Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Tomoko Hirohashi"'
Autor:
Konstantin Penkov, Igor Bondarenko, Daria Viktorovna Saenko, Yaroslav Kulyaba, Jun Guo, Yi Gong, Noboru Yamamoto, Yevhen Stepanovych Hotko, Vasyl Boyko, Natalya Vladimirovna Fadeeva, Grygorii Mykolaiovych Ursol, Hee Kyung Ahn, Nikolay Viktorovich Kislov, Chia-I Shen, Craig Davis, Karey Kowalski, Elisabete Michelon, Dmitri Pavlov, Tomoko Hirohashi, Byoung Chul Cho
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 16 (2024)
Background: Sasanlimab (PF-06801591), a humanized immunoglobulin G4 monoclonal antibody, binds to programmed cell death protein-1 (PD-1), preventing ligand (PD-L1) interaction. Objectives: To evaluate pharmacokinetics (PK), safety, tolerability, and
Externí odkaz:
https://doaj.org/article/a3ad25bc9da747acad6405e92fd609c8
Autor:
Tomoko Hirohashi, Joseph Thaddeus Beck, Jessica Dreger McDermott, James L. Abbruzzese, Toshihiko Doi, Kim Ingram, Ruifeng Li, Vivek Subbiah
Publikováno v:
Journal of Clinical Oncology. 41:TPS743-TPS743
TPS743 Background: Tumor-associated macrophage kinases (TAMK) are expressed on tumor cells during malignant transformation. Inhibition of AXL and MERTK, members of the TAMK family, may lower the immune activation threshold and promote antitumor immun
Autor:
Jessica Dreger McDermott, Vivek Subbiah, Joseph Thaddeus Beck, Toshihiko Doi, Tomoko Hirohashi, Kim Ingram, Ruifeng Li, James L. Abbruzzese
Publikováno v:
Journal of Clinical Oncology. 41:TPS270-TPS270
TPS270 Background: Inhibition of Mer Proto-oncogene tyrosine kinase (MERTK) and AXL may lower the threshold for immune activation thereby promoting anti-tumor activity. PF-07265807 (ARRY-067) is a selective small-molecule inhibitor of the tumor-assoc
Autor:
Haruhiko Banno, Akiko Morinaga, Akira Shimizu, Naoto Takahashi, Haruhisa Inoue, Makiko Nagai, Yuishin Izumi, Keiko Imamura, Satoshi Morita, Ryuji Uozumi, Takafumi Ikeda, Ritsuko Hanajima, Takashi Ayaki, Tomoko Hirohashi, Naohiro Egawa, Koji Fujita, Yosuke Fujii, Ryosuke Takahashi, Kazutoshi Nishiyama, Yasuhiro Watanabe, Ryosuke Oki
Publikováno v:
BMJ Open
IntroductionAmyotrophic lateral sclerosis (ALS) is a progressive and severe neurodegenerative disease caused by motor neuron death. There have as yet been no fundamental curative medicines, and the development of a medicine for ALS is urgently requir
Autor:
Satoshi Morita, Makiko Nagai, Ryosuke Takahashi, Naohiro Egawa, Keiko Imamura, Ritsuko Hanajima, Haruhisa Inoue, Yosuke Fujii, Takashi Ayaki, Yuishin Izumi, Tomoko Hirohashi, Akiko Morinaga, Koji Fujita, Kazutoshi Nishiyama, Yasuhiro Watanabe, Ryosuke Oki, Ryuji Uozumi
Publikováno v:
Journal of the Neurological Sciences. 429:119418
Autor:
Tomoko Hirohashi, Martin Gutierrez, Colleen Oliver, Sai-Hong Ignatius Ou, James L. Abbruzzese, Jessica D. McDermott, Lance Wollenberg, Kim Ingram, Mark M. Awad, Adil Daud, Vivek Subbiah, Derek Smith
Publikováno v:
Journal of Clinical Oncology. 39:TPS2671-TPS2671
TPS2671 Background: MERTK is a receptor tyrosine kinase from the tumor-associated macrophage kinase (TAMK) family that regulates key aspects of immune homeostasis and responses to infection. MERTK inhibition may lower the threshold for immune activat
Autor:
Toshihiko Doi, Yosuke Fujii, Kiyotaka Yoh, Kyung-Hun Lee, Atsushi Ohtsu, Tomoko Hirohashi, Yung-Jue Bang, J. A. Williams, Akiyuki Suzuki, Tae Yong Kim, Corrado Gallo Stampino, Tae Min Kim, Masafumi Ikeda
Publikováno v:
Cancer Medicine
Preclinical studies suggest that ALK‐1 signaling mediates a complementary angiogenesis pathway activated upon development of resistance to vascular endothelial growth factor (VEGF)‐targeted therapies. Inhibition of ALK‐1 signaling may lead to d
Autor:
TOMOKO HIROHASHI1, KIYOKO IGARASHI2, MASAAKI ABE1, MASAHIRO MAEDA3, OKIO HINO1 ohino@juntendo.ac.jp
Publikováno v:
Molecular & Clinical Oncology. 2014, Vol. 2 Issue 1, p26-30. 5p.
Autor:
Keiko Imamura, Yuishin Izumi, Haruhiko Banno, Ryuji Uozumi, Satoshi Morita, Naohiro Egawa, Takashi Ayaki, Makiko Nagai, Kazutoshi Nishiyama, Yasuhiro Watanabe, Ritsuko Hanajima, Ryosuke Oki, Koji Fujita, Naoto Takahashi, Takafumi Ikeda, Akira Shimizu, Akiko Morinaga, Tomoko Hirohashi, Yosuke Fujii, Ryosuke Takahashi
Publikováno v:
BMJ Open; Dec2019, Vol. 9 Issue 12, p1-7, 7p
Publikováno v:
Molecular and Clinical Oncology. 2:26-30
The early diagnosis of mesothelioma, an aggressive malignant tumor, is considered to be important for prognosis. X-ray is commonly used for the assessment of a mass in a population exhibiting a risk factor. However, there are currently no available s