Ichisaka, Yoh-ichi Tagawa
Publikováno v:
Journal of Biological Chemistry. 286:28802-28810
The complete mechanism of labor induction in eutherian mammals remains unclear. Although important roles for the fetus and placenta in triggering labor have been proposed, no gene has been shown to be required in the fetus/placenta for labor inductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3ea816ddb51345bd9e020a44a8ec45
https://doi.org/10.1074/jbc.m111.258160
https://doi.org/10.1074/jbc.m111.258160
Publikováno v:
Proceedings of the National Academy of Sciences. 107(32):14152-14157
Induced pluripotent stem cells (iPSCs) are generated from mouse and human fibroblasts by the introduction of three transcription factors: Oct3/4, Sox2, and Klf4. The proto-oncogene product c-Myc markedly promotes iPSC generation, but also increases t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7330392b42dcd87b0271508be64b922
http://hdl.handle.net/2433/123272
http://hdl.handle.net/2433/123272
Autor:
Naritaka Tamaoki, Tomoko Takeda-Kawaguchi, Tomoko Ichisaka, Toshiyuki Shibata, Kazuki Iida, Hitomi Aoki, Shinya Yamanaka, Tetsu Tanaka, Ken-ichi Tezuka, Kazutoshi Takahashi, Takahiro Kunisada
Publikováno v:
Journal of Dental Research. 89:773-778
Defined sets of transcriptional factors can reprogram human somatic cells to induced pluripotent stem (iPS) cells. However, many types of human cells are not easily accessible to minimally invasive procedures. Here we evaluated dental pulp cells (DPC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45832c02e096f2bff4ce91c9790d98bc
https://doi.org/10.1177/0022034510366846
https://doi.org/10.1177/0022034510366846