Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Tomoki Takeuchi"'
Autor:
Fumihito Ushiyama, Hideaki Amada, Tomoki Takeuchi, Nozomi Tanaka-Yamamoto, Harumi Kanazawa, Koichiro Nakano, Masashi Mima, Aiko Masuko, Iichiro Takata, Kosuke Hitaka, Kunihiko Iwamoto, Hiroyuki Sugiyama, Norikazu Ohtake
Publikováno v:
ACS Omega, Vol 5, Iss 17, Pp 10145-10159 (2020)
Externí odkaz:
https://doaj.org/article/17fa358e19ce435eaf8d3e740e6f6ab1
Autor:
Tomoki Takeuchi, Yusaku Nomura, Tomoko Tamita, Rie Nishikawa, Hiroyuki Kakinuma, Naoki Kojima, Kosuke Hitaka, Yunoshin Tamura, Masafumi Kamitani, Masashi Mima, Akiko Nozoe, Masato Hayashi
Publikováno v:
Journal of Medicinal Chemistry. 66:822-836
Matrix metalloproteinase-2 (MMP2) is a zinc-dependent endopeptidase and a promising target for various diseases, including cancer and fibrosis. Herein, we report the discovery of a novel MMP2-selective inhibitor with high chemical stability and slow
Autor:
Tomoki Takeuchi, Masato Hayashi, Tomoko Tamita, Yusaku Nomura, Naoki Kojima, Akiko Mitani, Takuya Takeda, Kosuke Hitaka, Yuki Kato, Masafumi Kamitani, Masashi Mima, Hidetoh Toki, Masahiko Ohkubo, Akiko Nozoe, Hiroyuki Kakinuma
Publikováno v:
Journal of Medicinal Chemistry. 65:8493-8510
Matrix metalloproteinase-2 (MMP2) is a zinc-dependent endopeptidase that plays important roles in the degradation of extracellular matrix proteins. MMP2 is considered to be an attractive target for the treatment of various diseases such as cancer, ar
Autor:
Hirohito Kato, Akio Tanaka, Kazuya Masuno, Nobutaka Okusa, Yoichiro Taguchi, Makoto Umeda, Tomoki Takeuchi, Kazuya Tominaga
Publikováno v:
Journal of Hard Tissue Biology. 28:251-258
Publikováno v:
Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology). 59:39-47
Autor:
Masato Kaneda, Nobutaka Fujii, Kosuke Namba, Ayumi Osawa, Akira Asai, Tomoki Takeuchi, Keiji Tanino, Shinya Oishi, Jun-ichi Sawada
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26(23):5765-5769
1,3a,6a-Triazapentalene is a compact fluorescent chromophore. In this study, triazapentalene was used to modify a series of biphenyl-type inhibitors of kinesin spindle protein (KSP) to develop fluorescent probes for the intracellular visualization of
Publikováno v:
Archives of oral biology. 112
Objective The aim of the present study was to investigate the effect of palmitate on human periodontal ligament stem cells (PDLSCs). Design PDLSCs were isolated from the third molars of healthy adult donors, and cultured in normal or osteogenic mediu
Autor:
Masato Kaneda, Nobutaka Fujii, Hiroaki Ohno, Isao Nakanishi, Akira Asai, Ryosuke Misu, Shinya Nakamura, Tomoki Takeuchi, Shinya Oishi, Jun-ichi Sawada
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:3171-3179
Structure–activity relationship studies of diaryl amine-type KSP inhibitors were carried out. Diaryl amine derivatives with a pyridine ring or urea group were less active when compared with the parent carboline and carbazole derivatives. Optimizati
Autor:
Kazuo Kitaura, Akira Asai, Tomoki Takeuchi, Naoya Asada, Hiroaki Ohno, Shinya Oishi, Jun-ichi Sawada, Toshiaki Watanabe, Kenji Matsuno, Nobutaka Fujii
Publikováno v:
Journal of Medicinal Chemistry. 54:4839-4846
The kinesin spindle protein (KSP) is a mitotic kinesin involved in the establishment of a functional bipolar mitotic spindle during cell division. It is considered to be an attractive target for cancer chemotherapy with reduced side effects. Based on
Autor:
Mitsuko Takenaga, Nobutaka Fujii, Tomoki Takeuchi, Akemi Hamaguchi, Yuki Ohta, Yukie Tokura, Hideki Nakashima, Shinya Oishi, Daisuke Asai, Yuki Yamamoto
Publikováno v:
Biochemical and biophysical research communications. 463(3)
Among synthetic kinesin spindle protein (KSP) inhibitor compounds, KPYB10602, a six-member lactam-fused carbazole derivative was the most potent in vitro against cell growth of human ovarian cancer, A2780. KPYB10602 caused dose-dependent suppression