Výsledky vyhledávání - "Tomoko Horisawa"

Akademický článek

Blonanserin extensively occupies rat dopamine D3 receptors at antipsychotic dose range

Autor: Satoko Baba, Takeshi Enomoto, Tomoko Horisawa, Takashi Hashimoto, Michiko Ono

Publikováno v: Journal of Pharmacological Sciences, Vol 127, Iss 3, Pp 326-331 (2015)

Antagonism of the dopamine D3 receptor has been hypothesized to be beneficial for schizophrenia cognitive deficits, negative symptoms and extrapyramidal symptoms. However, recent animal and human studies have shown that most antipsychotics do not occ

Externí odkaz: https://doaj.org/article/d26f7a87f9fb4fddbde7da8c50bd6a1d

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Discovery of SMP-304, a novel benzylpiperidine derivative with serotonin transporter inhibitory activity and 5-HT1A weak partial agonistic activity showing the antidepressant-like effect

Autor: Hitomi Oki, Satoko Baba, Naoya Kinomura, Tomoko Horisawa, Yuji Matsumoto, Shuji Masumoto, Toru Kodo, Hidefumi Yoshinaga, Kazuki Yabuuchi, Kenji Matsumoto, Koji Koyama, Taro Kato

Publikováno v: Bioorganic & Medicinal Chemistry. 25:293-304

We report the discovery of a novel benzylpiperidine derivative with serotonin transporter (SERT) inhibitory activity and 5-HT1A receptor weak partial agonistic activity showing the antidepressant-like effect. The 3-methoxyphenyl group and the pheneth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ba769b17a416f9ae21de763c79ea557
https://doi.org/10.1016/j.bmc.2016.10.034

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Binding of lurasidone, a novel antipsychotic, to rat 5-HT7 receptor: Analysis by [3H]SB-269970 autoradiography

Autor: Mutsuo Taiji, Tadashi Ishibashi, Michiko Ono, Takeo Ishiyama, Tomoko Horisawa

Publikováno v: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 40:132-137

Lurasidone is a novel antipsychotic agent with high affinity for dopamine D(2) and serotonin 5-HT(7), 5-HT(2A), and 5-HT(1A) receptors. We previously reported that in addition to its antipsychotic action, lurasidone shows beneficial effects on mood a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3714cc62cba599527f17caaa375536e0
https://doi.org/10.1016/j.pnpbp.2012.08.005

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Structural insight into receptor-selectivity for lurasidone

Autor: Tomoko Horisawa, Kumiko Tokuda, Osamu Ichikawa, Kazuhiko Okazaki, Hiroyuki Nakahira, Kazuto Yamazaki, Megumi Maruyama, Ryu Nagata

Publikováno v: Neurochemistry International. 61:1133-1143

Lurasidone is a novel antipsychotic agent with high affinity for dopamine D(2), 5-hydroxyltryptamine 5-HT(2A), and 5-HT(7) receptors. Lurasidone has negligible affinity for histamine H(1) and muscarinic M(1) receptors, which are thought to contribute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e167b39123352b2e47c94d2c8dc8a1c1
https://doi.org/10.1016/j.neuint.2012.08.005

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Evaluation of dopamine D2/D3 and serotonin 5-HT2A receptor occupancy for a novel antipsychotic, lurasidone, in conscious common marmosets using small-animal positron emission tomography

Autor: Hiroshi Mizuma, Hirotaka Onoe, Tomoko Horisawa, Shunsuke Nakazawa, Akihiro Kawasaki, Naohiro Nishimura, Hisashi Doi, Chihiro Yokoyama

Publikováno v: Psychopharmacology. 225:329-339

Lurasidone is a novel antipsychotic drug with potent binding affinity for dopamine D2 and serotonin (5-hydroxytryptamine, 5-HT)2A, 5-HT7, and 5-HT1A receptors. Previous pharmacological studies have revealed that lurasidone exhibits a preferable profi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a16512c8981a7c65ca63955cd30fafec
https://doi.org/10.1007/s00213-012-2815-9

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The role of 5-HT7 receptor antagonism in the amelioration of MK-801-induced learning and memory deficits by the novel atypical antipsychotic drug lurasidone

Autor: Satoko Toma, Tomoko Horisawa, Hiroyuki Nishikawa, Atsushi Ikeda, Masakuni Horiguchi, Mutsuo Taiji, Michiko Ono, Takeo Ishiyama

Publikováno v: Behavioural brain research. 244

Lurasidone is a novel atypical antipsychotic with high affinity for dopamine D2, serotonin 5-HT7 and 5-HT2A receptors. We previously reported that lurasidone and the selective 5-HT7 receptor antagonist, SB-656104-A improved learning and memory defici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41919c57538330623b5f265b0e3d2f12
https://pubmed.ncbi.nlm.nih.gov/23376699

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Evaluation of dopamine D₂/D₃ and serotonin 5-HT₂A receptor occupancy for a novel antipsychotic, lurasidone, in conscious common marmosets using small-animal positron emission tomography

Autor: Shunsuke, Nakazawa, Chihiro, Yokoyama, Naohiro, Nishimura, Tomoko, Horisawa, Akihiro, Kawasaki, Hiroshi, Mizuma, Hisashi, Doi, Hirotaka, Onoe

Publikováno v: Psychopharmacology. 225(2)

Lurasidone is a novel antipsychotic drug with potent binding affinity for dopamine D(2) and serotonin (5-hydroxytryptamine, 5-HT)(2A), 5-HT(7), and 5-HT(1A) receptors. Previous pharmacological studies have revealed that lurasidone exhibits a preferab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::22305b1f914aa0973fc16e5faa2f2bab
https://pubmed.ncbi.nlm.nih.gov/22868411

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The effects of selective antagonists of serotonin 5-HT7 and 5-HT1A receptors on MK-801-induced impairment of learning and memory in the passive avoidance and Morris water maze tests in rats: mechanistic implications for the beneficial effects of the novel atypical antipsychotic lurasidone

Autor: Takeshi Enomoto, Satoko Toma, Takeo Ishiyama, Mutsuo Taiji, Hiroyuki Nishikawa, Tomoko Horisawa, Tadashi Ishibashi

Publikováno v: Behavioural brain research. 220(1)

We have previously reported that lurasidone, a novel atypical antipsychotic with potent serotonin 5-HT(7) antagonist and 5-HT(1A) partial agonist activities, is superior to other antipsychotics in improving the N-methyl-D-aspartate (NMDA) receptor an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7bb63fa41029de87cd07749c632e256
https://pubmed.ncbi.nlm.nih.gov/21277905

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Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity

Autor: Satoko Toma, Yoko Ueda, Yukihiro Ohno, Kumiko Tokuda, Hitomi Oki, Kenji Matsumoto, Takeo Ishiyama, Tomoko Horisawa, Hiroyuki Nishikawa, Tadashi Ishibashi, Mitsutaka Nakamura, Norihiko Tanno, Masaaki Ogasa, Ikutaro Saji, Akira Ito, Rie Tagashira

Publikováno v: The Journal of pharmacology and experimental therapeutics. 334(1)

Lurasidone [(3aR,4S,7R,7aS)-2-[(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-ylmethyl]cyclohexylmethyl]hexahydro-4,7-methano-2H-isoindole-1,3-dione hydrochloride; SM-13496] is an azapirone derivative and a novel antipsychotic candidate. The objec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b1922595812986a6a0070c9ba11828
https://pubmed.ncbi.nlm.nih.gov/20404009

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