Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Tomoko Hirama"'
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 7, Pp 1399-1405 (2006)
To obtain a panel of monoclonal antibodies (MAbs) to study the folding and conformation of the low density lipoprotein receptor (LDLr), we have generated hybridomas from LDLr-deficient mice that had been immunized with the extracellular domain of the
Externí odkaz:
https://doaj.org/article/7e144b8dcc4b4e2b86f77f0ee838df35
Autor:
Ali Riazi, Philippa C R Strong, Russell Coleman, Wangxue Chen, Tomoko Hirama, Henk van Faassen, Matthew Henry, Susan M Logan, Christine M Szymanski, Roger Mackenzie, Mehdi Arbabi Ghahroudi
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83928 (2013)
Campylobacter jejuni is the leading cause of bacterial foodborne illness in the world, with symptoms ranging from acute diarrhea to severe neurological disorders. Contaminated poultry meat is a major source of C. jejuni infection, and therefore, stra
Externí odkaz:
https://doaj.org/article/12ad248f0170417794ff4b59f54cd3f8
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e28218 (2011)
The extreme pH and protease-rich environment of the upper gastrointestinal tract is a major obstacle facing orally-administered protein therapeutics, including antibodies. Through protein engineering, several Clostridium difficile toxin A-specific he
Externí odkaz:
https://doaj.org/article/b24e4679d3a64b85b9233518ddbe5e16
Autor:
Dae Young Kim, Rebecca To, Henk van Faassen, Joseph D. Schrag, Jamshid Tanha, Mary Alice Hefford, Wen Ding, Roger Mackenzie, Nadereh St-Amant, Yan Luo, John F. Kelly, Tomoko Hirama, Hiba Kandalaft
Publikováno v:
mAbs
We set out to gain deeper insight into the potential of antibody light chain variable domains (VLs) as immunotherapeutics. To this end, we generated a naïve human VL phage display library and, by using a method previously shown to select for non-agg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ac06ab5ef9d4d96287a83a87816986
https://doi.org/10.4161/mabs.26844
https://doi.org/10.4161/mabs.26844
Autor:
Lai-Xi Wang, Cory L. Brooks, Hans Schreiber, C.R. MacKenzie, Svetlana N. Borisova, Mark Okon, Peter Kufer, Stephen V. Evans, Tomoko Hirama, A Schietinger
Publikováno v:
Proceedings of the National Academy of Sciences. 107:10056-10061
Aberrant glycosylation and the overexpression of certain carbohydrate moieties is a consistent feature of cancers, and tumor-associated oligosaccharides are actively investigated as targets for immunotherapy. One of the most common aberrations in gly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015986a3f5489290093581a40f56d44a
https://doi.org/10.1073/pnas.0915176107
https://doi.org/10.1073/pnas.0915176107
Autor:
Sven Müller-Loennies, L Brade, C.R. MacKenzie, S.N. Borisova, Helmut Brade, Stephen V. Evans, Paul Kosma, Cory L. Brooks, Tomoko Hirama
Publikováno v:
Biochemistry. 49:570-581
In order to explore monoclonal antibody recognition carbohydrate antigens, several structures from two monoclonal antibodies directed against carbohydrate epitopes derived from chlamydial LPS have been solved to high resolution. With the exception of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3f8752fde4069bc2497e9093ec6e14
https://doi.org/10.1021/bi9011308
https://doi.org/10.1021/bi9011308
Autor:
Shokouh Makvandi-Nejad, Tomoko Hirama, Wenju Zheng, Ted Fjällman, Matthew J. Henry, Wangxue Chen, Jianbing Zhang, Rhonda KuoLee, Shenghua Li
Publikováno v:
Molecular Immunology. 46:1718-1726
An efficient immunization system is essential for the development of mucosal vaccine. Cholera toxin (CT) and Escherichia coli heat labile toxin (LT) are among the strongest adjuvants tested in experimental animals but their use in humans has been hin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6cfc61ed6caf861ad90997768bad0e
https://doi.org/10.1016/j.molimm.2009.02.007
https://doi.org/10.1016/j.molimm.2009.02.007
Autor:
Mehdi Arbabi-Ghahroudi, N. Gaudette, Tomoko Hirama, Rebecca To, Jamshid Tanha, Wen Ding, R. MacKenzie
Publikováno v:
Protein Engineering Design and Selection. 22:59-66
When panned with a transient heat denaturation approach against target enzymes, a human V(H) (antibody heavy chain variable domain) phage display library yielded V(H)s with composite characteristics of binding, non-aggregation and reversible thermal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc4280251ab9e0e055c5dfcb528cbdb
https://doi.org/10.1093/protein/gzn071
https://doi.org/10.1093/protein/gzn071
Autor:
Ping Xu, Feng Ni, Roger MacKenzie, Tomoko Hirama, Ping Wang, Mehdi Arbabi-Ghahroudi, Jamshid Tanha, Rebecca To
Publikováno v:
Journal of Biological Chemistry. 280:41395-41403
Human V(H) domains are promising molecules in applications involving antibodies, in particular, immunotherapy because of their human origin. However, they are, in general, prone to aggregation. Therefore, various strategies have been employed to acqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9de1beea622a3095084ba7288ec0ce5
https://doi.org/10.1074/jbc.m509900200
https://doi.org/10.1074/jbc.m509900200
Autor:
Blair A. Harrison, Eleonora Altman, Roger MacKenzie, Rebecca To, Tomoko Hirama, Vandana Chandan
Publikováno v:
Biochemistry and Cell Biology. 83:589-596
The cell envelope of Helicobacter pylori contains lipopolysaccharide (LPS), the O-chain of which expresses type 2 Lexand Leyblood group antigens, which mimic human gastric mucosal cell-surface glycoconjugates and may contribute to the survival of H.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0619a0ac42ff8bf639e351b3fc813e96
https://doi.org/10.1139/o05-052
https://doi.org/10.1139/o05-052