Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Tomoko HASUNUMA"'
Autor:
Naoyuki Otani, Hirokazu Wakuda, Hiromitsu Imai, Masae Kuranari, Yasuyuki Ishii, Yuko Ito, Akihiro Okubo, Osamu Ogawa, Kenji Takeda, Tetsuji Ohyama, Tomoko Hasunuma, Naoto Uemura
Publikováno v:
Clinical and Translational Science, Vol 12, Iss 5, Pp 513-518 (2019)
This study evaluated the utility of combination of digoxin (0.25 mg) and rosuvastatin (5 mg) as a new transporter (P‐glycoprotein/breast cancer resistance protein/organic anion‐transporting polypeptide (OATP)1B1/OATP1B3) probe cocktail (Oita comb
Externí odkaz:
https://doaj.org/article/fae327b93c584f7180015f4fb07afd0b
Autor:
Takashi Moritoyo, Tomoko Hasunuma, Kazuhiro Harada, Tomonori Tateishi, Makoto Watanabe, Tsutomu Kotegawa, Masahiro Nagai, Yuji Kumagai, Tomomichi Fujitani, Takahumi Okura, Tomikazu Fukuoka, Kenichi Miyoshi, Bunzo Matsuura, Shinya Furukawa, Tomoe Kobori, Hiroyoko Moritoyo, Noriko Nishikawa, Tomoaki Tsujii, Hirotaka Iwaki, Masahiko Nakamura, Satoshi Makino, Kei Ohnuma, Koichiro Yuji, Megumi Hashimoto, Masaru Takasu, Yutaka Hashizume, Koji You, Tomoko Matsumura, Yuji Tanaka, Nahoko Matsumoto, Junichi Nakamura, Jun Miura, Tadao Akizawa, Kozo Kitazawa, Takanori Shibata, Aki Kuroki, Hirokazu Honda, Masanori Mukai, Kyoichi Ohashi, Takuya Morimoto, Hiromitsu Imai, Toshiaki Okudaira, Fuminori Sato, Junko Imanaga, Katsuhiro Tanaka, Masahiro Nomoto
Publikováno v:
Journal of Pharmacological Sciences, Vol 119, Iss 4, Pp 324-329 (2012)
The effect of renal impairment on the pharmacokinetics of a single oral dose of memantine (10 mg) was determined in Japanese subjects. Subjects were assigned to four groups based on baseline creatinine clearance (CLCR): normal renal function (> 80 mL
Externí odkaz:
https://doaj.org/article/30a4c5ce385f43e8a9e2bb919dd32a73
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139873 (2015)
Luseogliflozin is a selective sodium glucose co-transporter 2 (SGLT2) inhibitor. To evaluate the cardiac safety of luseogliflozin, a thorough QT/QTc study was conducted in healthy Japanese subjects. The effects of moxifloxacin on QT prolongation in J
Externí odkaz:
https://doaj.org/article/092ec9bd16d148e1a35416e958816719
Autor:
Wataru Akahata, Takashi Sekida, Takuto Nogimori, Hirotaka Ode, Tomokazu Tamura, Kaoru Kono, Yoko Kazami, Ayaka Washizaki, Yuji Masuta, Rigel Suzuki, Kenta Matsuda, Mai Komori, Amber Morey, Keiko Ishimoto, Misako Nakata, Tomoko Hasunuma, Takasuke Fukuhara, Yasumasa Iwatani, Takuya Yamamoto, Jonathan F Smith, Nobuaki Sato
SummaryBACKGROUNDVLPCOV-01 is a lipid nanoparticle-encapsulated self-amplifying RNA (saRNA) vaccine that expresses a membrane-anchored receptor-binding domain (RBD) derived from the SARS-CoV-2 spike protein.METHODSA phase 1 study of VLPCOV-01 was con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c6b1fe5342cf73a4f57c79b7f62a5d9
https://doi.org/10.2139/ssrn.4309025
https://doi.org/10.2139/ssrn.4309025
Autor:
Tetsuya Kawakita, Tomoko Hasunuma, David A Hollander, Paul J Gomes, Hiroshi Fujishima, Takuro Sekiya
Publikováno v:
Ocular Immunology and Inflammation. 29:1621-1626
This study evaluated the efficacy and safety of once-daily Alcaftadine 0.25% (AGN-229666) for prevention of signs and symptoms of Japanese cedar-pollen allergic conjunctivitis. This was a single-ce...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5ef9152582c43d6931e01341299432
