Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Tomoki Isayama"'
Autor:
Alexandre Pertzev, Michael A. Sandberg, Rameshwar K. Sharma, Polina Geva, Tomoki Isayama, Clint L. Makino, Teresa Duda
Publikováno v:
eNeuro
The membrane guanylate cyclase, ROS-GC, that synthesizes cyclic GMP for use as a second messenger for visual transduction in retinal rods and cones, is stimulated by bicarbonate. Bicarbonate acts directly on ROS-GC1, because it enhanced the enzymatic
Autor:
Michael Slavsky, Tomoki Isayama, Eduard Fabre, Masahiro Kono, Rosalie K. Crouch, Clint L. Makino, Ying Chen, Willem J. DeGrip, Jian Xing Ma
Publikováno v:
Journal of Comparative Neurology. 522:2249-2265
Although more than one type of visual opsin is present in the retina of most vertebrates, it was thought that each type of photoreceptor expresses only one opsin. However, evidence has accumulated that some photoreceptors contain more than one opsin,
Publikováno v:
Visual Neuroscience. 28:485-497
The visual pigment, rhodopsin, consists of opsin protein with 11-cisretinal chromophore, covalently bound. Light activates rhodopsin by isomerizing the chromophore to the all-transconformation. The activated rhodopsin sets in motion a biochemical cas
Autor:
Irma Ugalde, David M. Berson, Tomoki Isayama, Brendan J. O'Brien, Jay F. Muller, Vikas Aurora, Aaron Frenz, William G. Tsiaras
Publikováno v:
The Journal of Comparative Neurology. 517:459-480
The ferret is the premiere mammalian model of retinal and visual system development, but the spectrum and properties of its retinal ganglion cells are less well understood than in another member of the Carnivora, the domestic cat. Here, we have exten
Publikováno v:
Visual Neuroscience. 26:267-274
Vision begins with photoisomerization of 11-cis retinal to the all-trans conformation within the chromophore-binding pocket of opsin, leading to activation of a biochemical cascade. Release of all-trans retinal from the binding pocket curtails but do
By generating the second messenger cGMP in retinal rods and cones, ROS-GC plays a central role in visual transduction. Guanylate cyclase-activating proteins (GCAPs) link cGMP synthesis to the light-induced fall in [Ca(2+)]i to help set absolute sensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd63b4e299fe2040086cae300199015
https://europepmc.org/articles/PMC4409265/
https://europepmc.org/articles/PMC4409265/
Publikováno v:
Visual Neuroscience. 13:695-704
Endogenous opioid systems (i.e. opioid peptides and opioid receptors) modulate developmental events in the neonatal mammalian retina. In the present study, the mRNA encoding preproenkephalin A (PPE), the prohormone for the opioid growth factor (OGF),
Publikováno v:
Molecular Brain Research. 21:85-98
[Met5]-Enkephalin is derived from the protein precursor, proenkephalin A, which in turn is encoded by the preproenkephalin (PPE) gene. [Met5]-Enkephalin is not only a putative neuromodulatory substance, but also serves as a growth factor (= opioid gr
Autor:
Anita L. Zimmerman, Masahiro Kono, Clint L. Makino, Tetsuji Okada, Sadaharu Miyazono, Tomoki Isayama, Rosalie Crouch
Publikováno v:
The FASEB Journal. 24
Publikováno v:
The Journal of Neuroscience. 11:3531-3538
Spectrin is a major component of the mammalian neuronal cytoskeleton. In the CNS, three isoforms of brain spectrin are known to exist: a cellular and dendritic isoform, (240/235E), related to neurons and glia; a cellular and axonal isoform, (240/235)