https://doi.org/10.1080/09273948.2020.1760309
https://doi.org/10.1080/09273948.2020.1760309
Autor:
Atsushi Nakajima, Sonoko Ishizaki, Kazuki Matsuda, Shinsuke Kurosu, Shinya Taniguchi, Per‐Göran Gillberg, Jan P Mattsson, Tomoko Hasunuma, Michael Camilleri
Publikováno v:
Journal of gastroenterology and hepatology. 37(5)
Elobixibat is a locally acting inhibitor of the ileal bile acid transporter. We compared bile acid metabolism between healthy subjects and patients with chronic constipation and assessed changes in the bile acid profile after elobixibat administratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116ce6cbd7b84303c1e24a21405de009
https://pubmed.ncbi.nlm.nih.gov/35168298
https://pubmed.ncbi.nlm.nih.gov/35168298
Publikováno v:
Clinical Drug Investigation
Background and Objective An increased incidence in bleeding events has been reported in Western elderly patients receiving prasugrel. Therefore, doses in Japanese elderly subjects need to be carefully determined. We assessed the pharmacokinetic and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b196fdda6c43a7ea7ea7a70fac0783
https://doi.org/10.1007/s40261-017-0525-0
https://doi.org/10.1007/s40261-017-0525-0
Autor:
Kazuhiro Yokota, Tomoko Hasunuma, Hiroshi Nakatani, Mayumi Matsuda, Toshihide Mimura, Shinichi Kawai, Hisashi Noma, Yoshitake Takebayashi, Noritsune Kozu, Yoshimi Aizaki, Yu Funakubo Asanuma
Publikováno v:
Modern rheumatology. 30(6)
Background: Pentraxin 3 (PTX3) has an important role in inflammation, immunity, and atherosclerosis. Rheumatoid arthritis (RA) is a chronic inflammatory disease featuring both joint damage and athe...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::391aa009e1bfcec1e407e9e787d37779
https://pubmed.ncbi.nlm.nih.gov/31615315
https://pubmed.ncbi.nlm.nih.gov/31615315
Autor:
Satoko Ueno, Koji Arai, Tomoko Hasunuma, Yoshiro Saito, Akira Nakayama, Shin-Ichiro Nitta, Kosuke Saito
Publikováno v:
Journal of pharmaceutical sciences. 108(11)
Amino acids and lipids are biomarkers used to assess the presence and severity of disease, as well as the toxicological response to drugs. Although upper-extremity venipuncture is a well-used standard technique, fingertip capillary sampling is a more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b800e8f6f95f7bf6068934bd651bcfe
https://pubmed.ncbi.nlm.nih.gov/31493412
https://pubmed.ncbi.nlm.nih.gov/31493412
Autor:
Tomoko Hasunuma, Hirokazu Wakuda, Osamu Ogawa, Tetsuji Ohyama, Naoyuki Otani, Yasuyuki Ishii, Masae Kuranari, Naoto Uemura, Yuko Ito, Akihiro Okubo, Kenji Takeda, Hiromitsu Imai
Publikováno v:
Clinical and Translational Science
Clinical and Translational Science, Vol 12, Iss 5, Pp 513-518 (2019)
Clinical and Translational Science, Vol 12, Iss 5, Pp 513-518 (2019)
This study evaluated the utility of combination of digoxin (0.25 mg) and rosuvastatin (5 mg) as a new transporter (P‐glycoprotein/breast cancer resistance protein/organic anion‐transporting polypeptide (OATP)1B1/OATP1B3) probe cocktail (Oita comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2545bb3885039bd5a44af3ad0dd955d3
https://pubmed.ncbi.nlm.nih.gov/31095880
https://pubmed.ncbi.nlm.nih.gov/31095880